, Charlebois, I.
, Kell, A.J.
, Leclerc, M.
, Simard, B.
, Tan, S.
, National Research Council, CA
We have developed a nanoparticle-based DNA biosensor that can detect unlabelled ssDNA with good sensitivity (picomolar concentrations). The biosensor makes use of the optical changes of a cationic polymer interacting with ssDNA versus that of [...]
Rapid, sensitive and inexpensive analysis of biological molecules is of great importance to many biomedical applications, such as disease detection and monitoring, drug discovery, detection of pathogens, etc. Mechanical resonators have been demonstrated as highly [...]
Much attention has been focused on using magnetic particles for biodetection applications on chip. Most of these applications involve using the magnetic particles either for translational motion in a magnetic field, or as labels for [...]
In this report, we introduce evolved AMPs as a new class of capture agents for nanowire/nanotube biosensors, and demonstrate selective detection of a protein related to severe acute respiratory syndrome (SARS), using devices based on [...]
In this contibution I will present some of our work on solid-state nanopores, the fabrication of nanopore/electrode structures and how these can be used for single-molecule biosensing applications (DNA, proteins etc.). Specifically, I will introduce [...]
Significant enhancements in the SERS signals may be obtained with elongated arrangement of silver or gold nanoparticles. Silica nanosprings (NS) with high surface to volume ratio are promising candidate to yield such sensor materials. In [...]
, Grieten, L.
, Haenen, K.
, Michiels, L.
, Vanden Bon, N.
, Vermeeren, V.
, Wagner, P.
, Wenmackers, S.
, Hasselt University, BE
Healthcare and diagnostics are moving towards molecular medicine. Hence, a lot of research is being performed on biosensors. However, rarely one has reached the commercialization phase because of the expensive infrastructure required for signal read-out. [...]
, Jejelowo, O.A.
, Mak, A.C.
, Osterfeld, S.
, Pourmand, N.
, Wang, S.
, Yu, H.
, Stanford University, US
Rapid, sensitive and multiplexed measurement is vital in molecular diagnostics such as cancer diagnosis and pathogens detection. While highly specific and sensitive, traditional immunochemical assays such as enzyme-linked immunosorbent assays (ELISAs) often require expensive read-out [...]
, Ahn, C-G
, Kim, A.
, Kim, T.
, Park, C.W.
, Sung, G.Y.
, Yang, J.H.
, Electronics and Telecommunications Research Institute, KR
This paper presents photosensitive biosensor array chips with the simple photodiode array having the optical input signal and the electrical output signal, which detects the photocurrent change caused by a reaction between probe molecules and [...]
, Costea, D.E.
, Fedele, S.
, Hughes, M.P.
, Johannessen, A.C.
, Labeed, F.H.
, Lewis, M.P.
, Liang, X.
, Mulhall, H.J.
, Porter, S.
, Tsinkalovsky, O.
, University of Surrey, UK
Microengineered medical devices offer many potential benefits for point-of-care healthcare and rapid diagnosis. We have developed a microengineered system using the electrostatic phenomenon dielectrophoresis (DEP) to non-invasively determine the electrophysiological parameters of normal and cancerous [...]
The immobilization of biomolecules on solid support is crucial component in fabrication of biosensors. The self assembled monolayers (SAM) can be used for fabrication of the biosensor-component that allows chemically reactive functional group manipulations for [...]
We report a new method to separate cells in microfluidic devices by directing the trajectories of cells along asymmetric receptor edges. This approach relies on cell rolling, a physiological phenomenon involving transient interactions of the [...]
This paper introduces a new DNA extraction and purification method from whole blood. Mixing and separation steps are performed using functionalised superparamagnetic beads suspended in cell lysis buffer in a circular chamber that is sandwiched [...]
We report the development of a microfabricated electrophoretic device for assembling high-density arrays of antibody-conjugated microbeads for chip-based protein detection. The device consists of a flow cell formed between a gold-coated silicon chip with an [...]
, Klapperich, C.M.
, Mirer, P.L.
, Sauer-Budge, A.F.
, Sharon, A.
, Fraunhofer USA, US
In this paper we describe a completely integrated lab- on-a-chip for genetic analysis of bacteria or viruses. The chip was designed for low cost manufacturing in thermoplastics by choice of low cost materials (thermoplastics) and [...]
We investigate the plasmonic responses of gold nanoparticles (AuNP) coated and uncoated on 30nm gold thin film with aqueous medium having different refractive index using SPR ellipsometry. (See Figure 1) The sensitivities in both cases [...]
, Dias, J.T.
, Doria, G.
, Franco, R.
, Larguinho, M.
, Pereira, E.
, CIGMH/DCV & REQUIMTE/DQ, PT
Due to their unique optical properties, noble metal nanoparticles, and in particular gold nanoparticles (AuNPs), have been extensively used for the development of new molecular diagnostic assays. These optical properties derive from the characteristic surface [...]
In this presentation we introduce a novel optofuidic biochemical sensor in which detection is based on the contrast between the refractive index of a target biomaterial and the ambient carrier fluid. The sensor consists of [...]
Nanoparticle based hybrid imaging by MRI, PET-CT and Fluorescent reflectance techniques are emerging in imaging carotid artery disease. 64Cu-TNP is detectable by MRI and PET-CT. A trimodality reporter 64Cu-TNP is a derivatization product made of: [...]
Au from Au–Ag core–shell nanoparticles acts as multimodal Gold-speckled silica nanoparticles as contrast agents for noninvasive imaging with magnetic resonance imaging and photoacoustic tomography. These Au nanopeanuts can be prepared in a simple one-pot synthesis [...]
There has been recent interest in the use of gold nanoparticles as contrast media in cancer diagnosis. This utilises either a high-concentration suspension to highlight all areas of vasculature or as an antibody-conjugated species with [...]
, Fiori, F.
, Giuliani, A.
, Manescu, A.
, Torrente, Y.
, Villa, C.
, Polytechnic University of Marche, IT
This work was carried out in the frame of a more general research program aiming to use human stem cells to repair muscle damage in Duchenne Muscular Dystrophy. The results of X-ray microtomography experiments, carried [...]
, Edel, J.B.
, Instuli, E.
, Ivanov, A.
, Khongkow, M.
, Imperial College London, UK
In this work, we present first results from the experimental implementation of an electrode/nanopore architecture with the aim of characterizing ion and DNA transport under the influence of a local alternating electric field. This includes [...]
Nanopipette technology is capable of detecting and functional analyzing bio-molecules based on difference on their size, shape and electrical charge. This unique label-free biosensor is inexpensive, easy to fabricate and versatile. Nanopipette functionalized with antibodies [...]
, Huh, C.
, Kim, B-K.
, Kim, K.H.
, Ko, H.S.
, Sung, G.Y.
, ETRI, KR
We have studied for lab-on-a-chip (LOC) based bio-devices and fabricated plastic optical label-free biosensor device. Optical resonant reflection biosensor (ORRB) is a kind of label-free sensor, containing nanoscale resonate grating patterns1 and whole blood filter. [...]
, Cantrell, T.
, Corti, G.
, McIlroy, D.N.
, Norton, M.G.
, Prakash, T.
, GoNano Technologies, Inc., US
GoNano Technologies NanospringTM material is proposed as an enhancement of enzyme-linked immunosorbent assay (ELISA) to increase detection sensitivity. The high surface area and hydroxyl rich surface chemistry provides greater attachment capability and decreased functional surface [...]
, Kim, N.
, Kim, S-H
, Koh, K.
, Lee, M.
, Shin, C.-J.
, Ajou University, KR
The phosphate residue plays an important role as not only the structural component of DNA and lipid but also the activation signal of protein in the cellular signaling pathways. Therefore, the selective recognition for the [...]
The evolution of DNA biosensors should match commercial emergency of Nanotechnology in this genomic era. The ubiquitous oligonucleotide microarray ‘lab–on-chip’ is limited by high cost and man-power. However, emerging portable non-label DNA biosensors are yet [...]
Presented application is based on the use of carbon nanotubes (CNTs) for biomolecular analysis using electrochemiluminescence (ECL) detection technique. For this purpose we have grown self standing cylinder-shaped blocks of Multi wall CNTs (MWCNTs) by [...]
In this report the principle new instrumental method of the biochemical diagnostics of the bovine leucosis, autoimmune process at the diabetes and the control mycotoxins through the registration of the formation of the specific immune [...]
The mitochondrial membrane potential is used to generate and regulate energy in living systems, driving the conversion of ADP to ATP, and controlling apoptosis, all central to human health and disease. Therefore, there is a [...]
In our previous reports, we studied the development of biosensor platform that are capable of measuring biometabolites and environmental sensitive species, such as peroxide and nitrate/nitrate, to concentration in the order of ppb (parts per [...]
, Benyettou, F.
, Bonnin, D.
, Brioude, A.
, de Beaucorps, C.
, Lalatonne, Y.
, Motte, L.
, Weinmann, P.
, Avicenne Hôspital, FR
Magnetic nanoparticles (MNPs) are commonly used for contrast enhancement in magnetic resonance imaging, as magnetic carriers in automated immunoassays instruments, or for cell concentration at the bench. They are being evaluated all over the world [...]
Because of the health risks of aflatoxin B1 (ATB1), it is essential to monitor the level of this mycotoxin in a variety of foods. HPLC and ELISA methods require skilled personnel, expensive equipments, and complex [...]
, Danielsson, B.
, Deshpande, K.
, Mishra, R.K.
, Pal, S.
, Willander, M.
, Birla Institute of Technology & Science, Pilani-Goa Campus, IN
A novel biochip based detection for determination of ultra trace mercury (Ii), lead(II) and cadmium (II)in drinking water. High through put analysis, low sample volume, high sensitivity and rapid analysis is the hallmark of the [...]
In this report the experimental data about the determination of P toxicity by optical biosensors based on the application of chemiluminescence (ChL) of Daphnia magna living media (ChL-test) and bioluminescence (BL) of Ukrainian strains of [...]
In this paper, we present a simple method to fabricate an enzyme microreactor using soft lithography and magnetic microbeads. For proof of concept, we performed an enzymatic reaction by flowing non-fluorescent resazurin through diaphorase (DI) [...]
, Goel, S.
, Gong, M.
, Khuntontong, P.
, Kua, C.H.
, Wang, Z.P.
, Singapore Institute of Manufacturing Technology, SG
We present a polymer-based microfluidic device capable of performing various DNA preparation processes like enzymatic, end repairing, and purification. The system consisted of a disposable polymeric chip and a controlling unit. Mixing chambers, incubation chambers [...]
In human body, nanorobot-like red blood cells get exposed to human body fluids and many physico-chemical changes inside while these nanorobots (fullerene structure coated hemoglobin embedded iron inorganic elements) remain safe and perform killer action [...]
, Faulds, K.
, Geboers, M.
, Graham, D.
, Senior, L.
, Stevenson, R.
, University of Strathclyde, UK
We report the first use of ‘bare’ nanoparticles as both a cellular delivery vehicle and a spectroscopic detection platform to enable surface enhanced resonance Raman scattering (SERRS) detection. We have shown how this approach can [...]
A new fluorescent agent, FITC labeling agarose is designed to determine whether it can act as an effective fluorescent labeling agent of cell or not. The degraded agarose reacted with 3-chloro-1, 2-epoxypropane in NaOH medium [...]
We present a mathematical model and the computer simulation of Brownian motion of nanoparticle-bioprobe-polymer contrast agent complexes and their hybridization to immobilized targets. Our model is a stochastic counterpart of the continuous model presented in [...]
, Bulteel, O.
, Flandre, D.
, Gerard, P.
, Moreno-Hagelsieb, L.
, Raskin, J-P
, Université catholique de Louvain / SENSOI, BE
Low-power and high-temperature sensors and MEMS designs based on bulk, SOI and IC compatible materials and processes. Target markets are in general public sensors for UV, ozone, CO, liquids presence, e.g. in mobile devices. In [...]
Journal: TechConnect Briefs
Volume: 3, Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy
Published: June 21, 2010
Industry sectors: Medical & Biotech | Sensors, MEMS, Electronics
Topicss: Chemical, Physical & Bio-Sensors, Diagnostics & Bioimaging