Enhancement of anticancer action of traditional (doxorubicin and cisplatin) and experimental (landomycin A) drugs by their delivery in vivo with novel C60-fullerene-based nanocarriers possessing innate ROS-modulating activity

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Rapid development of multi-drug resistance of tumor cells to chemotherapy caused by the over-expression of specific ABC-transporter proteins and/or multiple defects in genes involved in cell cycle and apoptosis regulation in cancer cells frequently leads [...]

Conjugation of anticancer drugs with novel PEG-containing nanocarrier provides circumvention of drug-resistance mechanisms in vitro and protects of general toxicity in vivo

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In the last decade, the development of targeted drug delivery with conjugated nanoparticles brings more drug molecules to the diseased sites, at the same time reducing a systemic drug exposure. Polyethylene glycol (PEG) conjugation is [...]

Neuroactive Carbon Dots: Perspective Neurotheranostic Agents and Harmful Environmental Pollutant

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1 Palladin Institute of Biochemistry, NAS of Ukraine – RECOOP CRRC 2 International Research and Innovation in Medicine Program, Cedars-Sinai Medical Center, LA, CA, USA Carbon dots (C-dots) are a newly discovered class of fluorescent [...]

Hydrophilic NaYF4 nanocrystals doped with Eu3+: Effects of surface functionalization on glutamate and GABA transport in brain nerve terminals

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Hydrophilic NaYF4 nanocrystals doped with Eu3+: Effects of surface functionalization on glutamate and GABA transport in brain nerve terminals T. Borisova2, B.Sojka1, D.Kociołek1, M. Banski1, N. Pozdnyakova2, A. Pastukhov2, A.Borysov2, M. Galkin2, M. Dudarenko2, A. [...]

Why not only electrostatic discharge but even a minimum charge on the surface of highly sensitive explosives can catalyze their gradual exothermic decomposition and how a cloud of unipolar charged explosive particles turns into ball lightning

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Even a single excess electron or ion migrating on the surface of sensitive explosives can catalyze their gradual exothermic decomposition. Mechanisms underlying such a charge-induced gradual thermal decomposition of highly sensitive explosives can be different. [...]