Nanopore/electrode structures for single molecule biosensing


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In this contibution I will present some of our work on solid-state nanopores, the fabrication of nanopore/electrode structures and how these can be used for single-molecule biosensing applications (DNA, proteins etc.). Specifically, I will introduce a new way of fabricating small metal nanopores with diameters below 20 nm and well-defined pore conductance, based on electrodeposition and ion-current feedback control. This fabrication method is relatively inexpensive and can easily be multiplexed. Moreover, the surface properties of these metal nanopores can either be switched electrically (by applying a potential) or chemically by molecular self-assembly. Proof-of-concept single-DNA translocation experiments have been performed to show the applicability of the technique to fabricating single-biomolecule sensing devices. Finally, I will present some of our other work in this area on multi-electrode/nanopore devices.

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Journal: TechConnect Briefs
Volume: 3, Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy
Published: June 21, 2010
Pages: 15 - 18
Industry sectors: Medical & Biotech | Sensors, MEMS, Electronics
Topics: Chemical, Physical & Bio-Sensors, Diagnostics & Bioimaging
ISBN: 978-1-4398-3415-2