Label-free, Fluorescenece Detection of DNA Nanoparticle Scaffolds
Boissinot M., Charlebois I., Kell A.J., Leclerc M., Simard B., Tan S., National Research Council, CA
We have developed a nanoparticle-based DNA biosensor that can detect unlabelled ssDNA with good sensitivity (picomolar concentrations). The biosensor makes use of the optical changes of a cationic polymer interacting with ssDNA versus that of [...]