Functionalized Nanopipette: towards single cell immunoassay

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Nanopipette technology is capable of detecting and functional analyzing bio-molecules based on difference on their size, shape and electrical charge. This unique label-free biosensor is inexpensive, easy to fabricate and versatile. Nanopipette functionalized with antibodies specific to HT-2 toxin, a food-borne pathogen, showed a limit of detection for HT-2 toxin as low as 100 fg/ml with a dynamic range of 4 logs. We are currently investigating the application of functionalized nanopipette for HPV proteins detection. A highly sensitive nanopipette probe can be precisely positioned at any sub-cellular region, thus paving the way for single cell immunoassay.

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Journal: TechConnect Briefs
Volume: 3, Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy
Published: June 21, 2010
Pages: 88 - 90
Industry sectors: Medical & Biotech | Sensors, MEMS, Electronics
Topicss: Chemical, Physical & Bio-Sensors, Diagnostics & Bioimaging
ISBN: 978-1-4398-3415-2