Diagnostics & Bioimaging – TechConnect Briefs

An ultrasensitive and culture-free detection platform for microorganisms and protein biomarkers

Yau S.-T., Rapidect, Inc., US

We have developed an electrochemical immunoassay platform, which detects a range of disease-related targets including bacteria, viruses, fungi and protein biomarkers. The platform features a voltage-controlled signal amplification, which leads to ultrasensitive detection. The analytical [...]

Catalytic Nanoparticles to Enhance the Sensitivity of Lateral Flow Immunoassays

Kidwell D.A., Lanese J.N., Mulvaney S., Wei E., Naval Research Laboratory, US

Lateral-flow immunoassays (LFIAs) are a widely used point- of-care technology. They are most familiar as home-pregnancy tests, but are also employed for testing for a wide variety of diseases, biomarkers, and even small molecules. By [...]

Nanobiomimetic Structured Organo-Metal Devices Direct Rapid Real-time Monitor Atto Molarities of ATP in Biological Specimens

Chen E.T., Duh S-H, Kissinger P.T., Thornton J.T., Advanced Biomimetic Sensors, Inc., US

Real-time monitoring of ATP in biological specimens is a convenient means to monitor the hygiene in healthcare units and for medical devices. Rapid and precise monitoring of ATP has been in strong demand. We report [...]

An electrostimulation cell device with patterned TiO2: Nb thin films as bio-electrodes

Benvenutti G., Jobin M., Pellodi C., Sandoz A., Sandu C., Stoppini L., hepia / HES-SO University of Applied Sciences of Western Switzerland, CH

We present a cellular test device based on Nb:TiO2 (niobium dooped titania) transparent conductive oxide (TCO) as bio-electrodes. The device is intended to easily provide electrical stimuli to a given cell tissue and to monitor [...]

Air Powered Artifical Lungs and other High Efficiency Fluid Reactor Innovations

Gainey S., Kumar A., Strobl K., CVD Equipment Corporation, US

Commercially available Hollow Fiber (HF) based Extracorporeal Membrane Oxygenators (ECMO) are presently being built using a parallel assembly of over 10- 20K of porous hollow polymeric fibers as respective reactor core elements (RCE). They are [...]

A Biomedical Sensor Based on Resonant Absorption of Ultrasound Waves in Hydrogel-based Resonators

Farhoudi N., Leu H-Y, Magda J., Reiche C.F., Solzbacher F., University of Utah, US

Smart hydrogels can be tailored to undergo a vol- ume change in response to an analyte. The potential biocompatibility of these materials has made them a very promising material for biomedical sensing applica- tions. To [...]

M2D2: a successful model catalyzing medical device innovation and development

Hafer N., McCarthy S., McManus D., Picard M., Tello, S., University of Massachusetts Center for Clinical and Translational Science, US

The Massachusetts Medical Device Development (M2D2) center offers inventors and small medical device companies coordinated access to research, engineering, and clinical investigation at the UMass Medical School (UMMS) and UMass Lowell (UML) campuses. UMMS provides [...]

Personalized nanomedicine for the treatment of vascular hypertension in polycystic kidney disease models

Nauli S.M., Pala R., University of California Irvine, US

In our current study, we designed a nanomedical device for the treatment of vascular hypertension in polycystic kidney disease (PKD) model through cilia targeting. We generated and compared two different metal and polymer cilia-targeted nanoparticle [...]

Enhancement of Effects of Chitosan and Nanoparticles on Pancreatic Cancer Cells by Combination Treatments with the Anti-Cancer Drug Adriamycin

Bhushan A., Gao W., Lai J.C.K., Leung S., Idaho State University College of Pharmacy, US

Because of chitosan’s roles in biomedical applications, this study investigated the effects of chitosan, chitosan in combination with silver or gold nanoparticles, and chitosan with nanoparticles and Adriamycin, Methotrexate or Cisplatin on human PANC-1 pancreatic [...]

Cytotoxic Effects of Short Multi-Wall Carbon Nanotubes on Pancreatic Cancer Cells

Bhushan A., Desai V., Lai J.C.K., Leung S., Zhang Y., Idaho State University College of Pharmacy, US

Although carbon nanotubes (CNTs) are increasingly exploited in diverse industrial and biomedical applications, their health hazard to humans is poorly understood. We have developed many cell models in vitro to systematically study the putative cytotoxicity [...]