Diagnostics & Bioimaging

Customized Nanoparticle Probes for Biomedical Imaging, Diagnostics and Therapeutics Applications

Nallathamby, P., University of Notre Dame, US

The modular synthetic approach that was developed to design a spectral library of core-shell nanoparticle contrast agents, which will have broad applications in biomedical imaging due to the potential for multi-modal imaging (e.g., fluorescence, MRI, [...]

RECAL: A New Ultrastable Luminescent Probe for Bioimaging

Borders, B.C., Brozik, J.A., Kang, C.H., Photon Biosciences, LLC, US

Luminescent probes, such as fluorescent proteins, fluorescent dyes, phosphorescent dyes, and quantum dots, are important tools in biology, biophysics, and medical diagnostics. While these tools are incredibly useful and are suitable for use in many [...]

Functionalized Carbon Nanotube-based Microelectronic Sensor Array for Early Diagnosis of Alzheimer’s Disease

Alam, M.M., Johnston, A.S., Tang, Y., InnoSense LLC, US

We designed and developed a lab-on-a-chip for the early diagnosis of Alzheimer’s Disease (AD) based on our patent-pending innovative nanotechnology by utilizing patterned microelectronic sensor devices for detecting Food and Drug Administration (FDA)-approved AD biomarkers [...]

Quantitative Electrolateral Flow Immunosensor (ELLI): Dengue Triage and Stroke Prognosis Case Studies

Fajs, L., Marks, R.S., Sinawang, P.D., Ben-Gurion University of the Negev, IL

The development of a rapid, affordable, and sensitive diagnostic kit for point-of-care is important in most healthcare settings; however, only a few exhibit the needed quantitative capability. Our technology, ELLI, is a patented diagnostic device [...]

Nanobiomimetic Superlattice Superconductive/Memristive Organometallic Devices at Room Temperature Serve as Chronoamperometric Sensors for sub fg/mL Collagen-1 Detection in Human Serum

Chen, E.T., Duh, S-H, Kissinger, P.T., Thornton, J.T., Advanced Biomimetic Sensors, Inc., US

Superconductive/Memristive devices have potential applications in supercomputing and in health industry was proposed in literature. Clinically detection range at low concentration for collagen-1 is difficult to accomplish due to the denaturing of protein Matrix Matelloprotinase-2 [...]

Multiplex Express In Vitro Diagnostics based on Magnetic Nanoparticles

Bragina, V.A., Gorshkov, B.G., Guteneva, N.V., Nikitin, M.P., Nikitin, P.I., Orlov, A.V., Znoyko, S.L., General Physics Institute, Russian Academy of Sciences, RU

Magnetic nanoparticles (MP) have provided many breakthrough solutions for life science. The immense potential of MP as labels in advanced immunoassays stems from the fact that they, unlike optical labels, can be easily detected inside [...]

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Novel fluorescent nanoparticles for ultrasensitive identification of nucleic acids by optical methods

Astakhova, K., Kjems, J., Okholm, A., Taskova, M., Westergaard Mulberg, M., University of Southern Denmark, DK

There have been an enormous interest in new amplification-free detection methods. A tremendous progress has been made in fluorescence based optical detection of biomolecules, which here resulted in the synthesis of novel ultra bright fluorescent [...]

Carcinoma cellular uptake, imaging, and targeting by RGDS- and TAT-conjugated upconversion and/or magnetic nanoparticles

Horák, D., Jirák, D., Kostiv, U., Proks, V., Institute of Macromolecular Chemistry AS CR, CZ

Specific targeting and in vivo visualization of cancer cells is of crucial importance for early detection and treatment of cancer. We have developed monodisperse poly(ethylene glycol) (PEG)-modified SiO2-coated Fe3O4 superparamagnetic nanoparticles [1] with size tuned [...]

Point-of-Care (POC) Micro Biochip for Cancer Diagnostics

Lee, E-S, Nunna, B.B., New Jersey Institute of Technology, US

American cancer society stated that a total of 1,685,210 new cancer diagnosed cases out of which 595,690 deaths from cancer are expected to be reported in the United States of America in 2016. Unfortunately Cancer [...]