Synchrotron radiation microtomography for the ex-vivo and in-vivo evaluation of nanoparticle-labeled stem cell homing in muscular tissue

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This work was carried out in the frame of a more general research program aiming to use human stem cells to repair muscle damage in Duchenne Muscular Dystrophy. The results of X-ray microtomography experiments, carried out both ex-vivo and in-vivo at the European Synchrotron Radiation Facility are presented. It is shown that the distribution of intra-arterially delivered stem cells can be visualized by microtomography both in muscle biopsies and in living murine models, providing biological insights into the early processes of muscle stem cell homing.

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Journal: TechConnect Briefs
Volume: 3, Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy
Published: June 21, 2010
Pages: 81 - 84
Industry sectors: Medical & Biotech | Sensors, MEMS, Electronics
Topicss: Chemical, Physical & Bio-Sensors, Diagnostics & Bioimaging
ISBN: 978-1-4398-3415-2