Silver is one of the oldest known natural antimicrobial materials, the active form being the Ag+ ion, which disrupts critical cell functions in bacteria. Reducing the size of silver particles to the nano-scale regime increases [...]
Main points from a pharma perspective: Review nanotech’s current position Nanotech and its realistic potential Nanotech and the barriers into the clinic GSK’s position on the subject matter
The pharmaceutical industry is facing the problem of an increasing number of drug substances in development which are either poorly water soluble or show pH dependency of solubility. Drug targeting and tailored delivery poses additional [...]
Proteases are key enzymes that regulate both normal and malignant tumor progress. Evaluating these enzymes and their inhibitors, therefore, has a great potential to diagnostics or therapeutic treatment against specific diseases or disorders. We have [...]
2-Nitroimidazole is radiosensitizer and serves as imaging contrast agent by 19F- and 31P MR methods. Despite the success of mesonidazole and SR-4554 compounds, very little is known of its hepato-cytotoxicity if it can be potential [...]
Specific external control of biomolecular activity is a critical step in harnessing the power of nature’s molecular machinery. We propose and demonstrate one control method, a biomolecular activity switch. Since proteins are the primary macromolecule [...]
Infectious diseases and bioterrorism are of tremendous global concern, and our group is interested in developing superparamagnetic nanoparticle platforms that can aid in the magnetic extraction/concentration and detection of harmful pathogens. This has led to [...]
The objective of this study was to create a novel biomimetic hydrogel composite based on helical rosette nanotubes (HRNs) and nanocrystalline hydroxyapatite (HA). HRNs are newly-developed self-assembled nanomaterials with DNA base pair building blocks. HRNs [...]
Dense ordered collagen matrices can be obtained by fine tuning the electrostatic interactions in highly concentrated solutions of type I collagen. Such biomimetic fibrillar materials have a high application potential in the field of tissue [...]
Controlling the morphology and function of cells using substrate nanotopography is a phenomenon that can be utilized in a variety of fields including tissue engineering and regenerative medicine. In this work, we explored the possibility [...]
Synthetic polymers and bioinspired fibrous materials have a significant impact in medicine in the recent years. The design and fabrication of new bio-materials has a great influence in several scientific and medical communities. The potential [...]
Cerium oxide nanoparticles (nanoceria) are potent free radical scavengers with neuroprotective, radioprotective, and anti-inflammatory properties. However, most synthetic procedures for nanoceria results in nanoparticles with poor water solubility or synthesized by procedures involving toxic solvents, [...]
The development of nanomaterials for biomedical and biotechnological applications is an area of research that holds great promise and intense interest. Carbon nanotubes (CNT) are thought to lead to novel types of nanomedicines. In our [...]
The meeting of nano-materials with biology has produced a new generation of technologies that can profoundly impact biomedical research. The NIR emitting window (650-900 nm) is appealing for in vivo optical imaging because of the [...]
Utilizing state-of-the-art molecular dynamics simulation techniques, we have developed a methodology for determining the gross functionalization parameters required to promote formation of small, compact, and stable nanoparticle clusters in aqueous solutions. The ultimate goal of [...]
Protein glycosylation is one of the most essential processes in the living systems, and often is a major target for developing therapeutics and diagnosis. We have developed a chip-based energy transfer system between quantum dot [...]
Mesoporous silica nano-particles were immobilized with luciferase and antibodies for immune-bioluminescence detection of Staphylocuccus aureus enterotoxin B (SEB) and C (SEC). Mesoporous silica nano-particles were used as matrix to immobilize antibodies specific for enterotoxins and [...]
This work presents a novel technique to measure the temperature in the vicinity (~3.5 nm) of a remotely heated, ultra-small gold nanoparticle. The temperature measurement is carried out employing fluorescent thermometry and core/shell CdSe quantum [...]
Gold nanoparticles and colloids have been used for a long time in biomolecular imaging and detection. With further understanding on many of the electrical and optical properties of gold nanoparticles revealed recently, the application of [...]
We have developed a novel surface enhanced resonance Raman scattering (SERRS) detection method that is amenable for almost any biological target. By utilising the information rich spectrum obtained from SERRS we show that we can [...]
, Bonroy K.
, Borghs G.
, Huang C.
, Jans H.
, Jans K.
, Reekmans G.
, Stakenborg T.
, Trekker J.
, Van de Broek B.
, Van Meerbergen B.
, Van Summeren A.
, Verhaegen K.
, Willems M.
, IMEC, BE
Nanomaterials differ significantly from other materials due to two factors: increased surface area and quantumsize effects. These factors can enhance properties such as reactivity, strength and physical characteristics. Due to these characteristics, the coupling of [...]
The role of kinases in transformation and cancer progression is established. We hypothesize that The role the specific phosphoproteins/phosphopeptides will be present in cancer patient serum as leak proteins and their isolation and identification will [...]
The purpose of this paper is to develop nano-contact imprint technology with simple process by using soft HSQ (hydrogen silsesquioxane) mold transfer aminosilane ink on HSQ and glass substrates with binding Glutraic dialdehyde (GA) and [...]
A dormant bacterial spore is regarded as a natural ionic reservoir, i.e. a system capable of changing the external pH or ionic strength by accumulating or releasing ions. In this work, we introduce a method [...]
Biomolecular interactions, which are responsible for many physiologically important processes, can be studied by molecular recognition force microscopy (MRFM). In MRFM, nanoNewton scale single molecule interactions are observed and quantified one by one as an [...]
There has been a considerable growth and development in electrospun nanofibers for research activity, as well as commercial fabrication over the past couple of decades. These continuous nanofibers are solution driven exclusively by an electric [...]
Hyaluronan (HA) is a glycosaminoglycan with a number of biological roles, such as being a key structural component of extracellular matrix and an important mediator in the leukocyte adhesion and migration. HA is ubiquitous in [...]
, Blankenstein G.
, Duong T.
, Hausmann M.
, Kentsch J.
, Paulus A.
, Posch A.
, Stelzle M.
, Stoll D.
, NMI Natural and Medical Sciences Institute, DE
The availability of an easy-to-use, reproducible method for subcellular fractionation would significantly promote qualitative and quantitative analysis of subcellular protein composition. A microfluidic system with integrated electrodes was designed and fabricated allowing for dielectrophoretic manipulation [...]
We have examined changes in single-walled carbon nanotubes (SWNT) optical signals upon addition of recombinant [FeFe] hydrogenases from Clostridium acetobutylicum or Chlamydomonas reinhardtii. We found evidence that novel and stable charge-transfer complexes are formed only [...]
Immobilization of free enzymes/proteins on water-insoluble mesoporous silica (MS) supports is often applied to obtain efficient biocatalysts for various applications. Three methods were applied for enzyme bonding onto MS: (1) physical adsorption with subsequent crosslinking [...]
A new kind of water-soluble luminescent superparamagnetic nanocomposite particles has been synthesized using a modified Stöber method combined with an electrostatic assembly process. Fe3O4 nanoparticles with the size of 10 nm were uniformly coated with [...]
Electrospinning is a simple, non mechanical method used to produce non-woven fabrics of ultrafine fibers in the nanometer diameter range (nanofibers).This method is appropriated to obtain high-surface-area polymeric fibrous membranes and is a one-step process [...]
Nanofiber scaffolds are potential materials in three-dimensional cell-culture media. Among the most common and attractive polymer used for this application is polycaprolactone (PCL). PCL is non-toxic, biodegradable and biocompatible synthetic aliphatic polyester. It is completely [...]
Big advances are being achieved in the design of new implantable devices. The implant-induced inflammatory reaction remains a significant challenge in this field. Coated scaffolds capable of releasing bioactive agents for inhibiting totally or partially [...]
In this study, we evaluated the cellular behaviors of human bone marrow stromal cells (hBMSCs) on the surface of apatite pre-coated poly( -caprolactone)–organosiloxane nano-hybrid material (SiOPCL) and assessed the osteoconductivity of SiOPCL in the diaphyses [...]
We show that broken symmetry, at the nano level, of biomolecules is key to phage invasion of a host cell, and take-over of the cell’s RNA-DNA replication processes. We determined that perturbation of cellular water [...]
This study was performed to evaluate the effect of hydroxyapatite-coated nanofibrous polycaprolactone membrane on proliferation and differentiation of periodontal ligament cell which is necessary for periodontal regeneration. Hydroxyapatite-coated nanofibrous polycaprolactone membrane was fabricated through electrospinning [...]
The combination of natural proteins with polymer membranes allows the formation of a novel nanocompartment combining the mechanical, chemical, and biological stability of the amphiphilic block copolymer with the functional specificity of membrane proteins. Functional [...]
Journal: TechConnect Briefs
Volume: 2, Nanotechnology 2008: Life Sciences, Medicine & Bio Materials – Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, Volume 2
Published: June 1, 2008
Industry sectors: Advanced Materials & Manufacturing | Medical & Biotech
Topicss: Biomaterials, Materials Characterization & Imaging