Papers:
Effect of Medical Device Substrate Material on Nanoparticulate Silver Efficacy
Silver is one of the oldest known natural antimicrobial materials, the active form being the Ag+ ion, which disrupts critical cell functions in bacteria. Reducing the size of silver particles to the nano-scale regime increases [...]
Nanomaterial: A realistic business case for Pharma
Main points from a pharma perspective: Review nanotech’s current position Nanotech and its realistic potential Nanotech and the barriers into the clinic GSK’s position on the subject matter
Towards nanosized particles in pharmaceutical industry
The pharmaceutical industry is facing the problem of an increasing number of drug substances in development which are either poorly water soluble or show pH dependency of solubility. Drug targeting and tailored delivery poses additional [...]
Multiplexed Proteolytic Enzyme Assay Based on Energy Transfer between Quantum Dots and Gold Nanoparticles
Oh Y.H., Kim H-S, Kim Y.P., Kim H-S, Kim Y.P., Korea Abvanced Institute of science and Technology, KR
Proteases are key enzymes that regulate both normal and malignant tumor progress. Evaluating these enzymes and their inhibitors, therefore, has a great potential to diagnostics or therapeutic treatment against specific diseases or disorders. We have [...]
2-Nitroimidazole as Potential Nanoprobe in Hypoxia Imaging by MRI/PET
2-Nitroimidazole is radiosensitizer and serves as imaging contrast agent by 19F- and 31P MR methods. Despite the success of mesonidazole and SR-4554 compounds, very little is known of its hepato-cytotoxicity if it can be potential [...]
Biomolecular activity switch: an application of metallic nanoparticle plasmon resonance
Alper J., Wijaya A., Crespo M., DeFlores L., Tokmakoff A., Hamad-Schifferli K., Massachusetts Institute of Technology, US
Specific external control of biomolecular activity is a critical step in harnessing the power of nature’s molecular machinery. We propose and demonstrate one control method, a biomolecular activity switch. Since proteins are the primary macromolecule [...]
Multifunctional nanoparticle platforms for pathogen diagnostic applications
Infectious diseases and bioterrorism are of tremendous global concern, and our group is interested in developing superparamagnetic nanoparticle platforms that can aid in the magnetic extraction/concentration and detection of harmful pathogens. This has led to [...]
Investigating Helical Rosette Nanotubes and Nanocrystalline Hydroxyapatite as Novel Bone-like Biomaterials for Orthopedic Applications
The objective of this study was to create a novel biomimetic hydrogel composite based on helical rosette nanotubes (HRNs) and nanocrystalline hydroxyapatite (HA). HRNs are newly-developed self-assembled nanomaterials with DNA base pair building blocks. HRNs [...]
Exploring the behavior of concentrated collagen, approaches to tailor biomimetic materials
Gobeaux F., Mosser G., Anglo A., Panine P., Davidson P., Giraud-Guille M.-M., Belamie E., Ecole Pratique des Hautes Etudes, FR
Dense ordered collagen matrices can be obtained by fine tuning the electrostatic interactions in highly concentrated solutions of type I collagen. Such biomimetic fibrillar materials have a high application potential in the field of tissue [...]
Enhancement of in vitro Capillary Tube Formation by Substrate Nanotopography
Bettinger C.J., Zhang Z., Gerecht S., Borenstein J.T., Langer R., Massachusetts Institute of Technology, US
Controlling the morphology and function of cells using substrate nanotopography is a phenomenon that can be utilized in a variety of fields including tissue engineering and regenerative medicine. In this work, we explored the possibility [...]
Effect of functionalization on the self-assembling propensity of beta sheet forming peptides
Taraballi F., Campione M., Vescovi A.L., Sassella A., Hwang W., Paleari A., Gelain F., University of Milan-Bicocca, IT
Synthetic polymers and bioinspired fibrous materials have a significant impact in medicine in the recent years. The design and fabrication of new bio-materials has a great influence in several scientific and medical communities. The potential [...]
Synthesis of Dextran-Coated Nanoceria with pH-dependent Antioxidant Properties
Cerium oxide nanoparticles (nanoceria) are potent free radical scavengers with neuroprotective, radioprotective, and anti-inflammatory properties. However, most synthetic procedures for nanoceria results in nanoparticles with poor water solubility or synthesized by procedures involving toxic solvents, [...]
Mechanisms of Cellular Interaction, Binding and Internalization of Functionalized Carbon Nanotubes
The development of nanomaterials for biomedical and biotechnological applications is an area of research that holds great promise and intense interest. Carbon nanotubes (CNT) are thought to lead to novel types of nanomedicines. In our [...]
Effect of Ligand Nature on the Kinetics and the Redistribution of Quantum Dots in Mice
The meeting of nano-materials with biology has produced a new generation of technologies that can profoundly impact biomedical research. The NIR emitting window (650-900 nm) is appealing for in vivo optical imaging because of the [...]
Optimizing nanoparticle functionalization for quantum dot formation
Utilizing state-of-the-art molecular dynamics simulation techniques, we have developed a methodology for determining the gross functionalization parameters required to promote formation of small, compact, and stable nanoparticle clusters in aqueous solutions. The ultimate goal of [...]
Chip-Based Energy Transfer System between Quantum dots and Gold Nanoparticles for Analysis of Protein Glycosylation
Protein glycosylation is one of the most essential processes in the living systems, and often is a major target for developing therapeutics and diagnosis. We have developed a chip-based energy transfer system between quantum dot [...]
Functionalized Mesoporous Silica Nano-particle for Optical Bio-detection
Maki G., Maki W.C., Mishra N.N., Filanoski B., Rastogi S.K., Cameron E., Maki G., Maki W.C., University of Idaho, US
Mesoporous silica nano-particles were immobilized with luciferase and antibodies for immune-bioluminescence detection of Staphylocuccus aureus enterotoxin B (SEB) and C (SEC). Mesoporous silica nano-particles were used as matrix to immobilize antibodies specific for enterotoxins and [...]