Continuous advances in polymer chemistry are enabling the synthesis of novel responsive biomaterials. This class of biomaterials are polymers able to undergo significant changes in their properties in response to external stimuli. Depending on their [...]
We have studied long-range electron transfer through various lengths of helical peptides from 8 mer (24 Å) up to 80 mer (120 Å) in self-assembled monolayers prepared on a gold surface. Helical peptides carrying a [...]
We present an approach to fabricate capsules consisting of a composite layer of particles and block copolymers . The capsules are fabricated by the directed assembly of block copolymers at the interfaces of a double [...]
The binding between streptavin and biotin, which is one of the strongest non-covalent interactions known in nature, is used ubiquitously in molecular biology. However, when a biotinylated molecule is captured for testing purposes and cannot [...]
Materials were prepared similar to nacre with its layered structure of high filler content. Nacre is based upon about 95 %·w/w calcium carbonate as a composite with a layered block structure. Nacre has high modulus, [...]
Nanoviricides® anti-influenza agents are designed to mimic a natural host cell receptor to which all influenza A viruses bind and infect host cells. A nanoviricide is composed of a flexible polymer backbone with virus-specific ligands [...]
, Cingolani R.
, Galeone A.
, Maiorano G.
, Pompa P.P.
, Rizzello L.
, Sabella S.
, Sorce B.
, Vecchio G.
, Italian Institute of Technology, IT
We show the different response of human neuroblastoma cells line to gold surfaces with different levels of nanoroughness, finding out that neurons are capable to sense and actively respond to these nanotopography features, with a [...]
The in vitro cytotoxic response of human dermal and colon cell lines to structurally well-defined full generation cationic dendritic polyamidoamine (PAMAM) nanoparticles of generations G4, G5, G6 was investigated. PAMAM dendrimers have been demonstrated to [...]
Proliferation of osteoblast cells is enhanced on functionalized elastically deformed membrane
The bimodal combination of cellulose fibre dimensions resulted in complementary properties from the same chemical composition. The nano-cellulose fibers provided thixotropy to the castor oil based reactants. The composites exhibited strength, toughness and a modulus [...]
This study demonstrates the combined effect of the angiogenic proteins, hVEGF and hAng-1, coencapsulated in human serum albumin (HSA) nanoparticles (NPs), towards human umbilical vein endothelial cells (HUVECs) and an evaluation of the potential application [...]
The RAFT (Reverse Addition-Fragmentation chain Transfer) process is a ground breaking technology that offers unprecedented control over the composition, functionality and architecture of polymers. The versatility of the RAFT technology provides enormous potential for designing [...]
We demonstrate that the outermost proteinaceous surface layer SlaA of the thermo acidophilic archaeon Sulfolobus acidocaldarius is an excellent matrix for preparation of bio-Au nanoclusters. The archaeal bio-Au nanoparticles are significantly bigger and possess considerably [...]
The present paper describes NANOSKIN production for medical applications. Nanoskin is produced from the bionanotechnology process. Nanoskin is a highly hydrated pellicle made up of a random assembly of ribbon shaped fibers less than 100 [...]
LFIAs are used in the investigation of a variety of bio-molecular binding interactions and they remain the primary means for point of care and fast detection of analytes including pathogens and toxins. In a novel [...]
Lysozyme (LSZ) facilitates the dispersion of single-walled carbon nanotubes (SWNT) while maintaining its’ antibacterial activity through macroscopic processing. The structural and enzymatic nature of LSZ makes possible the dispersion of SWNT for processing into macroscopic [...]
We have developed a novel surface architecture for the generation of biocompatible and stable photoswitchable quantum dots (psQDs). The system is based on Förster Resonance Energy Transfer (FRET) from a QD donor to diheteroarylethenes photochromic [...]
In this study, hybrid silica-coated plasmonic-magnetic nanoparticles have been synthesized in one-step by a scalable flame aerosol technology. The effect of the silica in the stability of the nanoparticles, as well as their biocompatibility are [...]
In this work, nanostructures formed by the two whey proteins (alpha-lactoalbumin and beta-lactoglobulin) were synthesized througha thermal gelation process. The obtained proteic nanoparticles were characterized by using dynamic light scattering, transmission electron microscopy and atomic [...]
The design of an immunization regimen capable of inducing sustained genital mucosal Th1 response is the current goal for a vaccine for humans to control the severe complications of genital infection by C. trachomatis. In [...]
Amphiphilic block copolymers and mixtures of amphiphiles find broad applications in numerous nano-technologies. In our previous study, we showed that interactions between a biological charged diblock copolymer, beta-casein, and a synthetic uncharged triblock copolymer, Lutrol [...]
An annoying problem of chemotherapy was the drug resistance of cancer cell which was expression of multidrug-resistance associated proteins and resulted in ineffective treatment. To conquer this problem, a small interfering RNA (siRNA) molecule and [...]
In this study, we propose a novel yet simple method to generate titanium oxide 3-D nanofibrous structures on the titanium implants using femtosecond laser machining. The femtosecond laser pulses hit the titanium substrate and generate [...]
Composite substrates are considered as prospective matrix to populate and support cells in the bioengineering field. Synthetic degradable biomaterials, including poly(lactic acid) (PLA) and tricalcium phosphate (TCP), are widely used for matrix scaffold. In present [...]
In this paper, we present a novel cancer therapy method based on graphene inclusion in the cell solution and irradiation of the solution by near infrared lasers. The effect of various parameters such as graphene [...]
An important issue for all composites is reduction of creep. The reinforcing fibers dramatically reduce creep, however nano-composites can improve tensile properties and toughness. The aim of this work is to prepare and characterize PLA [...]
Currently, the vast majority of plastics are made from petroleum-based synthetic polymers that do not degrade in a natural environment and their disposal poses a serious problem. An environmentally-conscious alternative is to design polymer nanocomposites [...]
Nanoemulsions (NEs) and lipid nanoparticles (LNs) were regarded as suitable nanosized carriers of water-insoluble active components. These nanosized carriers could be used to load with drugs, nutrients and cosmetic actives and provide the appropriate application [...]
Our research interest is the combination of carbon nanotube electrochemistry with nanostructured substrates capable of cell scaffolding. Therefore, an adhesion / electric connection coating with good biocompatibility, PECVD compatibility and electrochemical stability needs to be [...]
Novel biomaterials design rarely incorporates the range of topographical (10nm – 100um) and chemical cues required to influence cell behaviour. Of particular interest is controlling human mesenchymal and embryonic stem cell fate. Recently it has [...]
Fullerenes are considered to be the world’s most efficient radical scavenger, and represents an attractive tool for biological applications. Indeed, it have been demonstrated in vivo and in vitro, that fullerenes and related structures reduce [...]
To develop an efficient magnetic system for separation of CD4+ lymphocytes, we design a simple, specific, and cost-effective CD4 separation system without the need for column separation technique. Novel immunomagnetic particles have been prepared for [...]
Bacterial cellulose (BC) has established to be a remarkably versatile biomaterial and can be used in wide variety of applied scientific endeavors, especially for medical devices. In fact, biomedical devices recently have gained a significant [...]
Bacterial infection is one of the common clinical problems which can be prevented by coating the surgical instruments or implants with antibacterial properties. The high incidence of infections caused by either fungal or bacteria on [...]
Pectin functionality is largely dependent on the ratio of methylesterified/demethylesterified galacturonic acid (GalA) residues present in its polymeric homogalacturonan region (40 – 60 nm in length, 100 – 150 GalA residues) and how the two [...]
We proposed a synthetic strategy for producing hybrid bionanomaterials based on nanocrystalline TiO2 and catechol-grafted polymers. A sol-gel process in organic solvent was developed to grow TiO2 nanocrystals of highly controlled size and surface chemistry, [...]
Journal: TechConnect Briefs
Volume: 3, Nanotechnology 2011: Bio Sensors, Instruments, Medical, Environment and Energy
Published: June 13, 2011
Industry sectors: Advanced Materials & Manufacturing | Medical & Biotech