Auburn University – TechConnect Briefs

Precise Phage-navigating Metastatic Breast Cancer-targeted Paclitaxel-Micell Nanomedicines

Petrenko V.A., Torchilin V.P., Auburn University, US

Breast cancer is one of the most common cancers in the USA. Despite the increase of relative survival rate of women with breast cancer for the last decades, it is still low (~26%, 5 years) [...]

Self-navigating drug delivery nanovehicles driven by polyvalent multifunctional phages and their promiscuous proteins

Gillespie J.W., Petrenko V.A., Auburn University, US

Development of precision medicines acting specifically at the site of disease has been a long sought goal for the last century, starting from pioneering works of Paul Ehrlich, who suggested the concept of site-directed chemotherapeutics [...]

Molecular toolkits for engineering of self-navigating drug delivery vehicles

Gillespie J.W., Petrenko V.A., Auburn University, US

Analysis of multi-thousand clone populations of the cancer cell-binding landscape phages and their multi-motif proteins using massively parallel sequencing techniques allowed the discovering of a variety of short motifs serving as elementary binding units during [...]

A Physics Based Approach to Compact Modeling of Noise in Modern Bipolar Transistors

Niu G., Auburn University, US

A physics based approach to compact modeling of bipolar transistor noise is described. Frequency dependent intrinsic base current noise, its correlation to intrinsic collector current noise, avalanche of intrinsic collector current noise entering the collector-base [...]

Controlling Alignment in Cellulose Nanocrystal Coatings

Ashurst R.W., Davis V.A., Haywood A.D., Auburn University, US

Investigations on the rheology and phase behavior of aqueous CNC dispersions have been used to develop processes for making CNC coatings with controlled properties. We report how the interplay between dispersion microstructure, shear, and drying [...]

Phase Behavior and Macroscopic Processing of Single-Walled Carbon Nanotube – Lysozyme Dispersions

Davis V.A., Horn D.W., Auburn University, US

Lysozyme (LSZ) facilitates the dispersion of single-walled carbon nanotubes (SWNT) while maintaining its’ antibacterial activity through macroscopic processing. The structural and enzymatic nature of LSZ makes possible the dispersion of SWNT for processing into macroscopic [...]

CFD-Assisted Design and Optimization of a Pharmacokinetic Microfluidic System

Cramer K.A., Hamon M., Hong J.W., Khodadadi J.M., Moeini Sedeh M., Auburn University, US

In this research, a microfluidic system was designed and optimized to carry out in vitro pharmacokinetic studies of drug candidates in the liver. Computational fluid dynamics (CFD) was called on to assist in the system [...]

Numerical Simulation of the Solidification of Water-Based Nanofluid

El Hasadi Y.M.F., Khodadadi J.M., Auburn University, US

Nanofluids are colloidal suspensions which they consist particles in the size range of 100-1 nm. In the recent years nanofluids kept the attention of the scientific community due to their improved thermal physical properties compared [...]

Prediction of Thermal Conductivity of Liquid Methane/Ethane-Cu Nanofluids via Molecular Dynamics Simulations

Babaei H., Khodadadi J.M., Auburn University, US

The improvement of thermal conductivity by suspending nanoparticles in two hydrocarbon-based nanofluids is investigated by means of molecular dynamics simulations. Base fluids are methane and ethane and nanoparticles are pure copper. Two temperatures for which [...]

An Experimental Determination of Temperature-Dependent Thermal Conductivity of Cyclohexane-Based Nanofluids

Fan L., Khodadadi J.M., Auburn University, US

In extending their applicability , utilization of nanofluids as superior solid-liquid phase change materials (PCM) for thermal energy storage has been proposed recently. This extension of potential utility of nanofluids will require thermal conductivity measurements [...]