Weller H. – TechConnect Briefs

Uptake Behavior of Glycoconjugated and Micellar-Encapsulated Quantum Dots on HeLa Cervical Cancer Cells

Alpers D., Kreuziger A.-M., Mattoussi H., Merkl J.-P., Muroski M., Ostermann J., Safi M., Schmidtke C., Strouse G., Tran H., Weller H., University of Hamburg, DE

Glyconanomaterials are of great interest for bio-imaging to understand biological processes, for instance metabolism, cell-cell or virus-cell interactions, gluconeogenesis, and cancer. Herein, we present a strategy for the biofunctionalization of fluorescent quantum dots (QDs) from [...]

Fluorescent-Plasmonic Quantum Dot-Gold based Nanohybrids: Basic Research for Next Generation Materials and Tracking of Biological Events

Aldeek F., Bals S., Feld A., Heidari H., Kloust H., Lange H., Mattoussi H., Merkl J.-P., Safi M., Schmidtke C., Strelow C., Weller H., University of Hamburg, DE

A novel hybrid nanoparticle is presented based on encapsulated fluorescent CdSe/ZnSe/ZnS core/shell/shell quantum dots (QDs) with zwitterionic capped gold nanoparticles (AuNPs). This hybrid is fully characterizes by variouse techniques including optical spectroscopy, (cryo) transmission electron [...]

Synthesis of Ultra Small Biocompatible Magnetic Nanocomposites by Seeded Emulsion Polymerization

Kappen S., Kloust H., Kornowski A., Moritz H.-U., Pauer W., Pöselt E., Schmidtke C., Weller H., University of Hamburg, DE

We present the production of PEGylated particles in the lower nanometer range by a new seeded emulsion polymerization technique under micro-emulsion conditions, avoiding any treatment with high shear forces or ultrasonication. Hereby, the hydrophobic shells [...]

Encapsulation of nanoparticles with multifunctional, cross-linkable diblock copolymers for biomedicine

Becker S., Kloust H., Kreuziger A., Niehaus J., Ostermann J., Pietsch A., Pöselt E., Schmidtke C., Tran H., Weller H., Werner K., University of Hamburg, DE

We would like to present a micellular encapsulation method for nanoparticles (quantum dots, iron oxides, gold) which is based on a ligand exchange procedure of native ligands with a prepolymer poly(isoprene)-diethylentriamine (PI-N3) and subsequent ligand [...]

Water-soluble nanoparticles as an universal imaging tool

Becker S., Ness D., Niehaus J., Schmidtke C., Weller H., Werner K., Center for Applied Nanotechnology, DE

Here we present a two step concept for phase transfer of NPs soluble in non-polar media. The first step is an exchange of the stabilizing organic molecules against a multidental binding short chain polymer. In [...]

Highly stable and orientationally coupled gold nanoparticle antibody conjugates for sensitivity improvement in LFIA

Ijeh M., Vossmeyer T., Weller H., University of Hamburg, DE

LFIAs are used in the investigation of a variety of bio-molecular binding interactions and they remain the primary means for point of care and fast detection of analytes including pathogens and toxins. In a novel [...]