siRNA and Paclitaxel Loaded PEG-PCL-PEI Tri-block Polymeric Micelle for Gene and Chemo-therapy Applications in Multidrug-resistance cancer cell


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An annoying problem of chemotherapy was the drug resistance of cancer cell which was expression of multidrug-resistance associated proteins and resulted in ineffective treatment. To conquer this problem, a small interfering RNA (siRNA) molecule and paclitaxel (PTX) were used as gene and chemo-therapy drug to make drug resistance cancer cell sensitizing to chemotherapeutic drug. For achieving the mentioned objective, tri-block copolymer, polyethylene glycol-polycaprolactone-polyethylenimine (PEG-PCL-PEI) forming micelle was utilized to encapsulate the PTX in the core of micelle and to attract the siRNA on the corona of PEI in this study.

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Journal: TechConnect Briefs
Volume: 3, Nanotechnology 2011: Bio Sensors, Instruments, Medical, Environment and Energy
Published: June 13, 2011
Pages: 225 - 228
Industry sectors: Advanced Materials & Manufacturing | Medical & Biotech
Topic: Biomaterials
ISBN: 978-1-4398-7138-6