Materials for Drug & Gene Delivery

Gene Delivery and Transfection in Human Pancreatic Cancer Cells using Epidermal Growth Factor Receptor-Targeted Gelatin Nanoparticles

Xu J., Amiji M., Northeastern University, US

More than 32,000 patients are diagnosed with pancreatic cancer in the United States per year and the disease is associated with very high mortality. Although gene therapy has tremendous promise, the major challenge has been [...]

Plasmonic Nanobubbles for Intracellular Targeting and Gene Therapy

Lukianova-Hleb E., Wen J., Meteletsa L., Brenner M., Chang J., Lapotko D.O., Rice University, US

Intracellular molecular targeting (IMT) and gene transfection of eukaryotic cells is widely used for research and for developing gene cell therapy. However, the existing IMT methods lack selectivity, efficacy and safety when heterogeneous cell systems [...]

Spectrally-Selective Light-Induced Release from Gold-Coated Liposomes

Leung S.J., Romanowski M., University of Arizona, US

To address unmet medical needs in the area of controlled delivery, we recently presented liposome-supported plasmon resonant gold nanoshells. These composite structures are degradable into components of a size compatible with renal clearance, potentially enabling [...]

Liposomes loaded with rifampicin and tobromycin for anti-Staphylococcus aureus action

DeSilva M.N., Zhao W.W., Schultz S.T., Whang K., Chu L., Naval Medical Research Unit San Antonio, US

Reducing patient recovery time and potential post surgical complications of warfighters after traumatic injury is of importance for the military. However, a current medical challenge in treating warfighters with traumatic injuries is bacterial infection due [...]

Layer-by-Layer Deposition of Cationic Polymers on Gold Nanoparticle for Non-viral Gene Delivery System

Saengkrit N., National Nanotechnology Center (NANOTEC), TH

In this study, gold nanoparticles displayed spherical shapes with an average size of 12 nm were synthesized. The nano-carriers for gene delivery were subsequently developed based on DNA adsorption on the gold/cationic polymer-scaffold. The multilayer [...]

beta-casein micelles and nanocapsules in drug delivery

Khalfin R.L., Bachar M., Danino D., Technion – Israel Institute of Technology, IL

β-casein, the main protein found in milk, is an amphiphilic molecule that forms micelles both above and below the pI. In the presented work we investigated the possible use of β-casein micelles as a vehicle [...]

Nanoparticulate systems of Acyclovir for Topical use in Herpes treatment –formulation, characterization and evaluation

Srinivas P., Devaraj R., Sri Venkateshwara College of Pharmacy, IN

Of the numerous drugs that are available for systemic treatment of HSV infection, a cream containing an antiviral agent is still the most convenient method of treating herpes simplex labialis/facialis in the general population. Acyclovir [...]

Biodegradable micro and nanoparticles for controlled drug release

Mattu C., Sartori S., Ranzato E., Boffito M., Li R., Ciardelli G., Politecnico di Torino, IT

Biodegradable polymeric micro and nanoparticles have shown to be promising forms for the delivery of a wide array of drug formulations, such as hydrophobic or hydrophilic active principles, proteins or other bio molecules. The aim [...]

Cationic Nanoparticles Effectively Delivered VEGF SiRNA in A549 Cells

Yang T., Li X., Liu Y., Liu Y., Bai S., Husson University, US

Recent discovery of small interfering RNA (SiRNA) that silences growth factors appears to improve effectiveness and safety of cancer therapy. Unfortunately, delivery of SiRNA to cancer cells is a major obstacle. Our work is focused [...]

Enhanced bioavailability of peptide YY using nanoporous silicon as a drug carrier

Kovalainen M., Monkare J., Makila E., Salonen J., Lehto V-P, Herzig K-H, Järvinen K., University of Turku, FI

Biomedical applications of inorganic nanomaterials have been actively investigated during the last years. Porous silicon (PSi) is one of those new promising materials possessing several attractive properties. It is biodegradable and considered to be safe [...]

Synthesis and Characterization of Superparamagnetic Nanoparticles Coated with Carboxymethylated Cassava Starch for Drug Delivery System

Kasemwong K., Nanta P., Skolpap W., Ruktanonchai U.R., Nano Delivery System Laboratory, National Nanotechnology Center, TH

Magnetic nanoparticles (MNPs) are increasingly being considered for a number of biomedical applications due to their inherent ultra fine size, biocompatibility and superparamagnetic properties. The functional properties of the MNPs can be tailored for specific [...]

Nanosized titania reservoirs for epilepsy treatment

Kozina A., Espinoza K.A., Ortiz-Islas E., Rivero I.A., Lopez T., Instituto Nacional de Neurologia y Neurocirugia ‘MVS’, MX

Around 50 million people in the world suffer from epilepsy. Although there is no cure for this disease, with the right type and dosage of anti-epileptic medication the majority of patients can have their seizures [...]

UltraDOTs : Multifunctional Ion-Selective Delivery Capsules

Walters J.D., Hall E.A.H., University of Cambridge, UK

Emerging from the sensing capabilities of the particle sensors, we have developed a platform technology to produce a family of monodisperse capsule structures ranging from the nano to the micro in their diameters and shell [...]

PEG Incorporated Polymeric Microcapsules for Intramyocardial Delivery of Stem Cells Genetically Modified by Baculovirus

Paul A., Khan A.A., Abbasi S., Shum-Tim D., Prakash S., McGill University, CA

The ability of mesenchymal stem cells to self-renew and differentiate into specialized cell lineages makes them promising tools for regenerative medicine. Local injection and use of scaffolds had been employed earlier to deliver these cells; [...]

Synthesis, Characterization and Antibacterial Activity of Glycol Chitosan Modified Superparamagnetic Nanoparticles

Chen B.H., Inbaraj B.S., Fu Jen University, TW

Superparamagnetic iron oxide nanoparticles (IONPs) are particularly attractive as antibacterial agents owing to their precise bacterial biofilm and cell targeting in vivo achieved by magnetic driving. In this work, superparamagnetic IONPs modified with water-soluble glycol [...]

A Non-toxic Cellular Staining Agent Based on Fluorescently Labeled Poly[2-(methacryloyloxy)ethyl phosphorylcholine]

Warren N.J., Massignani M., Armes S.P., Battaglia G., Lewis A.L., The University of Sheffield, UK

The biocompatible monomer 2-(methacryloyloxy)ethyl phosphorylcholine (MPC) is polymerized by atom transfer radical polymerization (ATRP) using a fluorescent ATRP initiator and fluorescent comonomers. In this study we show that PMPC alone can be used as a [...]

Encapsulation and in vitro characterization of protein in PLGA-chitosan nanoparticles for efficient protein delivery

Subbarayan P., Dennis V.A., Lee C., Nyairo E., Singh S.R., Alabama State University, US

Respiratory Syncytial Virus (RSV) is one of the most common causes of severe respiratory tract infections affecting mainly elderly, infants and the immunocompromised worldwide. As yet, a safe and effective vaccine has not been developed [...]

Concentration and characterization of influenza antigen bulks for potential novel vaccine delivery applications

Scampini A., Gallorini S., Baudner B.C., Palladino G., Singh M., O’Hagan D.T., Kommareddy S., Novartis, US

As a part of reformulating influenza vaccines by novel delivery technologies it is essential to work with concentrated antigens. The purpose of this study was to concentrate seasonal influenza monobulks, to characterize the concentrated antigens [...]

Nanoencapsulated Drug-Carrying System for Photodynamic Antimicrobial Chemotherapy (PACT)

Kalapala G.K.M., Fu P.K.-L., Governors State University, US

Chronic wounds are considered as a pandemic health problem. Approximately 1% to 2% of the population in developing countries has experienced a chronic wound during their lifetime. In the United State States,the expense of treating [...]

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