Fluorescent nanodiamonds (FNDs) are a new category of nanoparticles with optical properties that make them superior imaging probes that could replace commonly used fluorescence agents (i.e. dyes and quantum dots). In particular, their near infrared [...]
The use of nanoparticles to deliver magnetic resonance (MR) contrast agents to enhance MR sensitivity has shown great potential in identifying and diagnosing diseases such as cancer and cardiovascular disease. A common challenge is the [...]
One-pot synthesized polyacrylic acid-modified iron oxide (PAAIO) was decorated with a polymer, which was served as a reservoir for a therapeutic agent or a fluorescent dye via chemical or physical approaches. PAAIO possess specific magnetic [...]
Accurate, noninvasive techniques for monitoring bone-implant integration are demanded in clinic. Standard X-ray and CT provide a snapshot of the skeletal structure. However, metal artifact is an unsolved problem to visualize the CT image detail [...]
This paper addresses various aspects in the development of the new imaging technique, colloid vibration potential imaging. Two theoretical models are introduced, including an extended (2D) slab model and a 3D electric dipole model. These [...]
, Fortin M.-A.
, Gossuin Y.
, Guillet-Nicolas R.
, Kleitz F.
, Lagueux J.
, Laprise-Pelletier M.
, Laurent S.
, Vander Elst L.
, Université Laval, CA
Biocompatible and high porosity mesoporous silica nanoparticles (MSNs) represent a significant advance in drug delivery applications, currently entering clinical validation. It will be necessary to track these drug vectors over time with medical imaging techniques. [...]
Biologists for years have been trying to visualize the movement and action of proteins and other molecules in and around cells and tissues. Transgenic way of attaching green fluorescence proteins started to help in such [...]
Label-free optical sensors have recently emerged as a highly sensitive approach for detecting a broad range of chemical and biological analytes that include illicit drug compounds, explosives, proteins, viruses, and bacteria.To best meet such diverse [...]
We present a new on-chip, isothermal signal amplification technique for direct detection of unmodified DNA and RNA on microarrays using terminal deoxynucleotidyl transferase (TdT), a template-independent DNA polymerase that catalyzes the sequential addition of deoxynucleotides [...]
Thiol-functionalised gold nanoparticle chemiresistors can respond to low-molecular weight chemicals through changes in electrical resistance. This low-cost sensor technology is currently being developed for multiple applications including water quality, microbial metabolomics, environmental monitoring, and point-of-care [...]
Dynamic nanomechanics and nanostructures of dividing and anti-mycobacterial drug treated mycobacterium are yet to fully elucidate. Atomic force microscopy (AFM) is a promising nanotechnology to characterize such dynamic properties, especially at the single cell level. [...]
In previous reports, we have successfully fabricated biosensors that could measure chemical species that are important in environmental monitoring, as well as metabolites that are indicators of the proper functioning of our body. In our [...]
Development of biosensors for medical applications is an on-going research field of great importance. In particular localized surface plasmon resonance (LSPR) biosensors show a high potential to detect analytes at low concentrations in biological fluids. [...]
Our research group is in the quest of developing a biosensor platform that is fast in response time, versatile that can be used to detect a variety of chemicals species and metabolites, and ultra-sensitive that [...]
Alzheimer’s disease (AD) affects millions of people around the world with rising incidence as population age. Here we present the use of a label/label free silicon/silicon oxide (Si/SiO2) based microarray platform to develop a highly [...]
This study reports a novel non-invasive technique for the detection of skin health conditions using gold nanoparticles (GNP). The feasibility of the use of these GNP in the diagnosis of skin health conditions was non-invasively [...]
, He R.
, Jin J.
, Li J.
, Liu X.
, Sun B.
, Xing G.
, Zhang M.
, Zhao Y.
, Chinese Academy of Sciences, CN
Fullerenols were known as the major water-soluble derivatives of fullerene that possess particular signiﬁcance biological effects such as anticancer active and free radical scavengers. We have reported a novel method for purifying nanoparticles of fullerenols, [...]
This study aims at developing a nanotechnology-based screening test that would reliably detect early stage tuberculosis (TB) infection and discriminate active from latent infections. The use of urine in TB testing has been hampered by [...]
Designing small scale integrated systems for sensing and actuation has gained lots of interest in recent years. Currently, subsystems are fabricated separately and then bonded together to form an integrated platform. This poses a fundamental [...]
The therapy of manic depressive psychosis with lithium salts requires periodic measurements of the Li concentration in whole blood, plasma, urine or serum. The analysis is difficult because of the low lithium concentration compared to [...]
We have developed a novel technique for specific amplification of rare methylated DNA fragments in a high background of unmethylated sequences that avoids the need of bisulphite conversion. The methylation-dependent restriction enzyme GlaI is used [...]
We present the design and development of a continuous flow quantitative Polymerase Chain Reaction system, suitable for multi-analyte, high-throughput, semi-autonomous assays. This system operates in a continuous fashion and is able to detect many different [...]
A realistic temperature sensing alternative for life-science objects could be the process of triplet-triplet annihilation upconversion in water environment (TTA – UC): It is inherently micro-scale sensing techniques – the sensing function is carried out [...]
Imperfections of the MALDI ionization process of proteins and peptides impose considerable limitations on the utility of mass spectrometry in basic life sciences and ultimately on the application in biomarker discovery and medical diagnostics. Improved [...]
The presentation will illustrate how redox proteins can be arranged in multiple layers on electrodes while retaining full electroactivity without the use of mediators. Enzymes can be integrated into such systems to result in sensing [...]
Multi-layer tablets, combination drug formulations and other innovative dosage forms are getting increasing attention in pharmaceutical industry. As structure and composition of the multi-layer dosages become more complicated, the development and application of techniques for [...]
Nowadays quantum dots (QDs) technology is most commonly used in medical application as a probe to diagnostic procedures and also for designing of biosensors. However, the application of this technology is very new in food [...]
In recent years, the stability of proteins in solution has attracted significant scientific and commercial interest due to the exponential growth in the use of proteins as biotherapeutic drugs. Since knowledge of formulation stability and [...]
Antibiotics represent one of mankind’s most important medical inventions, yet antibiotic resistance has emerged as a significant health-care problem due to the extensive use and misuse of antibiotics in human and veterinary medicine. Suppressing the [...]
We report a new approach to study Direct Electron Transfer (DET) rate constants between an electrode surface and an active biomimetic receptor using four types of gold nanobiomimetic sensors. The goal is to find the [...]
DNA-carbon nanotube hybrids (DNA-NT) consist of single stranded DNA self-assembled to the sidewall of single-walled carbon nanotubes. DNA-NT show great promise for applications in nanotechnology, including chemical sensing and sequence-specific DNA detection. Details of the [...]
Tuneable resistive pulse sensors (TRPS) have generated considerable interest for their ability to accurately characterize the size, charge and concentration of nano to micro-scale particulate suspensions. Measuring the properties of each particle (e.g. exosome, virus, [...]
We describe a simple, miniature, wireless device that can accurately measure pressure fluctuations in the limb compartments of patients at risk of developing ACS. We plan to use temporary indwelling, direct pressure sensors consisting of [...]
We have designed a dual-aptamer complex specific to both prostate-specific membrane antigens (PSMA) (+) and (–) prostate cancer cells. In the complex, an A10 RNA aptamer targeting PSMA (+) cells ¬¬and a DUP-1 peptide aptamer [...]
A method for in-vitro detection of bioanalyte using conductive microstructures to accelerate magnetic nanoparticles (MAPs) in an integrated microfluidic system is presented. The fundamental idea behind the elaboration of such a biosensing system is that [...]
Melamine is a nitrogen-rich compound widely used in plastics industry. Due to its high nitrogen content and low cost, it has been illegally added to food products to boost apparent protein content. Conventional methods to [...]
There is a growing interest in the health risk posed by endocrine-disrupting chemicals (EDCs). Detection and monitoring of water sources for steroidal EDCs relies on a laborious analysis of their chemical structures. It is also [...]
Current methods for detecting water-borne pathogens require a laboratory setting, analyte preparation and typically a day or more. The author, a solid state device physicist, has invented a methodology capable of the real-time (1 - [...]
Journal: TechConnect Briefs
Volume: 3, Nanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy (Volume 3)
Published: May 12, 2013
Industry sector: Medical & Biotech
Topicss: Diagnostics & Bioimaging, Sensors - Chemical, Physical & Bio