Wang M. – TechConnect Briefs

A Novel, Clear Fire Retardant Waterborne Coating System for Wood Substrates

Hughes J., Wang M., Zhang L., Armstrong World Industries, US

Clear intumescent coatings were developed to allow for presentation of the natural wood visual, but have struggled to achieve an acceptable E84 Class A rating, while also having a plastic-type look to the visual. Many [...]

Two-Dimensional Nanoporous Silicates and Their Potential Applications

Zhong J.Q., Kestell J., Akter N., Kim T., Wang M., Lu D., Galuskina I., Stacchiola D.J., Boscoboinik J.A., Brookhaven National Laboratory, US

Ultra-thin two-dimensional inorganic nanoporous silicates have been recently synthesized. They are as thin as 0.5 nm, can be produced in the form of ordered structures or glasses and doped with other elements, such as aluminum. [...]

Methods of colloid vibration imaging for characterisation of nano-particle suspensions

Wang M., Hosseini M., Bramson L., Khan J.I., University of Leeds, UK

This paper addresses various aspects in the development of the new imaging technique, colloid vibration potential imaging. Two theoretical models are introduced, including an extended (2D) slab model and a 3D electric dipole model. These [...]

An Integrated Microfluidic Real-Time PCR System for Pathogen Detection

Zhu L., Li L., Li Z., Lin F., Liu Y., An D., Wang M., Wang Y.K., Zhang G., Zhang L., Wang M., Wang Y.K., Li L., Li Z., Lin F., Liu Y., Liu Y., Zhang G., Zhang L., Lin F., University of Manitoba, CA

The development of microfluidics-based PCR for rapid genetic analysis particularly pathogen detection is an emerging research field. Recent advancement of microfluidics critically enabled the development of various on-chip PCR systems to realize its apparent advantages [...]

Lyceum Chinense and Calcium Phosphate Nanoparticles for Ophthalmic Drug Delivery

He Q., Fang Z., Wang M., Xu Q.W., Chen R., Zhang X.Z., Yaun W.M., Zhau D.M., Wu Jian, Morehouse School of Medicine, US

Glaucoma, the leading cause of irreversible blindness in the world, is estimated to be affected by 67 million people. It is characterized by an increase in intraocular pressure (IOP). Carbonic anhydrase inhibitors (CAIs) are orally [...]

Organisation of peptide ligands on the surface of gene vectors

Wang M., Miller A.D., Thanou M., Imperial College London, UK

Through the considerate organisation of surface ligands, we have developed a lipid-based vector for the targeted delivery to cancer cells. Our ligand is a short peptide with high affinity for the Urokinase Plasminogen Activator receptor [...]

Utility of Customized Targeted PEG Linkers for the delivery of oligonucleotides without the use of transfection reagents

Zhao H., Reddy P., Xia J., Wang M., Sapra P., Bandaru R., Belen Rubio M., Wu D., Zhu P., Filpula D., Greenberger L.M., Horak I.D., Enzon Pharmaceuticals, Inc., US

Delivery of LNA oligonucleotides using Customized Targeted PEG linkers has improved the in vitro cellular uptake into cancer cells. Customized Targeted PEG linker-LNA conjugates can knock down target mRNA in a concentration dependent fashion with [...]

Oral Delivery of Map4K4 siRNA to Macrophages Inhibits TNF alpha Production and Protects against a LPS-Galactosamine Challenge in Mice

Aouadi M., Tesz G., Soto E., Wang M., Nicoloro S., Ostroff G., Czech M., University of Massachusetts Medical School, US

RNA interference (RNAi) is a new, promising approach to selectively regulate gene expression through modulating mRNA stability and translation. However, the efficient delivery of 21 mer dsRNA molecules (siRNA) to affect RNAi remains a challenge. [...]

Novel lithography technique using an ASML stepper/scanner for the manufacture of display devices in MEMS world

Best K., Raval P., Kappel N., Yang C., Wang M., Jeewakhan N., Prejda M., Kassekert K., Moore M., ASML USA, Inc - Special Applications, US

In the MEMS and MOEMS product world, manufacturer of display/micro-devices requires bonding of two wafers. The front side pattern of the top wafer needs to be aligned with aggressive overlay requirement with the remaining portion [...]

Temperature Uniformity and DNA Amplification Efficiency in Micromachined Glass PCR Chip

Huang C-C, Wang M., Liu W-P, Weng K-Y, Yao L-Y, Industrial Technology Research Institute, TW

We have fabricated glass-based micromachined DNA polymerase chain reaction (PCR) chips with different heater patterns. Two pieces of Pyrex 7740 glass are thermally bonded together to form the PCR reaction channel. The PCR channel was [...]