We present a chip-based bio-analysis system using the two dimensional (2D) magnetic manipulation of microdroplets. The latter contain magnetic microparticles which serve as force mediators for the droplet actuation. In combination with a changeable field [...]
A novel laser driven peristaltic micro-pump for the manipulation of fluids in a micro system has been explored and validated on whole blood in saline solution. The pump is based on laser-induced film-boiling of the [...]
Ultrasonic and dielectrophoretic particle manipulation has been studied for particle trajectory modification and particle trapping in microfluidic channels. We report a new approach of a combination of dielectrophoresis (DEP) and ultrasonic fields to trap and [...]
Blood displays interesting behavior when flowing through channels with dimensions similar to the blood cells. Two well-known examples include the decrease in flow resistance with tube size (Fahraeus-Lindqvist effect) and the enhancement of leukocyte (WBC) [...]
We present a new dynamic contact angle model applied to the fillingproblem in microfluidic devices. The level-set method is used forinterface capture. Several attempts have been made in the past decades to model contact--line dynamics [...]
We present the first transient pressure measurements and high-speed visualizations of a gas bubble passing through liquid-filled microchannel contractions. Results are compared with a simple theoretical model taking into account the Young-Laplace pressure drop, the [...]
, Domínguez P.
, Egatz-Gomez A.
, García A.A.
, Gust D.
, Hayes M.
, Lindsay S.
, Melle S.
, Picraux T.
, Rubio M.A.
, Taraci J.
, Arizona State University, US
We present a novel method to control water drop movement on superhydrophobic surfaces through magnetic fields. Water drops with paramagnetic particles can be moved on fractal Si-nanowire superhydrophobic surfaces at high speeds by displacing a [...]
This paper demonstrates the electrokinetic flow and transport of charged and neutral analytes in nanochannels by solving full system of governing Poisson-Nernst-Planck equations without any assumptions. The issues related to the spatial and time scales [...]
Efficient mixing to promote chemical reactions is extremely desirable in lab-on-a-chip microfluidic devices, but is difficult to achieve in the typical low Reynolds-number flows. Numerical simulation of the high Peclet-number case common in microfluidics is [...]
Our work aims to develop multi-scale computational procedures for simulating the dielectrophoretic behavior of biomolecules in micro- and nano-electrofluidics, which combine electrohydrodynamics with molecular theories for the macromolecule polarization caused by the distortion of the [...]
In this paper, we present a methodology of generating microfluidic macromodels (reduced-order models) for 3-D non-linear microchannels. Compared with the full-meshed simulations, the generated macromodels not only provide accuracy results, but also give three-orders-of-magnitude speed-ups. [...]
We present a simple silicon-based fabrication technique for nanocapillaries based on controlled growth of silicon-dioxide, UV lithography, etching with etch-stop, and glass wafer bonding. Our approach improves state-of-the-art with respect to the obtained cross-wafer homogeneity [...]
In this paper, we present design methodologies for magnetohydrodynamic (MHD) complex flow generation in a simple straight microchannel in which electrodes are patterned on two side walls and bottom wall. The required applied voltage conditions [...]
A hybrid design tool combining one-dimensional(1D) lumped parameter model and three-dimensional(3D) computational fluid dynamics (CFD) approach has been developed and applied to industrial inkjet head design for the application of direct writing on printed circuit [...]
Liquid microjets are inherently unstable and can be broken into droplets in a controllable fashion via thermal modulation of surface tension. Such modulation can be achieved using CMOS/MEMS technology by integrating resistive heating elements around [...]
In our work we describe a new approach to measure pH differences in microfluidic devices and demonstrated acidification rate measurements in on-chip cell culture systems with nanoliter wells. We used two miniaturized identical iridium oxide [...]
A microfluidic device designed and optimized for the multi-step synthesis of PET (Positron Emisssion Tomography) probes is presented. It is the first device in its class to produce radiopharmaceuticals of sufficient quality and quantity (over [...]
While lab-on-a-chip (LoC) systems are increasingly used in the areas of genomics, proteomics and drug discovery, their efficient simulation and design at system-level continue to be a challenge. Experimental trial-and-error and multiphysics-based high fidelity computation [...]
Microfabricated platforms that allow automated cultivation and behavioral observation of Caenorhabditis elegans would be a valuable tool in physiological and genetic studies. Here, we report an automated microfluidic compact disc (CD) system conducive to the [...]
DNA repair enzyme analysis on EWOD fluidic microprocessor An original analytical assay, aimed at monitoring DNA lesions repair activities has been combined to a dedicated microfluidic EWOD (electrowetting on dielectric) microprocessor.The quantification of enzymatic repair activities [...]
Measuring ligand receptor forces using the atomic force microscope as a force-sensing instrument has been well documented. For example in the detection of antibody-antigen interactions with the antibody attached to the AFM tip with a [...]
, Alessi E.
, Amore M.G.
, Conoci S.
, Di Francesco F.
, Di Pietro P.
, Di Trapani G.
, Iacono G.
, Palmieri M.
, Petralia S.
, Ricceri D.
, San Biagio F.
, STMicroelectronics, IT
Nucleic Acid Testing (NAT) represents one the most sensitive and effective method for several applications in the molecular diagnostic area, including clinical, industrial, veterinary and research applications. In this context, the development of miniaturized devices [...]
, Cong S.
, Guan H.W.
, Hood L.
, Johnson E.
, Kim G.
, Lasky S.
, Nishimoto A.
, Petcavish B.
, Lumera Corporation, US
A high resolution surface plasmon resonance (SPR) microscopy technique based on the combination of Lumera’s polymer and proprietary optic technologies offers parallel high-throughput analysis of biomolecular binding kinetics on high-density antibody microarrays ( > 1,500 [...]
We present a novel design of a continuous microfluidic sorter for separation of cells or particles by the intelligent use of conventional negative dielectrophoresis with separation efficiency of greater than 95%. A high fidelity modeling [...]
AC electroosmotic pumping of fluids is studied in the model consisting of two thin coplanar electrodes, deposited on a dielectric substrate and placed in an aqueous solution. An AC voltage is supplied to the electrodes [...]
Microfluidic systems operate in a pressure driven flow regime with no moving parts to drag the fluids. Our research aims at developing rigorous assessment and quantification tools of mixing in microchannels. The tools are based [...]
Lateral flow “strips” are a common assay format used in a variety of applications, including home pregnancy testing, clinical point-of-care screening for HIV, agribusiness surety against pathogens, and military bioagent detection. Current lateral flow assays [...]
We present a microfluidic particle concentrator and separator employing a large flow unit array. Each flow unit includes a nozzle, a sharp turn, a diffuser, and a flow dividing segment. After acceleration in the nozzle, [...]
A flow-through micro polymerase chain reaction (PCR) chip was optimized by using coupled multiphysics computational tools. Comprehensive simulations of temperature and flow profiles were presented for the denaturation, extension, and annealing zones on the flow-through [...]
Estimations of apparent diffusion coefficients usually consist of curve-fitting the output of one-dimensional models to experimental laboratory-measured data from porous aggregates shaped in different forms. In this research a computational exploration is presented on the [...]
The design of PZT actuated valveless membrane micropumps is a very complex process as it involves the knowledge of electro mechanics, solid mechanics and fluid mechanics. So far, there is no accurate, flexible and broadly [...]
When metal or oxide nano particles are dispersed in fluids to form nanofluids, the particles will improve the thermal conductivity of the fluids. Therefore, it is suggested to use nanofluids as coolant to improve heat-exchanger [...]
In this work, we developed a microfluidic assay for determination of the individual cell’s response to chemical exposure. Microfluidic chips comprisd four channels were fabricated on polystyrene (PS) substrates via mechanical milling processes, and covered [...]
We show that internal mixing within a sessile liquid drop can be significantly enhanced by means of so-called electrowetting-on-dielectric (EWOD), using an alternating electric potential. This is done experimentally by comparing the coalescence and mixing [...]
Conventional and traveling-wave dielectrophoresis in suspensions are proven techniques for the manipulation, separation, and characterization of suspended particles with potential applications ranging from biological warfare agent detection to healthcare industry. In contrast to previous studies, [...]
experimental visualization, bubble generation and breakup, T-junctions, microchannels
We will report on our recent advances made in predicting this class of flow, using the Level Set approach, in which we have incorporated phase-change capabilities, surface tension and triple-line dynamics models based on the [...]
A novel micromanipulation method using Magnetotactic Bacteria to push micro-objects is proposed. The controllability of MC-1 Magnetotactic Bacteria in micro-channels is verified through microfluidic device with implemented micro-electromagets. After introducation of microfabrication procedure and experiment [...]
Rheology and microfluidics are essential and challenging topics in designing microfluidic devices and materials processing. A study of rheological properties (e.g. viscosity) of complex fluids becomes more important in the flow at microscale due to [...]
Shear thickening fluid is developed using sonochemical method which one step process and can be processed from its dry metal oxide powder forms instead of its colloidal solution. The main problem with the current process [...]
The isolation of fetal cells from maternal circulation is the subject of intense research. Fetal cells can be isolated using several enrichment methods, however no technique to specifically isolate and use them for genetic diagnosis [...]
We report the fabrication of solvent-compatible microfluidic devices based on photocurable “Liquid Teflon” materials. The materials are highly fluorinated functionalized perfluoropolyethers (PFPEs) that have liquidlike viscosities that can be cured into highly durable elastomers that [...]
Lubricant flows are usually assumed to be laminar and the lubricatedmetallic surfaces are anticipated to be perfectly flat and references therein). Both assumptions are incorrectwhen it comes to a detailed analysis. Indeed, metallic surfaces arenever [...]
A simple solution to mixing problems in micro fluidic systems was presented in this paper. A T-form microfluidic mixer was designed and tested utilizing pressure disturbances. The performance of the mixer was studied through both [...]
The main objective of the current work is to investigate the thermal performance, in particular Joule heating of polymer microfluidic chips involving electrokinetically driven flows using experimental and numerical methods. Most of the work focused [...]
Lab-on-a-chip devices for cell processing and analysis are increasingly sophisticated and targeting a wider spectrum of scientific research and clinical diagnostic applications. Despite recent advances however, many sample preparation steps, common for macro-scale techniques, have [...]
Mixing of fluid in different geometric scales dominates variety of real life applications ranging from engineering chemicals, food materials, pharmaceutical products to biological organs. In this presentation we will address coupling of continuum scales in [...]
A common problem with high throughput combinatorial chemistry is the inability to easily analyse and track the multitude of molecules produced. This bottleneck is a major problem for the big pharmaceutical companies and other researchers [...]
Piezoelectric thin films are considered emergent materials for integration within Micro Systems Technology (MST) or MEMS devices. The development of suitable measurement facilities to characterise the materials functional properties is complicated by the fact that [...]
Microfabrication technology has been used to create new microfluidics systems for bioanalytical and medical device applications in the last decade. The handling of relatively small amounts of analytes, at significantly lower concentrations, combined with the [...]
More sensitive and reliable microfluidic devices are needed for the detection of the 8-hydroxy-deoxyguanosine (8-OH-dG) DNA adduct, one of the most frequently used biomarkers reporting on oxidative stress. Therefore, we have developed a capillary electrophoresis [...]
An analytical model is described for predicting the transport and capture of magnetic micro/nano-particles in a magnetophoretic microsystem that consists of an array of integrated soft-magnetic elements embedded beneath a microfluidic channel. The elements are [...]
Journal: TechConnect Briefs
Volume: 2, Technical Proceedings of the 2006 NSTI Nanotechnology Conference and Trade Show, Volume 2
Published: May 7, 2006
Industry sectors: Medical & Biotech | Sensors, MEMS, Electronics
Topic: Micro & Bio Fluidics, Lab-on-Chip