University of California Irvine – TechConnect Briefs

Personalized nanomedicine for the treatment of vascular hypertension in polycystic kidney disease models

Pala R., Nauli S.M., University of California Irvine, US

In our current study, we designed a nanomedical device for the treatment of vascular hypertension in polycystic kidney disease (PKD) model through cilia targeting. We generated and compared two different metal and polymer cilia-targeted nanoparticle [...]

Integration of microfluidic chip with Loop-mediated Isothermal Amplification (LAMP) assay for rapid quantification of Enterococcus Faecalis

Han M., Kamalakshakurup G., Lee A.P., Jiang S., University of California Irvine, US

Rapid and sensitive monitoring of water quality can effectively prevent accidental human exposure to waterborne pathogens. In this project, a rapid quantification method was developed for Enterococcus faecalis, a fecal indicator bacteria (FIB), used as [...]

Bioabsorbable Anti-inflammatory Material: A Novel Protein-Conjugated Polymer with Applications in the Implantable Medical Device Field

Rapier C.E., Chen E., Liu W.F., Lee A.P., University of California Irvine, US

Biodegradable/bioabsorbable materials are a relatively new movement in the implantable medical device field. Despite the promise of non-permanent implants, bioabsorbable materials can induce a localized inflammatory immune response. To overcome this limitation, we are combining [...]

Precipitation, Adsorption and Inhibitory Effects of Nano Copper in Wastewater Activated Sludge

Smeraldi J., Rajagopalan G., Cooper W.J., Hosseini T., Rosso D., University of California Irvine, US

Objective of this study is to compare the fate, removal and inhibitory effects of nanocopper (oxide) with ionic copper in activated sludge. Impacts of functionalization (complexation) of nanocopper as well as the mechanism of nanocopper [...]

Precipitation, Adsorption and Inhibitory Effects of Nano Copper in Wastewater Activated Sludge

Smeraldi J., Rajagopalan G., Cooper W.J., Hosseini T., Rosso D., University of California Irvine, US

Objective of this study is to compare the fate, removal and inhibitory effects of nanocopper (oxide) with ionic copper in activated sludge. Impacts of functionalization (complexation) of nanocopper as well as the mechanism of nanocopper [...]

Novel Parameters for Rapid Blood Separation on a Centrifugal Platform

Gorkin R., Kim T-H., Madou M., Cho Y-K, University of California Irvine, US

Centrifugal microfluidic platforms are emerging as strong candidates for advanced integrated clinical diagnostics for such applications as automated immunoassay processing and nucleic acid analysis, however several implementation challenges limit their widespread use today. Purification of [...]

Micromachined Glass-Blown 3-D Spherical Shells as Mechanical Vibratory Elements

Prikhodko I.P., Trusov A.A., Zotov S.A., Shkel A.M., University of California Irvine, US

This paper reports a non-contact experimental characterization of resonant modes in micromachined glass-blown spherical shells, enabling new architectures of vibratory 3-D MEMS for signal processing, timing, and inertial applications. Wafer-scale glassblowing was previously developed for [...]

Self Assembly of Colloidal Gold Nanoparticles on Diblock Copolymer Thin Film Templates

Adams S.M., Ragan R., University of California Irvine, US

Self-assembly of metallic nanoparticles were investigated for the development of field-enhanced chemical and biological detection devices with the capacity to achieve single-molecule level detection resulting from surface enhanced Raman scattering, associated with closely spaced noble [...]

Effect of Source, Surfactant, and Deposition Process on Electronic Properties of Nanotube Arrays

Jain D., Rouhi N., Rutherglen C., Burke P.J., University of California Irvine, US

Carbon nanotubes are currently being sought as a potential candidate in the device research area. However, a scalable manufacturing technology for nanotube devices with appropriate yield, reproducibility, and performance in various metrics (mobility, on/off ratio, [...]

A High Throughput Multi-stage, Multi-frequency Filter and Separation Device based on Carbon Dielectrophoresis

Martinez-Duarte R., Andrade-Roman J., Collado-Arredondo E., Martinez S.O., Martinez-Duarte R., Madou M., University of California Irvine, US

We present a multi-stage, multi-frequency carbon dielectrophoresis (CarbonDEP) device for high throughput filtering and separation applications in the health care and biotechnology fields. CarbonDEP refers to the use of carbon electrodes to induce DEP. Up [...]