Jary D. – TechConnect Briefs

Bedaquiline loaded lipid nanoparticles: a promising candidate for TB treatment

Jary D., Hibbitts A., Lozano-Fernandez T., Pérez D., Lucia A., Ainsa J.A., Codony D., Freire C., Redinger N., Schaible U., Coya Raboso J.M., Tailleux L., Navarro F., CEA-LETI, FR

Increase in antibiotic resistance is a global concern worldwide[1], with 480,000 new cases of multi-drug resistant tuberculosis (MDR-TB) diagnosed each year. Therefore, the goals for the Nanotherapeutics for Antibiotic Resistant Emmerging Bacterial pathogens (NAREB) research [...]

Development and Validation of Characterization Methods for Lipidots® Multifunctional Platform: a Step forward Industrial Transfer

Varache M., Ciancone M., Caputo F., Laffont C., Escudé M., Jary D., Boisseau P., Texier I., Navarro F.P., Couffin A.C., CEA-LETI, FR

For eight years, our research group has been developing lipid nanocarriers, known as Lipidots®, as a multifunctional platform for medical applications. A wide range of active pharmaceutical ingredients (APIs) and contrast imaging agents has been [...]

DNA repair enzyme analysis on EWOD fluidic microprocessor

Jary D., Chollat-Namy A., Fouillet Y., Boutet J., Chabrol C., Castellan G., Gasparutto D., Peponnet C., CEA, FR

DNA repair enzyme analysis on EWOD fluidic microprocessor An original analytical assay, aimed at monitoring DNA lesions repair activities has been combined to a dedicated microfluidic EWOD (electrowetting on dielectric) microprocessor.The quantification of enzymatic repair activities [...]

Mechanical Behavior of Micro-Drops in EWOD Systems: drop extraction, division, motion and constraining

Berthier J., Clementz Ph., Jary D., Raccurt O., Claustre P., Peponnet C., Fouillet Y., CEA-LETI, FR

We present a novel contribution to the design of electrowetting microdevices (EWOD) by using an energy minimization approach. Altough the dynamics of motion of microdrops by electrowetting may be rapid, it is shown that, due [...]

An Analytical Model for the Prediction of Microdrop Extraction and Splitting in Digital Microfluidics Systems

Berthier J., Raccurt O., Clementz Ph., Jary D., Claustre P., Peponnet C., Fouillet Y., CEA-LETI, FR

In the preceding text submitted to Nanotech 2005, we have demonstrated that surface tension is the dominant force on liquid microdrops in EWOD microsystems and that the problem is mostly topological. Minimization of the surface [...]