Materials for Drug & Gene Delivery

An Enzyme-Responsive Controlled Release Drug Delivery System Based on Mesoporous Silica and DNA

Zhang X., Wu Z., Hefei Institutes of Physical Science, Chinese Academy of Sciences, CN

An efficient enzyme-responsive controlled release drug delivery system was fabricated using functional mesoporous silica nanoparticles (FMSN) encapsulated with the single-stranded DNA. Based on the electrostatic interactions between FMSN and single-stranded DNA, the DNA coating could [...]

Self-assembling peptide dimers with multifunctionalities for gene delivery systems

Ryu K., Lee G.J., Kim T.I., Seoul National University, KR

Peptides have been used in various biomedical fields including gene and drug delivery systems [1]. There are many peptide sequences which can interact with cellular molecules or components. These biological interactions of peptide represented many [...]

The characterization and reductive degradation behavior study of bioreducible crosslinked polypropylenimine dendrimers for gene delivery systems

Lee G.J., Ryu K., Kim T.I., Seoul National University, KR

Polypropylenimine (PPI) dendrimers and their derivatives have been used for gene delivery because of their properties such as cationic charge, equivalent surface functionalities, and internal cavities [1–4]. However, high generation PPIs made high cytotoxicity induced [...]

Folic Acid Conjugated Polymer as a New Active Tumor Targeting Drug Delivery Platform

Li X., Szewczuk M.R., Malardier-Jugroot C., Royal Military College of Canada, CA

Nanotechnology has been extensively exploited to improve conventional cancer therapy in the recent years1. The designed nanocarriers allow drug to be delivered to cancer cells specifically with prolonged circulation time and controlled drug release2–4. In [...]

Preparation of isoniazid-coupled gold and silver nano-systems: Investigation on antibiotic corona and metal core reliant biological events

Navya P.N., Daima H.K., Siddaganga Institute of Technology, IN

Innovative approaches to engineer nanoparticles with desired physicochemical characteristics open new opportunities to utilise such materials for assorted applications. In this context, various methods have been developed to prepare metal nanoparticles. However, most of the [...]

Translational Research of Hemoglobin-vesicles as a Transfusion Alternative

Sakai H., Nara Medical University, JP

A fluid of hemoglobin-vesicles, Hb-V, is being developed as a transfusion alternative that comprises concentrated particle dispersion ([Hb] = 10 g/dL, occupied particle volume = 40%, particle size = 250 nm) with physicochemical characteristics comparable [...]

Nanostructured lipid carriers as delivery systems of chemically grafted protein antigens

Bayon E., Morlieras J., Courant T., Gonon A., Marche P., Navarro F., CEA, FR

The development of vaccines was one of the major health advances of the last century. However, new vaccine formulations are still highly anticipated in the near future for facing some health challenges, such as the [...]

Nanodelivery of Cerebrolsyin in combination with neprilysin induces neuroprotection in Alzheimer’s Disease pathology following brain injury

Sharma A., Sharma H.S., Muresanu D.F., Lafuente J.V., Patnaik R., Tian Z.R., Ozikzilcik A., Mössler H., Sharma A., Sharma H.S., Uppsala University, SE

Neprilysin (NPL) is an endogenous enzyme that functions as rate-limiting step in amyloid-beta peptide (AβP) degradation. There are reasons to believe that an imbalance between production and clearance of AβP results in its accumulation leading [...]

Skin permeation of hydrophobic drugs loaded into polymeric nanoparticles

Feitosa V.A., Balogh T.S., Guimarães K.L., Zanin M.H.A., Oliveira A.M., Cerize N.N.P., Institute for Technological Research – IPT, BR

Polymeric nanoparticles have been employed for topical pharmaceutical applications due to its capacity to carry drugs across the skin. Biocompatible polymers are extensively applied as coating nanoparticles allowing them present controlled physical and chemical characteristics. [...]

Ferromagnetic Gd5Si4 Nanoparticles for Medical Applications

Forney C., Iowa State University, US

The Gd5(SixGe1-x)4 system has been widely studied in the bulk form, but synthesis of nanoparticles of the material have never been reported. Iowa State University researchers have developed a process to fabricate ferromagnetic submicrometer Gd5Si4 [...]

TiO2 Nanowired Cerebrolysin reduces neuron-specific ubiquitin carboxyl-terminal esterase-L1 (UCHL1) in Alzheimer’s Disease and brain pathology

Muresanu D.F., Sharma A., Sharma H.S., Lafuente J.V., Patnaik R., Tian Z.R., Ozikzilcik A., Mössler H., Sharma A., Sharma H.S., University of Medicine & Pharmacy, RO

Our military personnel during combat operations are vulnerable to various kinds of traumatic brain injuries. These soldiers are prone to develop neurodegenerative diseases e.g., Alzheimer’s Disease (AD) over time. Thus, efforts should be made to [...]

Nanodelivery of drugs for therapeutic strategies in CNS disorders. Current and Future perspectives

Sharma A., Sharma H.S., Muresanu D.F., Lafuente J.V., Patnaik R., Tian Z.R., Ozikzilcik A., Mössler H., Sharma A., Sharma H.S., Uppsala University, SE

Nanodelivery of drugs, diagnostic agents and other functionalized nanoparticles aiming for better treatment of diseases or diagnosis purposes are the new trends in medicine that appear promising. However, nanoparticles or nanotechnology used to deliver these [...]

Production of NSAID pharmaceutical molecular liquids via RESS processing

Kumar Sharma S., Woldetsadik A.D., Magzouband M., Jagannathan R., New York University Abu Dhabi, AE

Abstract One of the prominent challenges in pharmaceutical drug development is the poor aqueous solubility of many pharmaceutical drugs and subsequently, their reduced bioavailability. Traditional drug delivery strategies are not target specific in the body [...]

Novel method for topical and transdermal delivery of Nanomaterials

Kalghatgi S., Juluri A., Stone S., Gray R., EP Technologies LLC, US

Nanoscale drug delivery systems including, but not limited to nanoparticles, liposomes, nanotubes, quantum dots, could potentially revolutionize modern drug delivery systems. Nanomaterials have wide applications in pharmaceutical sciences including their use in drug delivery as [...]