Nanodelivery of Chinese traditional medicine extract of Gingko Biloba (EGb-761) induces superior neuroprotection following traumatic brain injury in heat stroke

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Military personnel are often exposed to high summer heat resulting in heat stroke (HS) and related illnesses. HS often results in serious mental and physical consequences due to breakdown of the blood-brain barrier (BBB) to [...]

TiO2 nanowired delivery of cerebrolysin induces superior neuroprotection following exacerbation of blast brain injury pathophysiology in diabetes

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Blast brain injury (bBI), a combination of pressure, rotation, penetration of sharp objects and chemical exposure is prevalent in military personnel during combat operations causing laceration, perforation and tissue loss in the brain. Since combat [...]

Intraspinal administration of TiO2 nanowired cerebrolysin with mesenchymal stem cells has superior neuroprotective effects on cord pathology and functional outcome following a focal spinal cord trauma

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Military personnel are often victims of spinal cord injury (SCI) for which there is no suitable treatment available. Thus, exploring new therapeutic avenues using select combination of novel neuroprotective agents is the need of the [...]

TiO2-nanowired delivery of cerebrolysin thwarts exacerbation of sleep deprivation induced decline in regional brain derived neurotrophic factor, brain pathology and behavioral dysfunctions following emotional stress

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Sleep deprivation (SD) is a serious problem in military personnel during combat operations. Normally they have only a few hours of sleep under severe stressful conditions. This leads to profound mental and cognitive dysfunctions. Previous [...]

Neuroprotective effects of cerebrolysin in exacerbation of blood-brain barrier breakdown, neuropathology and upregulation of nitric oxide synthase and hemeoxygenase in diabetes and hypertension after heat stroke

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Military personnel are often exposed to heat stress in desert areas either during peacekeeping or combat operations. In such situations, they are quite vulnerable to heat stroke and brain pathology. Due to severe work stress [...]

Nanodelivery of cerebrolysin reduces depressive stress induced exacerbation of Alzheimer’s disease brain pathology following amyloid-beta peptide infusion

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Military personnel are highly vulnerable to Alzheimer’s disease (AD). This is because of the fact that severe stress of trauma, sleep deprivation or combat stress causes increased deposition of amyloid beta peptide in the cerebrospinal [...]

Nanodelivery of cerebrolysin reduces functionalized Gold Nanoparticles induced Blood-brain barrier disruption, brain edema formation and brain pathology

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Recently, gold nanoparticles (AuNPs) are used for drug delivery in treating several neurological disorders e.g., Alzheimer’s disease (AD), Parkinson’s disease, Stroke and trauma. In addition, use of AuNPs for diagnostic purposes in various diseases are [...]

TiO2 Nanowired Cerebrolysin reduces neuron-specific ubiquitin carboxyl-terminal esterase-L1 (UCHL1) in Alzheimer’s Disease and brain pathology

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Our military personnel during combat operations are vulnerable to various kinds of traumatic brain injuries. These soldiers are prone to develop neurodegenerative diseases e.g., Alzheimer’s Disease (AD) over time. Thus, efforts should be made to [...]