Lee G.J. – TechConnect Briefs

The characterization and reductive degradation behavior study of bioreducible crosslinked polypropylenimine dendrimers for gene delivery systems

Lee G.J., Ryu K., Kim T.I., Seoul National University, KR

Polypropylenimine (PPI) dendrimers and their derivatives have been used for gene delivery because of their properties such as cationic charge, equivalent surface functionalities, and internal cavities [1–4]. However, high generation PPIs made high cytotoxicity induced [...]

Self-assembling peptide dimers with multifunctionalities for gene delivery systems

Ryu K., Lee G.J., Kim T.I., Seoul National University, KR

Peptides have been used in various biomedical fields including gene and drug delivery systems [1]. There are many peptide sequences which can interact with cellular molecules or components. These biological interactions of peptide represented many [...]

Nanostructural and biochemical property changes in activation-induced CD8+ T cell apoptosis utilizing AFM and Raman spectroscopy

Lee G.J., Lee Y.J., Lee G.J., Lee Y.J., Park H.K., Kyung Hee University, KR

This study was to investigate the changes in nanostructure and biochemical properties of activated mature CD8+ T cells related to apoptosis at a molecular level. We confirmed the activation and apoptosis of CD8+ T cells [...]

Simultaneous Measurement of Nitric Oxide and Oxygen Dynamics during Myocardial Ischemia Reperfusion of Rat

Lee G.J., Kang S-W, Kim O.K., Kim S.K., Kim O.K., Kim S.K., Shin J.-H., Park H.K., Kyung Hee University, KR

Myocardial function is dependent on a constant supply of oxygen from coronary circulation. Therefore the accurate measurement of oxygen concentration in postischemic myocardium is crucial to the assessment of myocardial viability and function. Nitric oxide [...]

Investigation of Taxol effects on morphological and micromechanical properties of human endometrial adenocarcinoma cells by AFM

Kim J.H., Kim K.S., Cho C.H., Choi Y.J., Kim J.H., Kim K.S., Choi Y.J., Jung G.B., Jung M-H, Yoon K-S, Woo Lee J., Lee G.J., Jung G.B., Jung M-H, Park H.K., Kyung Hee University, KR

The effects of Taxol on morphological and micromechanical properties of human endometrial adenocarcinoma (Ishikawa cell), were investigated by atomic force microscopy (AFM). The morphological and mechanical properties of the Ishikawa cell were significantly changed by [...]

Structural and Mechanical Changes in Heart Mitochondria of Rat by AFM

Lee G.J., Lee J.W., Chae S.-J., Kang S-W, Lee G.J., Lee J.W., Ha S.J., Kim W., Kim Y., Kim W., Kim Y., Park H.K., Kyung Hee University, KR

Mitochondria play critical roles in both the life and death of cardiac myocytes. Various factors such as loss of ATP synthesis and increase of ATP hydrolysis, impairment in ionic homeostasis, formation of reactive oxygen species [...]

Nanoscale structure and property changes in collagen fibrils on the extracorporeal shockwave therapy applications of the rat Achilles tendon injury

Choi S., Lee G.J., Chon J., Chae S.-J., Yoo S.-D., Park H.K., Park J.H., Kim K.S., Park H.K., Park J.H., Kyung Hee University, KR

Extracorporeal shockwave therapy (ESWT) is popular in the treatment of musculo-skeletal injuries. However, the mechanism by which such therapy might have an effect on tendon injury is unknown. The Achilles tendons are mainly composed of [...]

Measurement of Structural and Mechanical Property of Live Mesangial Cell (MC) by Atomic Force Microscopy (AFM)

Lee G.J., Lee S-H., Park E.J., Park H.K., Park J.H., Lee G.J., Lee S-H., Lim J.E., Eo Y.H., Han J.H., Choi S., Park E.J., Park H.K., Park J.H., Shin Y.A., Jin H.S., Hong K.W., Oh B.S., Park E.J., Park H.K., Park J.H., Kyung Hee University, KR

Atomic force microscopy (AFM) has become an important device to visualize various cells and biological materials for non-invasive imaging. The major advantage of AFM compared to the conventional optical and electron microscopes is its convenience. [...]

Real-time detection of neurotransmitter using enzyme-immobilized CNT network transistors in 11 vessel occlusion rat model

Lee G.J., Lim J.E., Park H.J., Park H.K., Park J.H., Eo Y.H., Kim B.S., Park H.J., Park H.K., Park J.H., Choi S.K., Hong S., Park H.J., Park H.K., Park J.H., Kyung Hee University, KR

The field effect transistor (FET) made of carbon nanotube (CNT) can be used as sensor due to their extreme sensitivity to local chemical environments. Glutamate is the principal excitatory neurotransmitter in the brain, and its [...]