Malardier-Jugroot C. – TechConnect Briefs

Folic Acid Conjugated Polymer as a New Active Tumor Targeting Drug Delivery Platform

Li X., Szewczuk M.R., Malardier-Jugroot C., Royal Military College of Canada, CA

Nanotechnology has been extensively exploited to improve conventional cancer therapy in the recent years1. The designed nanocarriers allow drug to be delivered to cancer cells specifically with prolonged circulation time and controlled drug release2–4. In [...]

Confinement Chemistry in Self-Assembling Polymer-Metal Nanoreactors

McTaggart M., Malardier-Jugroot C., Royal Military College of Canada, CA

We have developed and thoroughly characterized stable polymer-metal nanocomposite reactor systems with hydrophobic inner surfaces 2-3 nm apart. Previous work has shown that energetically unfavourable reactions, namely pyrrole polymerization and metal salt reduction, spontaneously occur [...]

Controlling the Active Center of Gold Nanoreactors by Mediating the Metal-Polymer Interaction

Shah V., Malardier-Jugroot C., Jugroot M., Malardier-Jugroot C., Royal Military College of Canada, CA

Nanomaterials have gained large interest from the scientific community due to the fact that materials at nanoscale exhibit unique electronic, magnetic and optical properties when compared to the bulk. The main advantage associated with nanostructures [...]

Synthesis of a pH Responsive Polymeric Drug Delivery – tailoring functionalization for effective delivery

Li X., Malardier-Jugroot C., Royal Military College of Canada, CA

Poly (styrene-alt-maleic anhydride), PSMA, is an amphiphilic alternating copolymer presenting a pH responsible self-assembly into nanotubes in aqueous solution. Its self-assembled structure with a 2nm hydrophobic inner diameter is stable in neutral pH solution, but [...]

Biomimetic Nanoreactors via in situ Synthesis of Atomically-Thin Gold Sheets and Platinum Nanoclusters

McTaggart M., Malardier-Jugroot C., Jugroot M., Malardier-Jugroot C., Royal Military College of Canada, CA

We present the synthesis and activity of broadly stable polymer-metal nanoreactors capable of confinement-enhanced catalysis. Poly(styrene-alt-maleic acid), SMA, is known to self-assemble in water into highly organized supramolecular nanostructures containing confined polar and non-polar reaction [...]

Synthesis and characterization of nanoreactors within polymeric nanotemplates

McTaggart M., Groves M., Malardier-Jugroot C., Jugroot M., Malardier-Jugroot C., Royal Military College of Canada, CA

The paper will present a novel method for the synthesis of metal nanoclusters with diameters < 3nm within an amphiphilic nanotube template without the use of a reducing agent. This environmentally friendly synthesis occurs at [...]

Molecular Hydrogen Storage in Fullerenes for Use on Board Fuel Cell Vehicles – A Density Functional Theory Study

Durbin D.J., Allan N.L., Malardier-Jugroot C., Royal Military College, CA

Hydrogen gas is a potential fuel to replace gasoline on board vehicles. However, viable storage methods must be developed. Carbon nanomaterials are promising because they are cheap, lightweight and abundant but carbon-hydrogen physisorption is weak [...]

Molecular Hydrogen Storage in Fullerenes for Use on Board Fuel Cell Vehicles – A Density Functional Theory Study

Durbin D.J., Allan N.L., Malardier-Jugroot C., Royal Military College, CA

Hydrogen gas is a potential fuel to replace gasoline on board vehicles. However, viable storage methods must be developed. Carbon nanomaterials are promising because they are cheap, lightweight and abundant but carbon-hydrogen physisorption is weak [...]

Simulation and synthesis of a self-assembling and tumor-targeted drug delivery system

McTaggart M., Li X., Malardier-Jugroot C., Royal Military College of Canada, CA

Poly(styrene-alt-maleic anhydride) is an amphiphilic alternating copolymer that self-assembles into supramolecular nanotubes in aqueous, physiological-pH environments. Its 2nm hydrophobic inner diameter is stable in neutral pH solution but opens as pH drops. Folate-conjugated nanotubes could [...]

Synthesis and characterization of nanoreactors within polymeric nanotemplates

McTaggart M., Groves M., Malardier-Jugroot C., Jugroot M., Malardier-Jugroot C., Royal Military College of Canada, CA

The paper will present a novel method for the synthesis of metal nanoclusters with diameters < 3nm within an amphiphilic nanotube template without the use of a reducing agent. This environmentally friendly synthesis occurs at [...]