Navarro F. – TechConnect Briefs

Companion diagnostic test using digital microfluidic

Fouillet Y., Den Dulk R., Fuchs O., Boizot F., Menneteau M., Navarro F., CEA-LETI, FR

Companion diagnostics are an indispensable part of personalized medicine, providing information that is essential for the safe and effective use of a corresponding therapeutic drug. Such devices need to be robust, transportable and easy to [...]

Bedaquiline loaded lipid nanoparticles: a promising candidate for TB treatment

Jary D., Hibbitts A., Lozano-Fernandez T., Pérez D., Lucia A., Ainsa J.A., Codony D., Freire C., Redinger N., Schaible U., Coya Raboso J.M., Tailleux L., Navarro F., CEA-LETI, FR

Increase in antibiotic resistance is a global concern worldwide[1], with 480,000 new cases of multi-drug resistant tuberculosis (MDR-TB) diagnosed each year. Therefore, the goals for the Nanotherapeutics for Antibiotic Resistant Emmerging Bacterial pathogens (NAREB) research [...]

Two-phase spontaneous capillary microflows and the transport of capillary wagons

Berthier E., Berthier J., Brakke K., Lee Jing, Gosselin D., Navarro F., Theberge A., Berthier E., Berthier J., CEA-LETI, FR

The use of capillarity to move fluids at the microscale has been soaring lately due to new applications in medicine, biology, biotechnology, energy, thermic and space. Especially of interest are open capillary channels. These channels [...]

On the use of Zisman’s function for the determination of the velocity of spontaneous capillary microflows

Berthier E., Berthier J., Lee Jing, Gosselin D., Navarro F., Berthier E., Berthier J., Theberge A., CEA-LETI, FR

Capillary-based microfluidic systems are increasingly used in the fields of biotechnology, medicine, thermics, energy and space. In such systems the energy source responsible for the flow is the surface energy of the walls. Extending the [...]

Low-cost screen printed and embossed LAMP micro-reactors

Gosselin D., Gougis M., Baque M., Maffini-Alvaro V., Mailley P., Bourdat A.G., Vignoud S., Navarro F., Belgacem M.N., Chaussy D., Berthier J., CEA-Grenoble, FR

Introduction: Diagnostic is probably the most important step in the fight against infectious diseases and epidemics. While it is necessary to give a treatment to diseased people, it is just as important to give the [...]

Deterministic Lateral Displacement (DLD): Finite element modeling and experimental validation for particle trajectory and separation

Pariset E., Berthier J., Révol-Cavalier F., Pudda C., Gosselin D., Navarro F., Icard B., Agache V., CEA-LETI, FR

In biotechnology and biology, deterministic lateral displacement (DLD) arrays are used to separate particles based on their size, such as cells, bacteria, parasites and exosomes. DLD is very promising for sample preparation purposes as it [...]

On the use of polymeric additives to promote plasma separation from whole blood in open microchannels

Lee E., Berthier J., Laurent P., Navarro F., Cubizolles M., CEA, FR

Polymers additives in whole blood are known to modify blood physical properties. For example, Dextran molecules usually accelerate the aggregation of re-suspended RBCs in Ringer solutions. In this work, we first investigate the effect of [...]

Nanostructured lipid carriers as delivery systems of chemically grafted protein antigens

Bayon E., Morlieras J., Courant T., Gonon A., Marche P., Navarro F., CEA, FR

The development of vaccines was one of the major health advances of the last century. However, new vaccine formulations are still highly anticipated in the near future for facing some health challenges, such as the [...]

Nanoemulsion with tuneable lipid shell dedicated to targeted delivery of small and biomacro- molecules

Couffin A.C., Bruniaux J., Courant T., Hoang A., Martin C., Fournier A., Mittler F., Texier I., Sulpice E., Auzély-Velty R., Gidrol X., Navarro F., Commissariat à l'Energie Atomique et aux Energies Alternatives, FR

Lipid nanocarriers are considered as suitable carriers to formulate lipophilic drugs, transport them and also deliver more specifically at appropriate biological sites. Based on oil-in-water template emulsion, we have been developing nanodroplets as drug or [...]

Lipid nanoparticles: tumor-targeting nanocargos for drug and contrast agent delivery

Delmas T., Navarro F., Gravier J., Thomann J.S., Heinrich E., Mérian J., Fraichard A., Boisgard R., Tavitian B., Dufort S., Coll J.L., Bibette J., Boisseau P., Couffin A.C., Texier I., CEA-Grenoble, FR

A new technology for the encapsulation of lipophilic molecules -both drugs and contrast agents dedicated to chemotherapy, phototherapy, or fluorescence imaging in oncology- has been developed, based on oil-in-water nanoemulsions. Thorough physico-chemical characterizations of the [...]