An Enzyme-Responsive Controlled Release Drug Delivery System Based on Mesoporous Silica and DNA


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An efficient enzyme-responsive controlled release drug delivery system was fabricated using functional mesoporous silica nanoparticles (FMSN) encapsulated with the single-stranded DNA. Based on the electrostatic interactions between FMSN and single-stranded DNA, the DNA coating could act as gates for storage of drugs. When DNase I enzyme was added, the DNA could be hydrolyzed to plenty of tiny fragments through the hydrolysis effect of DNase I, and obviously, the gates started to open and drugs loaded in the mesopores of MSN could be released. The system showed an excellent drug release performance, and was expected to be helpful to increase the treatment efficiency of drugs.

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Journal: TechConnect Briefs
Volume: 3, Biotech, Biomaterials and Biomedical: TechConnect Briefs 2016
Published: May 22, 2016
Pages: 51 - 52
Industry sectors: Advanced Materials & Manufacturing | Medical & Biotech
Topics: Biomaterials, Materials for Drug & Gene Delivery
ISBN: 978-0-9975-1172-7