Cancer Nanotechnology – TechConnect Briefs

Detection of Cancer Related DNA Nanoparticulate Biomarkers and Nanoparticles in Whole Blood

Heller M.J., Krishnan R., Sonnenberg A., University of California San Diego, US

The ability to rapidly detect DNA nanoparticulate biomarkers and drug delivery nanoparticles directly in blood is a major challenge for early disease detection and nanomedicine. We now show that a microarray dielectrophoretic (DEP) device can [...]

Combining gene therapy and nanomedicine to enhance the therapeutic potential of T cells

Choi Y., Torikai H., Lee D.A., Lee D.Y., Li K.C., Li Z., Lo D., Qin G., Tung C.H., Tasciotti E., Raphael R., Biswal S.L., Ang S., Lee D.A., Lee D.Y., Li K.C., Li Z., Cooper L.J.N., M.D. Anderson Cancer Center, US

we have developed a high throughput electroporator (HiTE) to manipulate large numbers (~10^9) of T cells ex vivo for clinical uses. HiTE is designed to electro-transfer RNA species to redirect T-cell specificity and gold nanoparticles [...]

Doxorubicin-loaded and Antibody-Conjugated Liposome-QD Hybrid Vesicles for Targeted Cancer Therapy and Imaging

Tian B.W., Al-Jamal W.T., Stuartb M., Kostarelos K., The School of Pharmacy, University of London, UK

In this study, we report the engineering of multimodal Liposome-QD hybrids (L-QD) for cancer imaging and therapy. L-QD hybrids were loaded with doxorubicin (Dox) using the osmotic gradient technique, achieving high encapsulation efficiency comparable to [...]

Targeting tumor associated macrophages using clodronate-loaded PLGA nanoparticles

Sharma G., Karmali P., Ramirez M., Xie Hui, Ruoslahti E., Smith J., Burnham Institute for Medical Research, US

There is increasing evidence now that tumor associated macrophages (TAMs) play a key role in tumor growth and metastasis by promoting tumor angiogenesis. Macrophages are also prominent in tumor tissues, comprising up to 80% of [...]

Bioluminescent Model for the Quantification of Photothermal Ablative Breast Cancer Therapy Mediated by Near-Infrared Nanoparticles

Gutwein L.G., Singh A.K., Hahn M.A., Rule M.C., Brown S.C., Moudgil B., Grobmyer S.R., University of Florida, US

Multifunctional nanoparticles hold promise for enabling non-invasive image guided cancer therapy such as photothermal therapy. Human breast tumor models in which response to image guided therapy can quickly and non-invasively be determined are needed to [...]

Visualization of Thyroid Cancer Signs by Atomic Force Microscopy

Reshetov I.V., Chissov V.I., Sukharev S.S., Slavnova E.N., Volchenco N.N., Bykov V.A., P.A.Hertzen Moscow Research Oncological Institute, RU

Aim: Search for the AFM signs of the thyroid cancer. Instruments and Materials: AFM-system NTEGRA Prima, NT-MDT Co., Zelenograd, Russia. Cytological specimens prepared identically to those used in traditional cytological studies. Characteristics measured: the heights [...]

Nanocarriers for Cancer Therapy

Vergaro V., Zheng X., Zheng Z., Zheng X., Zheng Z., Lvov Y.M., Giovinazzo G., Santino A., Cingolani R., Rinaldi R., Leporatti S., National Nanotechnology Laboratory (NNL) of CNR-INFM, IT

Drug nano-colloids encapsulated by combination of layer by layer (LbL) techniques and ultrasonication, phytochemical encapsulated-artificial oleosomes and drug-loading clay nanotubes have been uptaken by neoplastic cells. Morpho- mechanical changes induced by such nanocarriers in living [...]

Halloysite Clay Nanotubes: Characterization, Biocompatibility and Use as Drug Carriers

Vergaro V., Abdullayev E., Zeitoun A., Giovinazzo G., Santino A., Cingolani R., Lvov Y.M., Leporatti S., National Nanotechnology Laboratory (NNL) of CNR-INFM, IT

Halloysite nanotubes (HNTs) are efficient nano-containers capable of entrapping a range of active agents within the inner lumen, followed by their retention and slow release. Halloysite is a green environmentally friendly object available in commercial [...]

Minimal-dose cancer chemotherapy: Anti-cancer drugs loaded nanodevices towards time, site, and organ-specific releases for development of personalized nanomedicine

Khan R.A., Newati S.J., Singh V.M., Sachdeva S., Sharma R., Manav Rachna International University (MRIU), IN

The objective of the present study was to develop a site specific, time controlled and organ targeted anti-cancer drug delivery nanosystem comprising of nano-particles of polymeric origins for treatment of cancer in minimum dose regimen. [...]

Anti-K-Ras siRNA to Treat Pancreatic Cancer

Julien D.C., Giri A., Papasani M., Murdoch G., Hrdlicka P., Hill R.A., University of Idaho, US

Cancer of the pancreas is a leading cause of cancer-related mortality. Chemotherapeutic drugs used to treat pancreatic cancers are toxic and minimally effective, yielding a 1-4% 5-year survival rate after initial diagnosis. Approximately 90% of [...]

Multifunctional Fe3O4/ZnO core-shell nanoparticles for photodynamic therapy

Beltran J.C., Tomar M.S., Singh S.P., Perales O., Rivera L., Peña S., University of Puerto Rico-Mayagüez, PR

The photodynamic therapy (PDT) based on core-shell structures require efficient luminescence within specific wavelength range, preferably in near infrared. In the present study we aim to create a multifunctional platform for PDT through Fe3O4/ZnO core [...]

Multimodality therapy: Enhancement of melanoma cell death with combination of heat shock protein 90 inhibitor, 17-(Allylamino)-17-demethoxygeldanamycin (17-AAG), and gold nanoparticles in a noninvasive radiofrequency field

Kaluarachchi W.D., Curley S.A., M.D. Anderson Cancer Center, US

Melanoma is the most deadly form of skin cancer. Hyperthermia has been used to treat advanced stage melanoma. However, solid tumors often respond minimally to hyperthermic treatment due to the thermo-tolerance induced by chaperons of [...]

Zebrafish as a universal in vivo model for plasmonic nanoparticle medicine

Lukianova-Hleb E., Santiago C., Wagner D., Hafner J., Lapotko D., Rice University, US

In vivo application of plasmonic methods faces serious challenges because standard animal models are not well suited for optical activation and detection of plasmonic effects and for precise control the distribution and interactions of the [...]

Development of new thermo-ablation therapy using magnetic nanoparticles and device for alternating magnetic field

Hashimoto S., Oda T., Yamada K., Ohara Y., Ohkohchi N., Kanamori T., Ikehata Y., Nagano I., Yanagihara H., Kishimoto M., Kita E., University of Tsukuba, JP

Although induction heating cancer therapy (IHCT) using magnetic nanoparticles can be a promising approach to treatment-less multi-nodular cancers, combination of conventional super paramagnetic particle (SPIO) and standard alternating magnetic field (AMF) generator confer insufficient heat [...]

Nanomaterials Employed in Effective Tumor Treatment

Liang X-J., National Center for Nanoscience and Technology of China, CN

Chemotherapy is one of most effective cures to treat different of malignant tumors. Cisplatin is a chemotherapeutic compound commonly used in clinics, however, acquired resistance confines its application in chemotherapeutics. To overcome the acquired resistance [...]

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