Combining gene therapy and nanomedicine to enhance the therapeutic potential of T cells

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we have developed a high throughput electroporator (HiTE) to manipulate large numbers (~10^9) of T cells ex vivo for clinical uses. HiTE is designed to electro-transfer RNA species to redirect T-cell specificity and gold nanoparticles (Au-NPs) that can be functionalized to enhance T-cell biology. By introducing both transgenes and Au-NPs we are generating T cells that can be rapidly modified to act as a drug-delivery system for targeted therapy of lung cancer.

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Journal: TechConnect Briefs
Volume: 3, Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy
Published: June 21, 2010
Pages: 376 - 379
Industry sector: Medical & Biotech
Topics: Biomaterials, Cancer Nanotechnology
ISBN: 978-1-4398-3415-2