Multifunctional Fe3O4/ZnO core-shell nanoparticles for photodynamic therapy

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The photodynamic therapy (PDT) based on core-shell structures require efficient luminescence within specific wavelength range, preferably in near infrared. In the present study we aim to create a multifunctional platform for PDT through Fe3O4/ZnO core shell structure. The magnetic properties of these nanostructures will enable us magnetically driven tumor targeting as well delivery of photosensitizer. On the other hand, ZnO is well known for reactive oxygen species (ROS) generation and will help to kill cancer cells through oxidative stress. Fe3O4/ZnO core-shell nanostructures are synthesized via a simple aqueous solution method and characterized using X-ray diffraction (XRD, Vibrating sample magnetometer (VSM), Electron Diffraction Spectroscopy (EDS), Photoluminescence (PL) measurements. The results on capability of generating active singlet oxygen are in progress and will be presented.

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Journal: TechConnect Briefs
Volume: 3, Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy
Published: June 21, 2010
Pages: 405 - 408
Industry sector: Medical & Biotech
Topics: Biomaterials, Cancer Nanotechnology
ISBN: 978-1-4398-3415-2