Papers:
Novel Nanoprobes to Detect mRNA in situ Directed Against Mouse Pyruvate Dehydrogenas
Cheguru P., Østergaard M., Papasani M.R., Sai V.V.R., Wengel J., Hrdlicka P.J., Hill R.A., University of Idaho, US
Novel nanoscale synthetic locked nucleic acid (LNA) probes incorporating molecular beacon (MB) technology were developed. These novel MBs contained 2’-N-(pyren-1-yl)carbonyl-2’-amino-LNA monomers incorporated in the loop region. Specificity and sensitivity of MB designed to target the [...]
Role of Serum Proteins in the Cellular Uptake of Gold-Peptide Nanoconjugates
Gold nanoparticles (Au NPs) have been widely investigated as promising nanocarriers for therapeutics and other biologically active molecules. In the present study, two different cysteine-terminated peptides were used to form nanoconjugates with Au NPs (20 [...]
Formation of Drug Nanoparticles from Microemulsions
A new method for preparation of water-insoluble organic nanoparticles, in a form of re-dispersible powder will be described. The method is based on rapid conversion of nanodroplets into nanoparticles, by evaporation of all volatile solvents [...]
Water Soluble Carotenoid Conjugates with Oligo- and Polysaccharides. Synergy of Drug Transport and Efficacy
Polyakov N.E., Leshina T.V., Meteleva E.S., Dushkin A.V., Konovalova T.A., Kispert L.D., University of Alabama, US
We present first example of water soluble conjugates of carotenoids with a triterpene glycoside, glycyrrhizic acid (GA), and natural polysaccharide arabinogalactan (AG), studied by various physicochemical techniques. Carotenoids are well known as a class of [...]
Delivery of Camptothecin to Cancer Cells with Silica Nanoparticles
Botella P., Abasolo I., Muniesa C., Ruiz J., Fernández Y., Quesada M., Corma A., Schwartz Jr. S., Instituto de Tecnologia Quimica (UPV-CSIC), ES
We present a novel and robust delivery platform for camptothecin (CPT) based in silica nanoparticles (SNP) of 5-15 nm diameter that transport the drug attached by ester bond in 20-OH position. The surface of these [...]
Novel mesoporous silicon particles as an efficient sustained delivery system for antibiotics
Yazdi I., Chiappini C., Weiner B., Ferrari M., Tasciotti E., The University of Texas Health Science Center at Houston, US
Delivery systems able to release antibiotics over an extended period of time can solve all these issues and provide efficacious alternative solutions to the current approaches. The ultimate objective of this study is to prove [...]
Proteoliposome for Tumor-Targeting by Postinsertion of BAM-Homing Molecule Complex
Proteoliposome for Tumor-Targeting by Postinsertion of BAM-Homing Molecule Complex S. Y. Hwang, H. K. Kim, and E. K. Lee Department of Chemical Engineering, Hanyang University, Ansan, Korea and College of Bionanotechnology, Kyungwon University, Seongnam, Korea [...]
AS1411 aptamer-conjugated polymeric micelle for targetable cancer therapy
Targetable drug delivery system is a promising tool for cancer treatments. Herein we report a novel strategy of using G-quadruplex AS1411 aptamer-conjugated polyethylene-polylactide formed polymeric micelles (apt-PEG-PLA-PM) as a drug carrier to target cancer cells [...]
Synthesis and characterization of methoxy poly(ethylene glycol)-O-chitosan-polyethylenimine as a noviral carrier for gene delivery and expression
Yu Y.Y., Wang G., Wang Z., Cai L., Wang G., Wang Z., Yang X., Xu X.H., Xu Z.G., Wan X.P., Wang G., Wang Z., Xu X.H., Xu Z.G., Li Y., Jiang Q., Gao R., Sichuan University, CN
A novel water-soluble chitosan (CS) derivative，methoxy poly(ethylene glycol)-O-chitosan- polyethylenimine(mPEG-O-CS-PEI), was synthesized by grafting polycationic polyethylenimine (PEI) and methoxy poly (ethylene glycol) (mPEG) onto chitosan, the copolymer was characterized and confirmed by 1H-NMR and FT-IR spectra. [...]
Novel nanostructured drug delivery technology to enhance bioavailability, increase solubility and drug loading
In the presentation we will discuss the perspectives and pharmacokinetic benefits of the nanosized active molecules over the parent active molecules. The bioavailability of reference and nanosized drug was determined after oral administration (30 mg/kg) [...]
Stability of oligodeoxynucleotide complexes with cationic phospholipid and peptide carriers
Tenchov B., Koynova R., Ahn R., O’Halloran T., MacDonald R.C., Ohio State University College of Pharmacy, US
The use of cationic lipid and peptide compounds as carriers for the intracellular delivery of oligodeoxynucleotides (ODNs) with important regulatory functions is of high current interest. Here we used X-ray diffraction, fluorescence resonance energy transfer, [...]
A “leukolike” multistage delivery system to overcome biological barriers
Qauttrocchi N., Chiappini C., Cooper L., Ferrari M., Tasciotti E., University of Texas Health Science Center, US
Delivery systems based on Nanoporous Silicon Particles (NSPs) have been proposed as ideal candidates for the targeted release of drug and contrast agents to tumor sites as porous silicon is biocompatible, biodegradable and easy to [...]
Modified glycol chitosan nanocarriers carry hydrophobic materials into tumours
Raza A., de-la Fuente M., Uchegbu I.F., Schätzlein A., Nuclear Medicines Oncology & Radiotherapy Institute, PK
Etoposide is a potent anticancer drug commonly used in a variety of malignancies. High protein binding, requirement of fairly high doses of drugs to achieve sustained plasma levels and hypersensitivty issues are related to its [...]
The effect of Simvastatin Acid Loaded Photocurable Hyaluronic Acid Hydrogel for Bone Regeneration In vitro and In vivo
In the field of bone tissue engineering, various biomaterials have been developed in conjugation with bone inducing factors for bone tissue regeneration due to their distinct activities of osteoconductivity and osteoinductivity. In this study, we [...]
Transformation of gold nanoparticles into effective gene silencing vectors by oligoethylene glycol passivation
Small interfering RNAs (siRNAs) are useful agents for gene knockdown. We have taken a systematic approach to investigate the use of GNP as delivery platforms for firefly luciferase (FFL) siRNAs and the effect of passivation [...]
An Intracranial Neurocompatible Nanocomposite Polymeric Device for the Chronic Management of AIDS Dementia Complex
Khan R.A., Harilall S-L., Pillay V., Choonara Y.E., du Toit L.C., Modi G., Naidoo D., Iyuke S., Integral University, IN
This study focused on the design, biometric simulation and development of a biodegradable Composite Intracranial Nano-enabled Device (CIND) for the intracranial delivery of zidovudine (AZT) in the treatment of AIDS Dementia Complex (ADC), a common [...]
A proof of concept: a model of targeted stealth nanoparticles that are stable and biocompatible for RNA interference in vivo to macrophages
Bringing together advances generated through the developing fields of bionanotechnology and gene therapy, and demonstrated through the ABCD model, we propose a biocompatible, stable, specific stealth lipoplex targeting macrophages, as proof of concept, which is [...]
Sensitivity of Detection by Biological AFM for Gold-Labeled Liposomes at Human Coronary Artery Endothelial Cell (HCAEC) Membranes
Zaske A.M., Danila D., Queen M.C., Golunski E., Conyers J.L., University of Texas Health Science Center at Houston, US
Engineering of non-toxic nanoparticles for tissue-specific targeting has gained widespread attention this decade. Liposomes were one of the earliest classes of engineered nanoparticles to be utilized for the purpose of delivering drugs within the human [...]
Journal: TechConnect Briefs
Volume: 3, Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy
Published: June 21, 2010
Industry sector: Medical & Biotech
Topics: Biomaterials, Materials for Drug & Gene Delivery
ISBN: 978-1-4398-3415-2