Nanocarriers for Cancer Therapy

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Drug nano-colloids encapsulated by combination of layer by layer (LbL) techniques and ultrasonication, phytochemical encapsulated-artificial oleosomes and drug-loading clay nanotubes have been uptaken by neoplastic cells. Morpho- mechanical changes induced by such nanocarriers in living cancer cells have been detected by a combination of high resolution optical and scanning force microscopy techniques.Elasticity, which is considered a relevant marker of vitality and neoplastic invasiveness of cancer cells, has been quantified by Force Mapping Mode.The Young’s modulus of living treated cells is significantly modified in a time- and drug- carrier concentration-dependent manner as a consequence of modifications in cytoskeletal and contractile filament organization observed by selective fluorescent stainings.

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Journal: TechConnect Briefs
Volume: 3, Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy
Published: June 21, 2010
Pages: 393 - 394
Industry sector: Medical & Biotech
Topics: Biomaterials, Cancer Nanotechnology
ISBN: 978-1-4398-3415-2