Papers – Page 13 – TechConnect Briefs

Folic Acid Conjugated Polymer as a New Active Tumor Targeting Drug Delivery Platform

Li X., Szewczuk M.R., Malardier-Jugroot C., Royal Military College of Canada, CA

Nanotechnology has been extensively exploited to improve conventional cancer therapy in the recent years1. The designed nanocarriers allow drug to be delivered to cancer cells specifically with prolonged circulation time and controlled drug release2–4. In [...]

The characterization and reductive degradation behavior study of bioreducible crosslinked polypropylenimine dendrimers for gene delivery systems

Lee G.J., Ryu K., Kim T.I., Seoul National University, KR

Polypropylenimine (PPI) dendrimers and their derivatives have been used for gene delivery because of their properties such as cationic charge, equivalent surface functionalities, and internal cavities [1–4]. However, high generation PPIs made high cytotoxicity induced [...]

Self-assembling peptide dimers with multifunctionalities for gene delivery systems

Ryu K., Lee G.J., Kim T.I., Seoul National University, KR

Peptides have been used in various biomedical fields including gene and drug delivery systems [1]. There are many peptide sequences which can interact with cellular molecules or components. These biological interactions of peptide represented many [...]

An Enzyme-Responsive Controlled Release Drug Delivery System Based on Mesoporous Silica and DNA

Zhang X., Wu Z., Hefei Institutes of Physical Science, Chinese Academy of Sciences, CN

An efficient enzyme-responsive controlled release drug delivery system was fabricated using functional mesoporous silica nanoparticles (FMSN) encapsulated with the single-stranded DNA. Based on the electrostatic interactions between FMSN and single-stranded DNA, the DNA coating could [...]

In vitro reduction of mycotoxins and other inflammatory mediators from whole blood using CytoSorb® hemoadsorbent polymer beads

Scheirer A.R., Rueggeberg K.-G., Golobish T.D., Guliashvili T., Gruda M.C., O’Sullivan P., Chan P.P., CytoSorbents Corporation, US

Opportunistic fungal infections account for up to 25% of all hospital-acquired blood infections. Patients at highest risk are those with weakened immune systems, and include elderly patients, patients with cancer or HIV infection, and patients [...]

Comparing Biocompatibility of Titanium Orthopaedic Implants With and Without an Ultra-thin Coating of TiO2 by Ion Beam Assisted Deposition

Miralami R., Namavar F., Thiele G.M., Sharp J.G., Garvin K.L., University of Nebraska Medical Center, US

Introduction: Annually, more than one million Americans undergo arthroplastic surgeries, and by 2030 the projected number will exceed more than four million [1]. Thus, there is a serious need to accommodate such overload. It has [...]

A synergistic approach to the design, fabrication and evaluation of 3D printed micro and nano featured scaffolds for vascularized bone tissue repair

Holmes B., Bulusu K., Plesniak M., Zhang L.G., Nanochon LLC, George Washington University, US

In recent years, 3D printing has become a popular and widely investigated method for the fabrication of large bone implants. 3D printed bone constructs, devices and treatments hold great potential to repair traumatic and chronic [...]

Stable Magnetic Isotopes as New Trend in Nanonuclear Biotechnology

Koltover V., Institute of Problems of Chemical Physics, Russian Academy of Sciences, RU

With dimensions of the order of tens angstroms, biomolecular devices are assigned, in modern terminology, to objects of “nanophysics”. At the same time, all of them are composed from chemical elements many of which have [...]

Strategies for production of naturally-derived calcium phosphates particles for solid free-form fabrication

Miculescu F., Miculescu M., Maidaniuc A., Voicu S.I., Miculescu F., Miculescu M., Batalu D., University Politehnica from Bucharest, RO

In this abstract we propose the strategies optimization for obtaining ceramic materials derived from natural sources for solid free-form fabrication, used for bone substitution. The selected method, thermal processing, is simple (due to the similarities [...]

Biofilm as a versatile stablizer and promoter for Pd nanoparticle (PdNP) recovery and catalytic denitrification

Zhou C., Rittmann B.E., Wang Z., Ontiveros-Valencia A., Krajmalnik-Brown R., Arizona State University, US

There is an increasing demand on recycling of palladium from mining waste streams for purposes of resource retrieval and catalytic application. We introduced the novel H2-based membrane biofilm reactor (MBfR) technology to recover Pd in [...]