Papers – Page 25 – TechConnect Briefs

Sensitivity of Detection by Biological AFM for Gold-Labeled Liposomes at Human Coronary Artery Endothelial Cell (HCAEC) Membranes

Zaske A.M., Danila D., Queen M.C., Golunski E., Conyers J.L., University of Texas Health Science Center at Houston, US

Engineering of non-toxic nanoparticles for tissue-specific targeting has gained widespread attention this decade. Liposomes were one of the earliest classes of engineered nanoparticles to be utilized for the purpose of delivering drugs within the human [...]

A proof of concept: a model of targeted stealth nanoparticles that are stable and biocompatible for RNA interference in vivo to macrophages

Yusuf M.S., Miller A.D., Prata C.H., Imperial College Gene Therapies Centre, UK

Bringing together advances generated through the developing fields of bionanotechnology and gene therapy, and demonstrated through the ABCD model, we propose a biocompatible, stable, specific stealth lipoplex targeting macrophages, as proof of concept, which is [...]

An Intracranial Neurocompatible Nanocomposite Polymeric Device for the Chronic Management of AIDS Dementia Complex

Khan R.A., Harilall S-L., Pillay V., Choonara Y.E., du Toit L.C., Modi G., Naidoo D., Iyuke S., Integral University, IN

This study focused on the design, biometric simulation and development of a biodegradable Composite Intracranial Nano-enabled Device (CIND) for the intracranial delivery of zidovudine (AZT) in the treatment of AIDS Dementia Complex (ADC), a common [...]

Transformation of gold nanoparticles into effective gene silencing vectors by oligoethylene glycol passivation

Papasani M.R., Pokharel D., Giri A., Sai V.V.R., Hrdlicka P.J., Hill R.A., University of Idaho, US

Small interfering RNAs (siRNAs) are useful agents for gene knockdown. We have taken a systematic approach to investigate the use of GNP as delivery platforms for firefly luciferase (FFL) siRNAs and the effect of passivation [...]

The effect of Simvastatin Acid Loaded Photocurable Hyaluronic Acid Hydrogel for Bone Regeneration In vitro and In vivo

Bae M.S., Kim S.E., Na J.S., Kwon I.K., School of Dentistry, Kyung Hee University, KR

In the field of bone tissue engineering, various biomaterials have been developed in conjugation with bone inducing factors for bone tissue regeneration due to their distinct activities of osteoconductivity and osteoinductivity. In this study, we [...]

Modified glycol chitosan nanocarriers carry hydrophobic materials into tumours

Raza A., de-la Fuente M., Uchegbu I.F., Schätzlein A., Nuclear Medicines Oncology & Radiotherapy Institute, PK

Etoposide is a potent anticancer drug commonly used in a variety of malignancies. High protein binding, requirement of fairly high doses of drugs to achieve sustained plasma levels and hypersensitivty issues are related to its [...]

A “leukolike” multistage delivery system to overcome biological barriers

Qauttrocchi N., Chiappini C., Cooper L., Ferrari M., Tasciotti E., University of Texas Health Science Center, US

Delivery systems based on Nanoporous Silicon Particles (NSPs) have been proposed as ideal candidates for the targeted release of drug and contrast agents to tumor sites as porous silicon is biocompatible, biodegradable and easy to [...]

Stability of oligodeoxynucleotide complexes with cationic phospholipid and peptide carriers

Tenchov B., Koynova R., Ahn R., O’Halloran T., MacDonald R.C., Ohio State University College of Pharmacy, US

The use of cationic lipid and peptide compounds as carriers for the intracellular delivery of oligodeoxynucleotides (ODNs) with important regulatory functions is of high current interest. Here we used X-ray diffraction, fluorescence resonance energy transfer, [...]

Novel nanostructured drug delivery technology to enhance bioavailability, increase solubility and drug loading

Heltovics G., Ötvös Zs., Filipcsei G., Darvas F., NanGenex Inc., HU

In the presentation we will discuss the perspectives and pharmacokinetic benefits of the nanosized active molecules over the parent active molecules. The bioavailability of reference and nanosized drug was determined after oral administration (30 mg/kg) [...]

Synthesis and characterization of methoxy poly(ethylene glycol)-O-chitosan-polyethylenimine as a noviral carrier for gene delivery and expression

Yu Y.Y., Wang G., Wang Z., Cai L., Wang G., Wang Z., Yang X., Xu X.H., Xu Z.G., Wan X.P., Wang G., Wang Z., Xu X.H., Xu Z.G., Li Y., Jiang Q., Gao R., Sichuan University, CN

A novel water-soluble chitosan (CS) derivative，methoxy poly(ethylene glycol)-O-chitosan- polyethylenimine(mPEG-O-CS-PEI), was synthesized by grafting polycationic polyethylenimine (PEI) and methoxy poly (ethylene glycol) (mPEG) onto chitosan, the copolymer was characterized and confirmed by 1H-NMR and FT-IR spectra. [...]