Efficiency of different chitosan and its derivative nanoparticles for delivery of recombinant plasmid of Tibetan pig interleukin-7 gene and regulation effect in vivo on immune responses of mice

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For sake of developing safe and effective technique to deliver and express animal immune gene in vivo to enhance comprehensive immunity of animal against infectious disease, the interleukin-7 gene of Tibetan pig was firstly cloned [...]

Synthesis and characterization of methoxy poly(ethylene glycol)-O-chitosan-polyethylenimine as a noviral carrier for gene delivery and expression

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A novel water-soluble chitosan (CS) derivative,methoxy poly(ethylene glycol)-O-chitosan- polyethylenimine(mPEG-O-CS-PEI), was synthesized by grafting polycationic polyethylenimine (PEI) and methoxy poly (ethylene glycol) (mPEG) onto chitosan, the copolymer was characterized and confirmed by 1H-NMR and FT-IR spectra. [...]