Khan R.A., Harilall S-L., Pillay V., Choonara Y.E., du Toit L.C., Modi G., Naidoo D., Iyuke S.
Integral University, IN
Keywords: AIDS dementia complex, intracranial delivery, neurocompatible, polymeric nano composite
This study focused on the design, biometric simulation and development of a biodegradable Composite Intracranial Nano-enabled Device (CIND) for the intracranial delivery of zidovudine (AZT) in the treatment of AIDS Dementia Complex (ADC), a common CNS complication of late HIV-1 infection. AZT monotherapy administered orally is the gold standard in managing ADC but has limited bioavailability and significant side-effects. Due to the restrictive Blood-Brain Barrier nanoparticles can be used to penetrate the BBB and provide intracranial drug delivery. The CIND was modulated through biometric simulation and computational prototyping to produce a stable ternary crosslinked scaffold fixated with AZT-loaded alginate (ALG) nanoparticles.
Journal: TechConnect Briefs
Volume: 3, Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy
Published: June 21, 2010
Pages: 361 - 363
Industry sector: Medical & Biotech
Topics: Biomaterials, Materials for Drug & Gene Delivery