Papers – Page 26 – TechConnect Briefs

AS1411 aptamer-conjugated polymeric micelle for targetable cancer therapy

Lai P.S., Pai C.L., Hsu C.Y., National Chung Hsing University, TW

Targetable drug delivery system is a promising tool for cancer treatments. Herein we report a novel strategy of using G-quadruplex AS1411 aptamer-conjugated polyethylene-polylactide formed polymeric micelles (apt-PEG-PLA-PM) as a drug carrier to target cancer cells [...]

Proteoliposome for Tumor-Targeting by Postinsertion of BAM-Homing Molecule Complex

Hwang S.Y., Kim H.K., Lee E.K., Kyungwon University, KR

Proteoliposome for Tumor-Targeting by Postinsertion of BAM-Homing Molecule Complex S. Y. Hwang, H. K. Kim, and E. K. Lee Department of Chemical Engineering, Hanyang University, Ansan, Korea and College of Bionanotechnology, Kyungwon University, Seongnam, Korea [...]

Novel mesoporous silicon particles as an efficient sustained delivery system for antibiotics

Yazdi I., Chiappini C., Weiner B., Ferrari M., Tasciotti E., The University of Texas Health Science Center at Houston, US

Delivery systems able to release antibiotics over an extended period of time can solve all these issues and provide efficacious alternative solutions to the current approaches. The ultimate objective of this study is to prove [...]

Delivery of Camptothecin to Cancer Cells with Silica Nanoparticles

Botella P., Abasolo I., Muniesa C., Ruiz J., Fernández Y., Quesada M., Corma A., Schwartz Jr. S., Instituto de Tecnologia Quimica (UPV-CSIC), ES

We present a novel and robust delivery platform for camptothecin (CPT) based in silica nanoparticles (SNP) of 5-15 nm diameter that transport the drug attached by ester bond in 20-OH position. The surface of these [...]

Enhanced Cytotoxicity of Doxorubicin Conjugated to Ultrasmall Au Nanoparticles

Zhang E., Ntumba K., Nadeau J., McGill University, CA

In this study we find that ultra-small (mean diameter, 2.8 nm) Au nanoparticles conjugated to doxorubicin (Au-Dox) are up to five-fold more cytotoxic to B16 melanoma cells than Dox alone. The particles enter the cell [...]

Water Soluble Carotenoid Conjugates with Oligo- and Polysaccharides. Synergy of Drug Transport and Efficacy

Polyakov N.E., Leshina T.V., Meteleva E.S., Dushkin A.V., Konovalova T.A., Kispert L.D., University of Alabama, US

We present first example of water soluble conjugates of carotenoids with a triterpene glycoside, glycyrrhizic acid (GA), and natural polysaccharide arabinogalactan (AG), studied by various physicochemical techniques. Carotenoids are well known as a class of [...]

Formation of Drug Nanoparticles from Microemulsions

Magdassi S., Margulis-Goshen K., Hebrew University of Jerusalem, IL

A new method for preparation of water-insoluble organic nanoparticles, in a form of re-dispersible powder will be described. The method is based on rapid conversion of nanodroplets into nanoparticles, by evaporation of all volatile solvents [...]

Role of Serum Proteins in the Cellular Uptake of Gold-Peptide Nanoconjugates

Wang G., Papasani M.R., Hrdlicka P.J., Hill R.A., University of Idaho, US

Gold nanoparticles (Au NPs) have been widely investigated as promising nanocarriers for therapeutics and other biologically active molecules. In the present study, two different cysteine-terminated peptides were used to form nanoconjugates with Au NPs (20 [...]

Novel Nanoprobes to Detect mRNA in situ Directed Against Mouse Pyruvate Dehydrogenas

Cheguru P., Østergaard M., Papasani M.R., Sai V.V.R., Wengel J., Hrdlicka P.J., Hill R.A., University of Idaho, US

Novel nanoscale synthetic locked nucleic acid (LNA) probes incorporating molecular beacon (MB) technology were developed. These novel MBs contained 2’-N-(pyren-1-yl)carbonyl-2’-amino-LNA monomers incorporated in the loop region. Specificity and sensitivity of MB designed to target the [...]

Preparation of Novel Ferrocene-based Shell Cross-linked Thermoresponsive Hybrid Micelles with Anti-tumor Efficacy

Wei H., Dehghani F., The University of Sydney, AU

Shell cross-linked (SCL) thermoresponsive hybrid micelle consisting of a cross-linked thermoresponsive hybrid shell and a hydrophobic core domain was synthesized from poly(N-isopropylacrylamide-co-aminoethyl methacrylate)-b-polymethyl methacrylate (P(NIPAAm-co-AMA)-b-PMMA) amphiphilic block copolymers via a two-step process: micellization of P(NIPAAm-co-AMA)-b-PMMA [...]