Ostroff G. – TechConnect Briefs

Yeast Cell Wall Particle Encapsulation of Pro-Terpene Payloads

Soto E., Rus F., Ostroff G., University of Massachusetts Medical School, US

Terpenes are naturally occurring compounds produced by plants that have long been recognized for their insecticidal, antimicrobial, and antioxidant properties. However, applications of terpenes have been limited by their volatility and poor water solubility resulting [...]

Oral Delivery of Map4K4 siRNA to Macrophages Inhibits TNF alpha Production and Protects against a LPS-Galactosamine Challenge in Mice

Aouadi M., Tesz G., Soto E., Wang M., Nicoloro S., Ostroff G., Czech M., University of Massachusetts Medical School, US

RNA interference (RNAi) is a new, promising approach to selectively regulate gene expression through modulating mRNA stability and translation. However, the efficient delivery of 21 mer dsRNA molecules (siRNA) to affect RNAi remains a challenge. [...]

Oral Macrophage Mediated Gene Delivery System

Soto E., Ostroff G., University of Massachusetts Medical School, US

The efficiency of non-viral gene delivery is dependent on 4 factors: DNA protection, DNA delivery across membranes, endosomal DNA release, and nuclear uptake. Here we report on the development of a new delivery technology based [...]