Pompe disease in an autosomal recessive inherited condition characterised by deficiency of the enzyme acid -glucosidase. This causes accumulation of glycogen in muscles, significantly in the heart. The affect is a progressive muscle dysfunction, leading [...]
The study of the 3D architecture of cortex requires the creation of image datasets with sufficient detail in all directions. The detail level required to produce meaningful data requires imaging quality that allows identification of [...]
A superconducting field-effect transistor (SuFET) based neurotransducer (sensor) with carbon nanotubes (CNT) or pickup coil kind of input circuit for the nerve and neuron impulse has been designed. Electronic or ionic currents in conductors or [...]
The Allen Brain Atlas1 is the first large scale atlas of gene expression in the mouse brain, using chromogenic in situ hybridization (cISH) of over 20,000 genes.Qdots have excellent potential for muliplex imaging of gene [...]
The myelin sheath is among nature’s most fascinating nanoscale assemblies. In spite of its critical role in physiology, several questions on the structure-function relationship of myelin and its components remain unanswered. This is chiefly due [...]
Local delivery of therapeutic drugs will increase drug concentration at the site of treatment for maximum efficacy, and reduce systemic drug exposure. The encouraging results obtain in first phase of the clinical study of doxorubicin [...]
We set up different synthetic approaches to afford new different nanostructures cyclodextrin – low molecular weigh heparin (LMWH) characterized by covalent bonds (amine or amide) between -cyclodextrin and LMWH in different positions of the heparin [...]
Purpose: The objective of this study was to exam any difference after treatment of nanoparticle in cellular proliferation and gene expression in various cell types. Particularly, it was compared between the colloidal silver nanoparticle and [...]
, Cai D.
, Chiles T.C.
, Dufort F.J.
, Gumina M.R.
, Hong G.
, Huang Z.
, Kempa K.
, Ren Z.F.
, Boston College, US
Magnetic CNT can be driven into cells because it has an embedded Ni nanoparticle in its tip. We show herein that CNT-cell complexes are formed in the presence of a magnetic field. The complexes were [...]
To investigate molecular consequence of magnetic field to C. elegans, Fe3O4 nanoparticles were incorporated into the culture media of C. elegans and the nematodes were grown under magnetic field for 4 days. For the expermental [...]
Ionic gold (Au) compounds have been used for many years in the treatment of rheumatoid arthritis (aurotherapy). Despite their long history, the basis for their therapeutic properties has never been established definitively. We have observed [...]
One of the emerging goals of nanotechnology is to functionalize inert materials to impart precise biological functions resulting in biocompatible nano-platforms. The exploration of the interaction between nanostructured materials and living systems is of fundamental [...]
Carbon nanotube (CNT) development for biomedical applications is in the nascent stages, however is thought to lead to novel types of diagnostic, therapeutic and regenerative nanomedicines. The construction of CNT-based delivery systems able to traffick [...]
Multifunctional polymeric nanoparticles with an average size of 200nm could be prepared using the solvent displacement technique. Cetyltriethylammonium bromide (CTAB) surface-modified poly(ethylene oxide)-modified poly(epsilon-caprolactone) (PEO-PCL) nanoparticles encapsulated PTX and siRNA with a loading efficiency > [...]
The development of carbon nanomaterials for biomedical applications appears highly attractive due to their nanoscale properties although their biological profile is still in doubt. Herewith, we report that the amorphous vs crystalline character of carbon [...]
Pharmaceutical agents are often required to stimulate new bone formation for the treatment of bone injuries or diseases (such as osteoporosis and osteosarcoma). However, there are several problems associated with current drug delivery methods. First, [...]
We previously demonstrated that gadolinium endohedral metallofullerenol ([Gd@C82(OH)22]n nanoparticles) had high inhibitory activity on growth of malignant tumor in vivo by uncertain mechanism(s). The activities of enzymes associated with the metabolism of reactive oxygen species [...]
The main objective of the study was to design a non-condensing polymer microsphere-based gene delivery system for macrophages. An external gelation technique was used to prepare plasmid DNA-encapsulated calcium alginate microspheres. The microspheres were characterized [...]
Purpose: The objective of this study was to exam the therapeutic effects of silver nanoparticle on the inflammatory disease of the temporomandibular joint in the animal model. Materials and Method: Mustard oil was injected to [...]
Conventional fluorescent labels are of limited in vivo utility because short-wavelength radiation penetrates tissues poorly and excites strong background autofluorescence. Upconversion nanoparticles (UCN) convert low-energy exciting photons to visible emissions, resulting in deep tissue penetration [...]
In nature, metal oxide particles display their existance at the level of picomolecules in solution state and bioactive states in the body. We put evidence of picomolar behavior of molecules different than nanomolar behavior of [...]
Respiratory Syncytial Virus is the leading cause of severe respiratory illnesses such as bronchiolitis and pneumonia in young children. RSV is a paramyxovirus with negative-sense genomic RNA that encodes for eleven proteins, two of which, [...]
Poly(amidoamine) (PAMAM) based dendrimers are a class of organic particulate nanomaterials with great promise for improvement in cancer imaging and therapy. In this study, we systematically modify terminal groups of the parent generation 5 primary [...]
Composite nanodevices, with PAMAM dendrimer and inorganic metal components, are currently being developed as an exciting nanoplatform for several types of molecularly targeted cancer therapy and imaging. Due to its unique chemical structure of dendrimers, [...]
Polymer nanoparticles have been used as carriers to enhance drug delivery. Among them chitosan is the most commonly used carrier, because it promotes long term of incorporated drugs. In the present study,we used DNA vaccine [...]
Journal: TechConnect Briefs
Volume: 2, Nanotechnology 2008: Life Sciences, Medicine & Bio Materials – Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, Volume 2
Published: June 1, 2008
Industry sectors: Advanced Materials & Manufacturing | Medical & Biotech