, Cabral-Teixeira J.
, Chao Y.S.
, Larocca D.
, Maurer J.
, Mercola M.
, Price J.
, Prigozhina N.
, Ruoslahti E.
, Snyder E.
, Tsuda M.
, West M.D.
, Zhang L.
, Advanced Cell Technology, US
Pluripotent stem cells offer great potential for treating diseases where cells are lost to injury or disease processes. The ability to specifically label progenitor cells in populations of differentiating stem cells will provide a powerful [...]
Phage display is a powerful discovery tool with a variety of applications including identification of peptides that specifically recognize and bind to cell-surface targets. Phage particles carrying such peptides have the potential to serve as [...]
We present a novel application of filamentous bacteriophages as targeted drug carrying nanomedicines. The phages are engineered to display target-specificity-conferring peptides or proteins on their coat, and carry a large payload of a cytotoxic drug [...]
Phage peptide libraries proved to be invaluable source of the ligands specifically binding numerous analytes. Diversity and repertoir of the libraries are critical for the successful selection of ligands. In landscape libraries guest peptides are [...]
New generations of targeted diagnostic, therapeutic and imaging nanodevices require robust molecular recognition interfaces, which bind their targets with high specificity and selectivity. These bioselective interfaces can be formed by recombinant filamentous phages or their [...]
A method was developed for the introduction of affinity tags onto bacteriophage heads using a phage display technique. It was shown that T4 bacteriophage carrying a biotin-binding polypeptide (Biotin Carboxyl Carrier Protein, BCCP, from acetyl-CoA [...]
Assembling complex structures comprising multiple, inorganic functional elements represents a significant engineering challenge. We have constructed hybrid nanostructures based on T7 and M13 phage and incorporating a variety of metals and metal oxides. Synthesis of [...]
Cancer chemotherapy is complicated by a lack of selective drug targets. The use of liposomes as vectors for drug delivery has provided a route to selective accumulation of nanoparticles in the tumor interstitium due to [...]
Landscape phage libraries are collections of filamentous phages displaying random foreign peptides on all 4,000 surface domains of the major coat protein. They serve as a rich source of bioselective materials that are used in [...]
Hydroxyapatite [(Ca5(PO4)3OH)2] is a biomineral which is associated with bone proteins to form mineralized extracellular matrix in a mature bone. Using two landscape phage libraries, in which random octa-peptides and nona-peptides are displayed on all [...]
Journal: TechConnect Briefs
Volume: 2, Nanotechnology 2008: Life Sciences, Medicine & Bio Materials – Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, Volume 2
Published: June 1, 2008
Industry sectors: Advanced Materials & Manufacturing | Medical & Biotech