Upconverting nanoparticles for in vitro and in vivo cellular imaging


Keywords: , , ,

Conventional fluorescent labels are of limited in vivo utility because short-wavelength radiation penetrates tissues poorly and excites strong background autofluorescence. Upconversion nanoparticles (UCN) convert low-energy exciting photons to visible emissions, resulting in deep tissue penetration and high detection sensitivity in vivo. Here, we report the synthesis and characterization of fluorescent UCN and demonstrate their use in molecular imaging in vitro and in vivo in small animals.

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Journal: TechConnect Briefs
Volume: 2, Nanotechnology 2008: Life Sciences, Medicine & Bio Materials – Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, Volume 2
Published: June 1, 2008
Pages: 535 - 538
Industry sectors: Advanced Materials & Manufacturing | Medical & Biotech
Topic: Biomaterials
ISBN: 978-1-4200-8504-4