Development of peptide conjugated Superparamagnetic Iron Oxide (SPIO) Nanoparticles for Targeted MR Imaging and Therapy of Pancreatic Cancer

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We have engineered superparamagnetic iron oxide (IO) nanoparticles targeted to urokinase plasminogen receptors (uPAR), which is highly expressed in tumor cells, intratumoral fibroblasts and tumor endothelial cells and can also be internalized by cells. IO [...]