Papers:
Evaluation For The Current Management of Pompe Disease
Pompe disease in an autosomal recessive inherited condition characterised by deficiency of the enzyme acid -glucosidase. This causes accumulation of glycogen in muscles, significantly in the heart. The affect is a progressive muscle dysfunction, leading [...]
Advances in Automated 3D cortex image data acquisition
The study of the 3D architecture of cortex requires the creation of image datasets with sufficient detail in all directions. The detail level required to produce meaningful data requires imaging quality that allows identification of [...]
CNT and Organic FETs Based Two-Way Transducing of the Neurosignals
A superconducting field-effect transistor (SuFET) based neurotransducer (sensor) with carbon nanotubes (CNT) or pickup coil kind of input circuit for the nerve and neuron impulse has been designed. Electronic or ionic currents in conductors or [...]
Quantum dot (Qdot) labeling of gene expression analysis and single molecule imaging in neurons
Jeromin A., Riley Z., Byrnes E., Parry S., Smith S., Dee N., Jones A., Allen Institute for Brain Science, US
The Allen Brain Atlas1 is the first large scale atlas of gene expression in the mouse brain, using chromogenic in situ hybridization (cISH) of over 20,000 genes.Qdots have excellent potential for muliplex imaging of gene [...]
Myelin-mimetic lipid multilayers
The myelin sheath is among nature’s most fascinating nanoscale assemblies. In spite of its critical role in physiology, several questions on the structure-function relationship of myelin and its components remain unanswered. This is chiefly due [...]
Temperature Sensitive Liposomes for Local Drug delivery Using Focused Ultrasound
Local delivery of therapeutic drugs will increase drug concentration at the site of treatment for maximum efficacy, and reduce systemic drug exposure. The encouraging results obtain in first phase of the clinical study of doxorubicin [...]
Low molecular weight heparin-vectorized _-cyclodextrin nanostructures
We set up different synthetic approaches to afford new different nanostructures cyclodextrin – low molecular weigh heparin (LMWH) characterized by covalent bonds (amine or amide) between -cyclodextrin and LMWH in different positions of the heparin [...]
The different biological activity between the colloidal silver nanoparticle and the plasma silver nanoparticle in various cell types
Purpose: The objective of this study was to exam any difference after treatment of nanoparticle in cellular proliferation and gene expression in various cell types. Particularly, it was compared between the colloidal silver nanoparticle and [...]
Magnetically associated carbon nanotubes with mammalian cells: flow cytometry characterization and applications
Cai D., Blair D., Dufort F.J., Gumina M.R., Huang Z., Hong G., Kempa K., Ren Z.F., Chiles T.C., Boston College, US
Magnetic CNT can be driven into cells because it has an embedded Ni nanoparticle in its tip. We show herein that CNT-cell complexes are formed in the presence of a magnetic field. The complexes were [...]
Nanoparticle-enhanced Magnetic Field Induces Apoptosis in Nematode
To investigate molecular consequence of magnetic field to C. elegans, Fe3O4 nanoparticles were incorporated into the culture media of C. elegans and the nematodes were grown under magnetic field for 4 days. For the expermental [...]
Potential anti-inflammatory properties of biologically-synthesized nanoparticles of gold or silver
Vercruysse K.P., Harper S.L., Ivory D.M., Whalen M.M., Saili K.S., Tanguay R.L., Tennessee State University, US
Ionic gold (Au) compounds have been used for many years in the treatment of rheumatoid arthritis (aurotherapy). Despite their long history, the basis for their therapeutic properties has never been established definitively. We have observed [...]
NanoBio-Tools for Selective Activation of Toll-like receptors (TLRs)
Shukoor M.I., Natalio F., Langguth P., Schreiber W., Schröder H.C., Müller W.E.G., Tremel W., Johannes-Gutenberg University, DE
One of the emerging goals of nanotechnology is to functionalize inert materials to impart precise biological functions resulting in biocompatible nano-platforms. The exploration of the interaction between nanostructured materials and living systems is of fundamental [...]
Improved Tissue Distribution, Renal Clearance and Toxicity Profile of Functionalised Carbon Nanotubes
Carbon nanotube (CNT) development for biomedical applications is in the nascent stages, however is thought to lead to novel types of diagnostic, therapeutic and regenerative nanomedicines. The construction of CNT-based delivery systems able to traffick [...]
Multifunctional Polymeric Nanosystems for EGFR Gene Silencing
Multifunctional polymeric nanoparticles with an average size of 200nm could be prepared using the solvent displacement technique. Cetyltriethylammonium bromide (CTAB) surface-modified poly(ethylene oxide)-modified poly(epsilon-caprolactone) (PEO-PCL) nanoparticles encapsulated PTX and siRNA with a loading efficiency > [...]
Carbon Nanopipes dispersions in aqueous solutions and effects on cell viability
The development of carbon nanomaterials for biomedical applications appears highly attractive due to their nanoscale properties although their biological profile is still in doubt. Herewith, we report that the amorphous vs crystalline character of carbon [...]
Novel Resorbable Drug-Carrying Nano-Scaffolds for Treating Bone Diseases at Targeted Sites
Pharmaceutical agents are often required to stimulate new bone formation for the treatment of bone injuries or diseases (such as osteoporosis and osteosarcoma). However, there are several problems associated with current drug delivery methods. First, [...]
Removing Active Species by Fullerenol in vitro and in vivo
Yin J-J., Lao F., Wamer W-G., Zhao Y., Gao X., Wang P-C, Chen C., Liang X-J., National Center for Nanoscience and Technology of China, CN
We previously demonstrated that gadolinium endohedral metallofullerenol ([Gd@C82(OH)22]n nanoparticles) had high inhibitory activity on growth of malignant tumor in vivo by uncertain mechanism(s). The activities of enzymes associated with the metabolism of reactive oxygen species [...]
Non-Condensing Calcium Alginate Microspheres for Macrophage-Selective Gene Delivery and Transfection
The main objective of the study was to design a non-condensing polymer microsphere-based gene delivery system for macrophages. An external gelation technique was used to prepare plasmid DNA-encapsulated calcium alginate microspheres. The microspheres were characterized [...]
The therapeutic effects of silver nanoparticle on the inflammatory disease of the temporomandibular joint
Purpose: The objective of this study was to exam the therapeutic effects of silver nanoparticle on the inflammatory disease of the temporomandibular joint in the animal model. Materials and Method: Mustard oil was injected to [...]
Upconverting nanoparticles for in vitro and in vivo cellular imaging
Conventional fluorescent labels are of limited in vivo utility because short-wavelength radiation penetrates tissues poorly and excites strong background autofluorescence. Upconversion nanoparticles (UCN) convert low-energy exciting photons to visible emissions, resulting in deep tissue penetration [...]
Emerging Trends of Nanotechnology towards Picotechnology: Energy and molecules
In nature, metal oxide particles display their existance at the level of picomolecules in solution state and bioactive states in the body. We put evidence of picomolar behavior of molecules different than nanomolar behavior of [...]
Use of Nanoparticles as Therapy for Respiratory Syncytial Virus Inhibition
Vig K., Boyoglu S., Rangari V., Sun L., Singh A., Singh S.R., Pillai S., Singh A., Singh S.R., Alabama State University, US
Respiratory Syncytial Virus is the leading cause of severe respiratory illnesses such as bronchiolitis and pneumonia in young children. RSV is a paramyxovirus with negative-sense genomic RNA that encodes for eleven proteins, two of which, [...]
Inflammation and Cellular Toxicity Study of PAMAM Dendrimer Nanoparticles in Primary Isolated Human Lung Cells
Khan M.K., Kariapper M.S.T., Kasturirangan V., Lesniak W., Sharma M., Baumann H., Balogh L.P., Translational Research Scientist, US
Poly(amidoamine) (PAMAM) based dendrimers are a class of organic particulate nanomaterials with great promise for improvement in cancer imaging and therapy. In this study, we systematically modify terminal groups of the parent generation 5 primary [...]
In Vitro Toxicity Study of Gold and Tin Composite Nanodevices for use in Imaging and Radiotherapy
Khan M.K., Kariapper M.S.T., Kasturirangan V., Nair B., Lesniak W., Balogh L.P., Roswell Park Cancer Institute, US
Composite nanodevices, with PAMAM dendrimer and inorganic metal components, are currently being developed as an exciting nanoplatform for several types of molecularly targeted cancer therapy and imaging. Due to its unique chemical structure of dendrimers, [...]
Evaluation of Nanoencapsulated DNA Vaccine for RSV
Polymer nanoparticles have been used as carriers to enhance drug delivery. Among them chitosan is the most commonly used carrier, because it promotes long term of incorporated drugs. In the present study,we used DNA vaccine [...]
Journal: TechConnect Briefs
Volume: 2, Nanotechnology 2008: Life Sciences, Medicine & Bio Materials – Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, Volume 2
Published: June 1, 2008
Industry sectors: Advanced Materials & Manufacturing | Medical & Biotech
Topic: Biomaterials
ISBN: 978-1-4200-8504-4