Microfluidics and Lab on Chip – TechConnect Briefs

Inkjet Assisted Micro-Scale Cooling of Electronics

Sharma R.K., Bash C.E., Patel C.D., Hewlett Packard Co. Laboratories, US

Rise in the overall power dissipation of computer systems has posed a severe challenge for cooling microprocessors. Increases in microprocessor power dissipation and the resulting effect on the cost and complexity of thermal management solutions [...]

A Computational Model for the Design of ElectroWetting On Dielectric (EWOD) Systems

Bedekar A.S., Jenkins J.W., Sundaram S., CFD Research Corporation, US

Microfluidics has enabled the development of integrated lab-on-a-chip (LoC) devices for use in a clinical diagnostics, high throughput screening, drug discovery, biodefense and environmental monitoring. Although most microfluidic devices are based on continuous flow of [...]

Dimensioning of a New Micro-Needle for the Dispense of Drugs in Tumors and Cell Clusters

Berthier J., Rivera F., Caillat P., Berger F., CEA-LETI, FR

In medical treatment, there is a constant need to deliver active molecules into targeted cells, but this dispense is often difficult and time consuming. For example, in cancerology, it has been shown that active molecules [...]

Electrostatic Droplet Ejector with Monolithic Fabrication of Nozzle

Lee S-H., Byun D.Y., Ko H.S., Kim Y., Yang J.H., Han S.J., Son S.U., Oh J.T., Konkuk University, KR

This paper presents a novel mechanism of electrostatic micro droplet formation and ejection of fluid. Unlike conventional electrostatic jetting which requires a high operating voltage, we offer a, commercially viable, low operating voltage for droplet-on-demand [...]

The Application of Micro Reactors for Chemical Synthesis: How small is required?

Watts P., University of Hull, UK

Drug discovery is a very time consuming process, with one of the slowest steps being the synthesis and purification of candidates. Several companies have acknowledged that the miniaturisation of chemical reactors offer many advantages of [...]

An Analytical Model for the Prediction of Microdrop Extraction and Splitting in Digital Microfluidics Systems

Berthier J., Raccurt O., Clementz Ph., Jary D., Claustre P., Peponnet C., Fouillet Y., CEA-LETI, FR

In the preceding text submitted to Nanotech 2005, we have demonstrated that surface tension is the dominant force on liquid microdrops in EWOD microsystems and that the problem is mostly topological. Minimization of the surface [...]

Thermal Modulation and Instability of Viscous Microjets

Furlani E.P., Eastman Kodak Company, US

Liquid microjets are inherently unstable and can be broken into droplets by various means including the modulation of pressure, velocity, and/or fluid properties. In this presentation we discuss the controlled breakup of viscous microjets via [...]

Development of Microfluidic Device for Heterogeneous Immunoassay on Polystyrene Platform with Electroosmotic Control

Pribyl M., Snita D., Marek M., Institute of Chemical Technology Prague, CZ

We have developed a microfluidic device for heterogeneous immunoassay on the polystyrene platform. The wire-imprinting method has been chosen for the construction of microchannel structure of the chip. Immunoassay based on the interaction of fluorescently [...]

Fast and Sensitive DNA Hybridization Through Micro- Fluidics

Marafie A.H., Madou M.J., University of California Irvine, US

The research target for DNA hybridization through micro-fluidics is to achieve a fast and very sensitive hybridization reaction by investigating the effect of different pertinent parameters using computational and experimental methods. The mathematical model that [...]

Investigation of Volume of Fluids (VOF) Method and System Models for Design of Microfluidic Ink Delivery Apparatus for Dip Pen Nanolithography (DPN)

Banerjee D., Texas A&M University, US

DPN™ is a versatile technology that leverages Scanning Probe Microscopy for applications in biotechnology, photomask repair, molecular-electronics, nano-electronics and mask-less lithography(1). In earlier studies (2) the DPN process was augmented for biotechnology applications (genomics, proteomics) [...]

Modular Design Approaches for MicroFluidic Systems

Gilde M.J., van den Vlekkert H., Leeuwis H., Prak A., CapiliX BV, NL

The possibilities promised by microfluidic systems have not only interested scientists, but also industries, especially in the areas of the Life Sciences (food, medical, biotech) and fine chemistry (pharma) [2]. Microfluidics is the MEMS-field in [...]

Mechanical Behavior of Micro-Drops in EWOD Systems: drop extraction, division, motion and constraining

Berthier J., Clementz Ph., Jary D., Raccurt O., Claustre P., Peponnet C., Fouillet Y., CEA-LETI, FR

We present a novel contribution to the design of electrowetting microdevices (EWOD) by using an energy minimization approach. Altough the dynamics of motion of microdrops by electrowetting may be rapid, it is shown that, due [...]

The Manufacture and Preliminary Testing of a Novel Bio-MEMS Filtration Chip

Docker P.T., Prince M., Kinnell P.K., Ward M.C.L., Ma X., Birmingham University, UK

In the clinical/microbiological laboratory there are currently several ways of separating specific cells from a fluid suspension. Conventionally cells can be separated based on size, density, electrical charge, light-scattering properties, and antigenic surface properties. Separating [...]

A Novel Microrheometer for Measuring Rheological Properties of Microquantities of Fluids

Lo C.S., Prewett P.D., Ward M.C.L., Docker P.T., University of Birmingham, UK

This paper describes a novel micromachined microrheometer, designed to measure the rheological properties of micro quantities of fluids. Measurements are achieved by monitoring the movement of superparamagnetic microbeads whilst in suspension in fluid when placed [...]

Design, Modelling and Simulation of a PZN-PT Actuated Micropump

Malleo D., Haas C., Kraft M., University of Southampton, Microelectronics Group, UK

We present an optimization methodology for the design of a self-priming piezoelectrically actuated pump made of a borosilicate glass bonded to silicon. New findings in the design optimization of the piezo-actuated membrane are presented: it [...]

Modeling, Analysis and Design of Centrifugal Force Driven Transient Filling Flow into Rectangular Microchannel

Kim D.S., Kwon T.H., Pohang University of Science and Technology, KR

In this paper, we first present successful modeling and analysis results of a centrifugal force driven transient filling flow into a rectangular microchannel. Two types of exact and pseudo-static approximate solutions were derived for the [...]

Multiobjective Evolution Strategies for Optimization of Microfluidic Mixing

Mautner T., Consultant, Technology Development, US

microfluidics, lattice Boltzmann, opimization, biosensor Summary: An investigation has been performed to determine the effect of various surface temperature distributions on the mixing of a binary fluid. Lattice Boltzmann simulations were conducted on a binary [...]

Characteristics of Bacterial Pumps in Microfluidic Systems

Kim M-J, Breuer K.S., Brown University, US

In this paper we show that (i) the flow-deposition of bacteria can successfully create a live bacterial carpet to generate local fluid motion inside a microfabricated system; (ii), that the carpet-activated microfluidic system can be [...]

Valving in Microchannels via Electrodeposition on Solid Electrolytes

Kozicki M.N., Maroufkhani P., Mitkova M., Arizona State University, US

We have recently developed a reliable and inexpensive way to electrically regulate flow through microchannels via a structure that can be made using readily available microfabrication techniques. We use an electrical signal to stimulate silver [...]

Computational Modeling and Simulation of Microfluidic Biochips for Parallel Biomolecular Synthesis

Kan H-C, National Center for High-performance Computing, TW

In this study, a novel microfluidics based biochip has been developed by the aid of analytical modeling and numerical simulation efforts for the purpose of massively parallel oligonucleotude-DNA (oDNA) syntheses. The microfluidic biochip consists of [...]

Compact Model of a Laminar Micro Mixer

Cupelli C., Koltay P., Zengerle R., Santer M., University of Freiburg, DE

In this paper we discuss a novel approach towards a system-level description for microreactors. In particular, a compact model for laminar micromixers for fluids with different viscosities is presented. We show how the well known [...]

Sample Concentration by Asymmetry EOF flow in Micro/Nano Channels with O2/H2O Plasma Treated Channel Surfaces

Wu R-Q, Tseng F-G, Yang C-S, Cheing C-C, National Tsing Hua University, TW

In this study, we propose a new technique to concentrate sample effectively, which employs different surface treatment on the top and bottom of micro/nano channels. This treatment carries out different zeta-potentials on the opposite walls [...]

Fabrication of Microfluidic Cells with Liquid Core Waveguide and 1,1’-Oxalydiimidazole Chemiluminescence Detection

Lee J-H., Tartaglia A., Schlautman M.A., Carraway E.R., Clemson University, US

We have developed simple and inexpensive microfluidic cells (inner diameter: 100 _m) based on the principles of liquid core waveguide (LCW) and rapid 1, 1’-oxalyldiimidazole derivative chemiluminescence (ODI-CL) reactions. The microfluidic cells devised in this [...]

Simulation Toolkit for Micro-Fluidic Pumps using Lumped Models

Litterst C., Streule W., Zengerle R., Koltay P., IMTEK, University of Freiburg, DE

Simulation of micro pumps is complicated by the interaction of various physical domains. The fluid structure interaction (FSI) essentially determines the dynamics of micro pumps and therefore has to be taken into account. Mesh based [...]

Fast mixing using the Shear Superposition Micromixer

Bottausci F., Cardonne C., Mezic I., Meinhart C., university of california, santa barbara, US

We present new experimental results showing high efficiency mixing procedures for an active shear superposition micromixer (SSM). This micromixer consists of a main mixing channel where unmixed fluids are perturbed by jet flows emanating from [...]

Evolution of Streaming Potential in a Finite Length Microchannel

Mansouri A., Bhattacharjee S., Kwok D.Y., Kostiuk L.W., University of Alberta, CA

Pressure-driven-flow in a microchannel with charged solid surfaces induces streaming current and streaming potential. Review of the literature, reveals that most of the studies on the microchannels are either for steady state solution or infinite [...]

Nanofluidic Size Exclusion Chromatograph for In Site Macromolecular analyses

Choi D., Grunthaner F., Feldman S., Svehla D., Jet Propulsion Laboratory/California Institute of Technology, US

We are developing a nanofluidic size exclusion chromatograph (nano-SEC) system that can be incorporated into miniature lab-on-a-chip devices which will provide detailed information on the geochemical and biological history of soil, ice, and water samples [...]

A Droplet Microarray for Homogeneous Enzymatic Assay

Balakirev M., Mugherli L., Chatelain F., CEA-Grenoble, FR

This work describes a droplet microarray for monitoring of enzymatic activity on a glass slide. These array are composed of features defined and separated by differential surface tension (surface tension array). A photolithographic method was [...]

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