This paper reviews and compares different strategies for designing and building up microfluidic systems, with a special emphasis on the system aspect as opposed to single components capable of performing only special operations. An overwhelming [...]
We present a novel approach towards the needs of a versatile microfluidic chip-based microfluidic system with unique properties and functionality. Like for microarrays and in contrast to many existing microfluidic technologies, the fluid handling is [...]
The material distribution method in topology optimization was developed in the late 1980ies for stiffness design of mechanical structures, and only recently the first steps have been taken towards implementing the method in fluidics. Topology [...]
This paper presents a composable system simulation framework using an analog hardware description language implementing behavioral models for electrokinetic micromixers that are capable of accurately capturing the effects of mixer topology/geometry, flow ratio and material [...]
Lab-on-a-chip technologies combine a sequence of chemical and/or biological analyses on a miniaturized platform to perform an analytical task or series of tasks. Lab-on-a-chip applications include chemical/biological agent detection, DNA sequencing/analysis, and drug discovery, to [...]
Using molecular dynamics simulations, we identified in previous work a new adsorption phenomenon in which, for poorly wetting fluids, a suspended particle, initially moving along the center of the nanochannel, is adsorbed onto the tube [...]
Electrokinetic transport is widely encountered in many nanofluidic systems, and understanding its scaling as a function of various operating conditions, e.g., bulk concentration, is important for establishing design rules and for exploring the design space. [...]
The rapid convergence of nanotechnology and biotechnology has generated a need for design tools that can incorporate sufficiently detailed models of the nanoscale molecular phenomena with overarching transport and related effects in microfluidic devices. Currently, [...]
We use fluorescence video microscopy and single particle tracking to elucidate some of the fundamental mechanisms involved in intracellular trafficking of non-viral gene vectors. Transport of polymer-DNA complex, which are internalized via endocytosis, is almost [...]
We demonstrate a hierarchical multiscale methodology to solve ion transport in nanoscale channels and show that the partial charges from quantum calculations significantly alter transport properties and I-V plots for electrolytes in confined geometries. Effects [...]
Microfabrication technology has enabled the application of electrokinetics as a method of performing chemical analyses and achieving liquid pumping in electronically-controlled microchip systems with no moving parts. This talk reviews progress at Stanford in the [...]
, Kawabata T.
, Kazakova I.
, Simeonov A.
, Park C.
, Kechagia P.
, Spaid M.
, Watanabe M.
, Satomura S.
, Wako Pure Chemical Industries Ltd., US
The promise of microfluidic immunoassays in microchips has been the miniaturization, integration and automation of rapid immunoassays. The typical microfluidic assays have used fluorescent dye labeled antibodies in direct binding assays or labeled antigens in [...]
This paper presents an investigation on hydrodynamic/electrokinetic focusing and switching, which are crucial for microfluidic applications. The hydrodynamic/electrokinetic focusing phenomenon is first theoretically modeled by employing a potential flow theory, and this simple theoretical model [...]
An injector modeling methodology based on neural networks is presented. The new aspects of this approach are (1) the full description of the dynamic injector behavior and (2) the applicability of the approach to a [...]
Buoyancy driven fluid motion, however, can also occur in closed loop geometries in response to either vertically or horizontally imposed temperature gradients. These systems offer the exciting possibility of generating unidirectional laminar flows along a [...]
A CD-based flow-through approach for DNA immobilization on gold surfaces was proposed and validated using 25-mer thiol-derivatized nucleotides (T-SH) labeled with fluorescent (Cy3) dye. Amino-derivatized ssDNA (T-amino) of the same sequence was used as a [...]
Testing the deluge of hypotheses flowing from genomics and systems biology demands accurate and cost-effective gene and genome synthesis. Here we describe a microchip-based technology for multiplex gene synthesis. Pools of thousands of "construction" oligonucleotides [...]
Microfluidic technology is a key component in the development of microfabricated lab-on- a-chip systems for use in bioanalytical and biosensing applications. These devices continue to be developed to perform a variety of DNA analysis assays, [...]
, Takatsuki H.
, Hornak L.A.
, Brown K.
, Chilakamarri R.
, Timperman A.
, Lenke J.
, Gannett P.
, Kohama K.
, West Virginia University, US
Control of biomolecular transport is essential to the advancement of nanokinematic systems whether for molecular cargo delivery in sensing or assembly processes, or as a means to interface micro-electro-mechanical systems with the nanoscale regime. Actin-myosin [...]
There is a growing need for compact and reliable advanced microfluidic devices and/or adapters for conventional capillary electrophoresis (CE) that can provide an improved resolving power of analytes. It is demonstrated that separation of analytes [...]
Journal: TechConnect Briefs
Volume: 1, Technical Proceedings of the 2005 NSTI Nanotechnology Conference and Trade Show, Volume 1
Published: May 8, 2005
Industry sector: Sensors, MEMS, Electronics
Topic: Micro & Bio Fluidics, Lab-on-Chip