Berthier J. – TechConnect Briefs

Two-phase spontaneous capillary microflows and the transport of capillary wagons

Berthier E., Berthier J., Brakke K., Gosselin D., Lee Jing, Navarro F., Theberge A., CEA-LETI, FR

The use of capillarity to move fluids at the microscale has been soaring lately due to new applications in medicine, biology, biotechnology, energy, thermic and space. Especially of interest are open capillary channels. These channels [...]

On the use of Zisman’s function for the determination of the velocity of spontaneous capillary microflows

Berthier E., Berthier J., Gosselin D., Lee Jing, Navarro F., Theberge A., CEA-LETI, FR

Capillary-based microfluidic systems are increasingly used in the fields of biotechnology, medicine, thermics, energy and space. In such systems the energy source responsible for the flow is the surface energy of the walls. Extending the [...]

Low-cost screen printed and embossed LAMP micro-reactors

Baque M., Belgacem M.N., Berthier J., Bourdat A.G., Chaussy D., Gosselin D., Gougis M., Maffini-Alvaro V., Mailley P., Navarro F., Révol-Cavalier F., Vignoud S., CEA-Grenoble, FR

Introduction: Diagnostic is probably the most important step in the fight against infectious diseases and epidemics. While it is necessary to give a treatment to diseased people, it is just as important to give the [...]

Deterministic Lateral Displacement (DLD): Finite element modeling and experimental validation for particle trajectory and separation

Agache V., Berthier J., Gosselin D., Icard B., Navarro F., Pariset E., Pudda C., Révol-Cavalier F., CEA-LETI, FR

In biotechnology and biology, deterministic lateral displacement (DLD) arrays are used to separate particles based on their size, such as cells, bacteria, parasites and exosomes. DLD is very promising for sample preparation purposes as it [...]

On the use of polymeric additives to promote plasma separation from whole blood in open microchannels

Berthier J., Cubizolles M., Laurent P., Lee E., Navarro F., CEA, FR

Polymers additives in whole blood are known to modify blood physical properties. For example, Dextran molecules usually accelerate the aggregation of re-suspended RBCs in Ringer solutions. In this work, we first investigate the effect of [...]

Study of low Rayleigh heaters for biomedical diagnostic tools

Belgacem N., Berthier J., Chaussy D., Delapierre G., Delon A., Gosselin D., CEA, FR

Microfluidic is a very promising technology to improve biomedical devices and to provide diagnostic tools for the developing world. The World Health Organization has introduced a list of requirements that an ideal diagnostic tool for [...]

Capillary flow of whole blood in microsystems: non-Newtonian blood behavior and substrate reagent-coating effect

Berthier J., Cosnier M.L., Cubizolles M., Gosselin D., Huet M., Pouteau P., Sabatte G., CEA-Leti (University Grenoble Alpes), FR

Introduction: The use of whole blood is a preferred solution for portable diagnostic and monitoring systems. We analyze here two particularities of microsystems for blood analysis: the blood non-Newtonian behavior, and the capillary flow in [...]

Combined effects of pump and capillary pressures for the filling of microchannel networks: the difficulty of synchronization

Berthier J., Diakite M.L., CEA-Leti (University Grenoble Alpes), FR

In this work, we first propose a model for the filling of a capillary tube driven by a pressure pump. It is shown that the filling time depends not only on the pump pressure but [...]

On the dynamic contact angle in spontaneous capillary flow

Berthier J., Delapierre G., Gosselin D., CEA-LETI, FR

Capillary actuation of fluids is an interesting solution when the gravitational forces are small: this is the case in space , or in microfluidic systems where gravity is negligible. The onset of spontaneous capillary flow [...]

Recent advances in capillary microflows for point-of-care and home-care devices

Berthier J., Cubizolles M., Delapierre G., Gosselin D., Huet M., CEA/LETI/MINATEC, FR

Biotechnology has been recently seeing fundamental evolutions: first, a clear shift towards biological applications; second a trend towards the design and fabrication of portable devices; third the choice of inexpensive materials such as plastic or [...]