In this study, we propose a new technique to concentrate sample effectively, which employs different surface treatment on the top and bottom of micro/nano channels. This treatment carries out different zeta-potentials on the opposite walls of micro/nano channels for generating asymmetry EOF flow to concentrate samples into one side of the channel. By employing this technique combined with nanochannel, the sample concentration and diffusion length for the sample to the electrochemistry detection site is greatly reduced, and near one order of magnitude signal enhancement has been achieved in this study.
Journal: TechConnect Briefs
Volume: 1, Technical Proceedings of the 2005 NSTI Nanotechnology Conference and Trade Show, Volume 1
Published: May 8, 2005
Pages: 728 - 731
Industry sectors: Medical & Biotech | Sensors, MEMS, Electronics
Topic: Micro & Bio Fluidics, Lab-on-Chip