Materials for Drug & Gene Delivery

Precise Phage-navigating Metastatic Breast Cancer-targeted Paclitaxel-Micell Nanomedicines

Petrenko V.A., Torchilin V.P., Auburn University, US

Breast cancer is one of the most common cancers in the USA. Despite the increase of relative survival rate of women with breast cancer for the last decades, it is still low (~26%, 5 years) [...]

Bedaquiline loaded lipid nanoparticles: a promising candidate for TB treatment

Jary D., Hibbitts A., Lozano-Fernandez T., Pérez D., Lucia A., Ainsa J.A., Codony D., Freire C., Redinger N., Schaible U., Coya Raboso J.M., Tailleux L., Navarro F., CEA-LETI, FR

Increase in antibiotic resistance is a global concern worldwide[1], with 480,000 new cases of multi-drug resistant tuberculosis (MDR-TB) diagnosed each year. Therefore, the goals for the Nanotherapeutics for Antibiotic Resistant Emmerging Bacterial pathogens (NAREB) research [...]

Modeling of polypeptide- and polymer-conjugated nanoparticles for drug delivery application

Lee H.K., Dankook University, KR

Nanoparticles such as liposomes, dendrimers, and carbon nanotubes have many potential biomedical applications as antitumor therapeutics and drug delivery. These applications require the interaction of those with cell membranes, thus interactions of nanoparticles, polymers, and [...]

Impact of Docetaxel conjugated Nanodiamonds on Gene expression of Prostate Cancer (PC3) Cells

Cedeño Ortiz J.D., Joshi S., Singh S.R., Vig K., Alabama State University, US

Prostate cancer (PC) is the second leading cause of adult male death in the United States. This type of cancer is a disease where the prostate gland cells start to grow without control, changing in [...]

Nanostructured Lipid Carriers to Deliver HIV p24 Antigen and CpG Immunostimulant in Mice and Non-Human Primates Immunogenicity Studies

Bayon E., Morlieras J., Gosse L., Gonon A., Bosquet N., Le Grand R., Marche P.N., Navarro F.P., CEA-LETI, FR

Fighting HIV pandemic is one of today’s major health priorities and vaccination remains the most challenging issue against HIV propagation. Until now, the best vaccine candidate showed only 30% protection in RV144 clinical trial [1]. [...]

Exacerbation of amyloid beta peptide and Tau protein in the cerebrospinal fluid following Traumatic Brain Injury at Hot Environment. Neuroproetction by TiO2 nanowired delivery of cerebrolysin with tau antibodies

Sharma A., Sharma H.S., Lafuente J.V., Muresanua D.F., Castellani R.J., Smith M.A., Nozari A., Patnaik R., Tian Z.R., Ozkizilcik A., Mössler H., Sharma A., Sharma H.S., Uppsala University, Uppsala, SE

Military personnel are often exposed to high environmental temperature in desert areas during combat operations. Since traumatic brain injury (TBI) is quite common in combat operation, a possibility exists that hot environment (HE) could affect [...]

Co-administration of TiO2 nanowired cerebrolysin and alpha melanocyte stimulating hormone has superior neuroprotective effects on brain pathology following concussive head injury after sleep deprivation

Sharma A., Sharma H.S., Lafuente J.V., Muresanua D.F., Nozari A., Patnaik R., Tian Z.R., Ozkizilcik A., Mössler H., Sharma A., Sharma H.S., Uppsala University, Uppsala, SE

Sleep deprivation (SD) is common in military personnel engaged in combat operations. Our previous reports show that 12 h SD alone induces brain pathology and continued until 72 h in a progressive manner. However, these [...]

Intraspinal administration of TiO2 nanowired cerebrolysin with mesenchymal stem cells has superior neuroprotective effects on cord pathology and functional outcome following a focal spinal cord trauma

Feng L., Sharma A., Sharma H.S., Niu F., Huang H., Lafuenta J.V., Muresanu D.F., Ozkizilcik A., Tian Z.R., Sharma A., Sharma H.S., Bethune International Peace Hospital, CN

Military personnel are often victims of spinal cord injury (SCI) for which there is no suitable treatment available. Thus, exploring new therapeutic avenues using select combination of novel neuroprotective agents is the need of the [...]

TiO2 nanowired delivery of cerebrolysin induces superior neuroprotection following exacerbation of blast brain injury pathophysiology in diabetes

Muresanu D.F., Sharma A., Sharma H.S., Lafuente J.V., Nozari A., Patnaik R., Nozari A., Ozkizilcik A., Tian Z.R., Mössler H., Sharma A., Sharma H.S., University of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca, Romania, RO

Blast brain injury (bBI), a combination of pressure, rotation, penetration of sharp objects and chemical exposure is prevalent in military personnel during combat operations causing laceration, perforation and tissue loss in the brain. Since combat [...]

Nanodelivery of Chinese traditional medicine extract of Gingko Biloba (EGb-761) induces superior neuroprotection following traumatic brain injury in heat stroke

Sharma A., Sharma H.S., Muresanu D.F., Lafuente J.V., Zhang Z-q, Li C., Patnaik R., Tian Z.R., Ozikzilcik A., Sharma A., Sharma H.S., Uppsala University, Uppsala, SE

Military personnel are often exposed to high summer heat resulting in heat stroke (HS) and related illnesses. HS often results in serious mental and physical consequences due to breakdown of the blood-brain barrier (BBB) to [...]

Functional Polylactide-based Systems for Delivery of Cancer Therapeutics

Cheng C., Sun H., Yu Y., Chen C-K, Cheng C., Zou J., University at Buffalo, the State University of New York, US

As an important class of biodegradable polymers, polylactides (PLAs) have been approved by FDA for clinical applications. However, conventional PLAs are lack of functionalities, and this significantly limits their applications. Therefore, in recent years we [...]

Zwitterionic Polymer Surfactants for Drug Delivery

Cao Z., Wayne State University, US

Zwitterionic polymers have found a wide range of applications based on excellent non-fouling properties. It has been demonstrated that their use as surface coatings can effectively resist binding from proteins, cells, and full blood. Nanoparticles [...]

Hybrid Programmable Peptide Crosslinkers as Enzyme-Regulated Drug Delivery Vehicles

Rouge J.L., University of Connecticut, US

Biology has evolved the quintessential nucleic acid delivery vehicle, the virus, using proteins built from self-assembled peptide subunits. These viral protein coats are then degraded by specific enzymes, depending on their location, releasing their contents [...]

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