Intraspinal administration of TiO2 nanowired cerebrolysin with mesenchymal stem cells has superior neuroprotective effects on cord pathology and functional outcome following a focal spinal cord trauma

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Military personnel are often victims of spinal cord injury (SCI) for which there is no suitable treatment available. Thus, exploring new therapeutic avenues using select combination of novel neuroprotective agents is the need of the [...]

TiO2 Nanowired Cerebrolysin enhances neuroprotective effects of mesenchymal stem cells following concussive head injury at hot environments

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Concussive head injury (CHI) could lead to either instant death or lifetime disabilities. Our soldiers are highly vulnerable to CHI during combat operations. Thus, to treat these soldiers effectively novel strategies using combination therapy is [...]

Mn nanoparticles exacerbates closed head injury induced blood-brain barrier disruption, brain pathology, and sensory motor dysfunctions. Neuroproetction by Nanowired delivery of 5-HT2 receptor antagonists Ketanserin and Ritanserin

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This innovation deals with adverse effects of Mn nanoparticles on brain pathology in concussive head injury. Also Mn nanoparticles treatment alters therapeutic modalities. The novel data presented in the abstract show that Mn exposure to [...]

TiO2 nanowired delivery of a Chinese traditional medicine DL-3-n-butylphthalide (DL-NBP) induces profound neuroprotection in concussive head injury

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To develop suitable therapeutic strategies for concussive brain injury (CHI), we have explored the role of a Chinese traditional medicine DL-3-n-butylphthalide (DL-NBP) in a rat model. We delivered this compound alone and also using Titanium [...]