Medical & Biotech – Page 87 – TechConnect Briefs

Magnetic Nanotag-based Immunoassay for Multiplex Mycotoxin Detection

Mak A.C., Osterfeld S., Yu H., Wang S., Davis R.W., Jejelowo O.A., Pourmand N., Stanford University, US

Rapid, sensitive and multiplexed measurement is vital in molecular diagnostics such as cancer diagnosis and pathogens detection. While highly specific and sensitive, traditional immunochemical assays such as enzyme-linked immunosorbent assays (ELISAs) often require expensive read-out [...]

Diamond-based Biosensors with an Impedimetric and Label-free Read-out

Vermeeren V., Bijnens N., Grieten L., Wenmackers S., Vanden Bon N., Haenen K., Wagner P., Michiels L., Hasselt University, BE

Healthcare and diagnostics are moving towards molecular medicine. Hence, a lot of research is being performed on biosensors. However, rarely one has reached the commercialization phase because of the expensive infrastructure required for signal read-out. [...]

Nanoparticle-coated nanosprings for diagnostic applications using SERS based detection

Sai V.V.R., University of Idaho, US

Significant enhancements in the SERS signals may be obtained with elongated arrangement of silver or gold nanoparticles. Silica nanosprings (NS) with high surface to volume ratio are promising candidate to yield such sensor materials. In [...]

Nanopore/electrode structures for single molecule biosensing

Albrecht T., Imperial College London, UK

In this contibution I will present some of our work on solid-state nanopores, the fabrication of nanopore/electrode structures and how these can be used for single-molecule biosensing applications (DNA, proteins etc.). Specifically, I will introduce [...]

Label-Free, Electrical Detection of the SARS Virus N-Protein with Nanowire Biosensors Utilizing Antibody Mimics as Capture Probes

Chang H.K., Ishikawa F., Chiang P.C., Zhou C., University of Southern California, US

In this report, we introduce evolved AMPs as a new class of capture agents for nanowire/nanotube biosensors, and demonstrate selective detection of a protein related to severe acute respiratory syndrome (SARS), using devices based on [...]

Towards an asynchronous magnetic bead rotation method for immunological assays

Hecht A., Kinnunen P., McNaughton B., Kopelman R., University of Michigan, US

Much attention has been focused on using magnetic particles for biodetection applications on chip. Most of these applications involve using the magnetic particles either for translational motion in a magnetic field, or as labels for [...]

SiCN nanomechanical resonators for array-based biosensor applications

Guthy C., Singh A., Tanha J., Evoy S., University of Alberta, CA

Rapid, sensitive and inexpensive analysis of biological molecules is of great importance to many biomedical applications, such as disease detection and monitoring, drug discovery, detection of pathogens, etc. Mechanical resonators have been demonstrated as highly [...]

Label-free, Fluorescenece Detection of DNA Nanoparticle Scaffolds

Kell A.J., Tan S., Charlebois I., Boissinot M., Simard B., National Research Council, CA

We have developed a nanoparticle-based DNA biosensor that can detect unlabelled ssDNA with good sensitivity (picomolar concentrations). The biosensor makes use of the optical changes of a cationic polymer interacting with ssDNA versus that of [...]

Bio Sensors, Diagnostics & Imaging

Surface Constructions of Nano-Micro Structured CaP Biomaterials and Their Biocompatibility

Lin C.J., Wang H., Hu R., Lai Y.K., Geng Z.W., Xiamen University, CN

In this work, we concentrated our attention to develop various methods for surface construction of of calcium phosphate (CaP) and their composite coatings, including octacalcium phosphate (OCP), hydroxyapatite (HAp), micropatterned titanium surface by using electrochemical [...]