Papers:
A Combined DSMC/Meshless Technique for Multiscale Analysis of Microfluidic Filters
A multiscale method that couples a meshless Stokes solver and a DSMC simulator is reported. The method is based on overlapped Schwarz alternating method with Dirichlet-Dirichlet type boundary conditions for domain decomposition and meshless interpolation
Reconfigurable Microfluidic System Architecture Based on Two-Dimensional Electrowetting Arrays
We present an architectural design and optimization methodology for performing biochemical reactions using two-dimensional electrowetting arrays. We define a set of basic microfluidic operations and leverage electronic design automation principles for system partitioning, resource allocation, [...]
Surface Tension Induced Instability of Viscous Liquid Jets
Viscous liquid jets are inherently unstable, and drop formation can be induced by various means including surface tension modulation. Furthermore, surface tension is temperature dependent, and can be modulated by locally heating the surface of [...]
Electroosmotic Microfluidic Flows with Random Zeta Potential
Average electroosmotic ows in the presence of axially-varying zeta potentials are shown to be plug-like, with variances which depend on radial position across the capillary. Consequences for the dispersion of samples are examined theoretically and [...]
Efficient Numerical Methods for the Simulation of Flow Reactors
We describe recent developments in the design of numerical methods for the simulation of heat transport and chemical processes in ow reactors. For viscous ow in the low-Mach-number regime, we use a stable finite element [...]
Mixed-Dimensionality, Multi-Physics Simulation Tools for Design Analysis of Microfluidic Devices and Integrated Systems
Computational design of microfluidic devices and integrated microsystems involves several strongly coupled physical disciplines, including fluid mechanics, heat transfer, stress/deformation dynam-ics, electrokinetics, biochemistry and others. CFDRC is dev
Analysis of Sample Transport in Capillary Electrophoresis Microchip Using Full-Scale Numerical Analysis
An implicit finite-volume numerical scheme has been developed to solve the three-dimensional transport equations along with fully-coupled ionization equilibria in acid/base systems. The scheme solves conservation equations for mass and momentum while satisfying the electroneutrality [...]
Inverted Method for Simulation of Electrokinetic Transport in Microchannel Devices
An inverted method of solution is used to numerically solve the equations governing electrokinetic fluid flow and species transport in microscale turns, junctions and curved channels. Rather than solving for the electric potential and fluid [...]
Electrodynamic Transport, Electroporation and Lysis of Cells in Pharmacological and Bioanalytical Microsystems
Biological information is stored in cells and is the prime object of interest of pharmacological, biomedical, and bioanalytical professionals. Whatever the interest: elcectroporative drug delivery and pharmacodynamics, in vivo PCR, infection pathology, DN
Modeling of Blood Flow in Simple Microchannels
Optimal design of medical micro-assay systems will require computational modeling capabilities. Most existing models are based on macroscale experiments with smallest length dimensions comparable to that of a capillary due to the fact that the [...]
Simulation of Droplet Formation in Micromixers
Droplet formation in micromixers developed by the Institute of Microtechnology Mainz (IMM) is investigated by methods of computational fluid dynamics (CFD). The CFD results are compared to experimental data obtained with transparent micromixers made from [...]
Application of the Direct Simulation Monte Carlo Method to Modeling of Microfluidics
For mathematical modeling of microfluidics it is necessary to calculate a rarefied gas flow through micropumps, microvalves and other elements with high accuracy. Since the size of microfluidics is close to the molecular mean free [...]
A Mathematical Model of a Biosensor
Botkin N.D., Schlensog M., Tewes M., Turova V.L., Center of Advanced European Studies and Research, DE
A mathematical model of a biosensor is considered. The biosensor is supposed to be used for the measurement of small amounts of certain substances in liquids. The device works as follows: acoustic shear waves are [...]
Computational Design Analysis for In-Plane Microfluidic Valves
Simulations of fluid flow across in-plane microvalves were performed using an advanced multi-physics commercial software system and compared with experimental data. Model validation required careful consideration of leakage pathways left by fabrication artifacts. Following model [...]
A Fluid Dynamics Model for a Plasma Ion Acceleration System
We present preliminary results of some simulations for a plasma ion acceleration system, which we plan to construct. This system tires to model the complex interactions between the multiple species of ions (about 5) used [...]
Three-Dimensional Single Step Flow Sheathing in Micro Cell Sorters
Goranovic G., Perch-Nielsen I., Larsen U.D., Wolff A., Kutter J., Telleman P., Bio/Chemical MicroSystems, DK
We present a novel microstructure that enables 3 dimensional hydrodynamic focusing of cells in a pressure driven micro cell sorter. This so-called "chimney" structure for single step coaxial sheathing was designed and optimized through simulation, [...]
A Stochastic Projection Method for Microchannel Flow
The construction and implementaion of a stochastic flow solver is described. The solver combines a spectral stochastic uncertainty representation scheme with a finite difference projection method for flow simulation. The uncertainty quantification scheme is based [...]
Use of Numerical Methods for Modeling and Simulating Capillary Driven Flows in Microchannels
Today, medical test strips are used for rapid diagnostics and the quick and easy determination of biomedically relevant parameters, such as the content of glucose of the blood. For the transport of the test uid [...]
Insects Separate Diffusing Particles in Parallel
The circulation of insects and other invertebrates transfers heat, mass, and momentum within micro-fluids through phase interfaces of complex geometry at size ranges important for developing compact energy and chemical systems. Pump size and vascular [...]
Microflows with Moving Boundaries: Experiment and Simulation
Surface forces and capillary effects can play a dominant role in fluidic microsystems. Therefore it is crucial for simulations to use accurate numerical approaches [1]. Furthermore experimental data gained from such surface dominated systems can [...]
Optimization of a MEMS Based Micro Capillary Pumped Loop for Chip-Level Temperature Control
Recent results in the microfluidics group at the Berkeley Sensor and Actuator Center and the Air Force Research Laboratory have shown that a micro-capillary pumped loop (micro-CPL) can move extreme amounts of heat (< 200 [...]
Simulation of Flow in Structurally Programmable Microfluidic Channels
This paper describes the simulation of liquid filling in a structurally-programmable microfluidic delivery system being developed as part of a disposable biochip for clinical diagnostics. Flow control in the system is achieved by using passive [...]
Atomistic Simulation of Electro-Osmosis in a Nanometer-Scale Channel
An atomistic simulation of an electro-osmostic flow in a 50 ° A wide channel is performed to examine models for such flows and study its physical details. The working fluid considered is a 1.1M mean [...]
Journal: TechConnect Briefs
Volume: 1, Technical Proceedings of the 2001 International Conference on Modeling and Simulation of Microsystems
Published: March 19, 2001
Industry sector: Sensors, MEMS, Electronics
Topic: Micro & Bio Fluidics, Lab-on-Chip
ISBN: 0-9708275-0-4