Makhijani V.B. – TechConnect Briefs

Coupling between Nanoscale and Microscale Modeling for MicroFluidic Devices

Jenkins J.W., Sundaram S., Makhijani V.B., CFD Research Corporation, US

Evaluation of microfluidic device and sensor designs using continuum modeling is a valuable method, but becomes more complex if nanoscale or molecular level physics must be included in the model. Recently, we have undertaken an [...]

Biochemical Binding in Microspheres-Based-Imunoassays

Prabhakarpandian B., Shah K.B., Sundaram S., Makhijani V.B., CFD Research Corporation, US

Microspheres (referred commonly as beads) are being extensively used in biochemical assays as supports for proteins, DNA, etc. We have successfully developed |omputational models for simulating sample detection using flowing beads. The model fully integrates [...]

Numerical and Analytical Studies of AC Electric Field in Dielectrophoretic Electrode Arrays

Feng J.J., Krishnamoorthy S., Chen Z.J., Makhijani V.B., CFD Research Corporation, US

Manipulation of micro-sized particles and biological cells using dielectrophoresis (DEP) is an emerging technique in MEMS and nano technology[3]. This paper presents an exact solution of dielectrophoretic motion of a polarized particle in the vicinity [...]

Biochemical Binding in Microspheres-Based-Imunoassays

Prabhakarpandian B., Shah K.B., Sundaram S., Makhijani V.B., CFD Research Corporation, US

Microspheres (referred commonly as beads) are being extensively used in biochemical assays as supports for proteins, DNA, etc. We have successfully developed computational models for simulating sample detection using flowing beads. The model fully integrates [...]

Analysis of Physico-Chemical Processes in an Amperometric Oxygen Biosensor

Krishnamoorthy S., Feng J.J., Makhijani V.B., Gao C., Choi J.W., Ahn C., CFD Research Corporation, US

Amperometric techniques are commonly used in lab-on-a-chip systems to sense various blood gas analytes such as H+, CO2, O2, etc. In the present study, a microchip-based amperometric biosensor, being developed as a part of plastic-based [...]

Numerical and Analytical Studies of AC Electric Field in Dielectrophoretic Electrode Arrays

Feng J.J., Krishnamoorthy S., Chen Z.J., Makhijani V.B., CFD Research Corporation, US

Manipulation of micro-sized particles and biological cells using dielectrophoresis (DEP) is an emerging technique in MEMS and nano technology[3]. This paper presents an exact solution of dielectrophoretic motion of a polarized particle in the vicinity [...]

Simulation of Flow in Structurally Programmable Microfluidic Channels

Makhijani V.B., Reich A.J., Puntambekar A., Hong C., Ahn C., CFD Research Corporation, US

This paper describes the simulation of liquid filling in a structurally-programmable microfluidic delivery system being developed as part of a disposable biochip for clinical diagnostics. Flow control in the system is achieved by using passive [...]

Computational Design Analysis for In-Plane Microfluidic Valves

Dickey C.K., Makhijani V.B., Deshmukh A., Liepmann D., CFD Research Corporation, US

Simulations of fluid flow across in-plane microvalves were performed using an advanced multi-physics commercial software system and compared with experimental data. Model validation required careful consideration of leakage pathways left by fabrication artifacts. Following model [...]

Analysis of Sample Transport in Capillary Electrophoresis Microchip Using Full-Scale Numerical Analysis

Krishnamoorthy S., Feng J.J., Makhijani V.B., CFD Research Corporation, US

An implicit finite-volume numerical scheme has been developed to solve the three-dimensional transport equations along with fully-coupled ionization equilibria in acid/base systems. The scheme solves conservation equations for mass and momentum while satisfying the electroneutrality [...]

Mixed-Dimensionality, Multi-Physics Simulation Tools for Design Analysis of Microfluidic Devices and Integrated Systems

Przekwas A.J., Makhijani V.B., CFD Research Corporation, US

Computational design of microfluidic devices and integrated microsystems involves several strongly coupled physical disciplines, including fluid mechanics, heat transfer, stress/deformation dynam-ics, electrokinetics, biochemistry and others. CFDRC is dev